公开(公告)号：US11065352B2

公开(公告)日：2021-07-20

申请号：US15851199

申请日：2017-12-21

申请人： Abbott Laboratories

发明人： Patrick Fritchie ,  Pathik Soni ,  Lei Qiao ,  Dustin House ,  Lyle Yarnell ,  Edna Prieto-Ballengee ,  Cathy Forsythe ,  Michael Shawn Murphy ,  Andrew Fischer ,  Akanksha Sharma ,  Joseph Esposito ,  Matt Effinger ,  Michael Futer

IPC分类号： A61L2/04 ,  H05B6/06 ,  H05B6/40 ,  A61L2/24 ,  H05B6/10 ,  H05B6/14

摘要： Inductive heating systems and method of controlling the same to reduce biological carryover are disclosed herein. An example system includes an induction heater including a tank circuit. The example system includes a controller to drive the tank circuit to selectively oscillate at a resonant frequency for the tank circuit to inductively heat a work piece disposed proximate to the tank circuit.

公开(公告)号：US20190351411A1

公开(公告)日：2019-11-21

申请号：US16531253

申请日：2019-08-05

申请人： Abbott Laboratories

发明人： Andrew Fischer

IPC分类号： B01L3/00

摘要： Example methods, apparatus, systems for diluting samples are disclosed. An example method includes depositing a first fluid droplet on a first electrode of a plurality of electrodes. The first electrode has a first area. The first fluid droplet has a first volume associated with the first area. The example method includes depositing a second fluid droplet on a second electrode of the plurality of electrodes. The second electrode has a second area. The second fluid droplet has a second volume associated with the second area. The second volume is different than the first volume. The example method includes forming a combined droplet by selectively activating at least one of the first electrode or the second electrode to cause one of the first fluid droplet or the second fluid droplet to merge with the other of the first fluid droplet or the second fluid droplet.

公开(公告)号：US20180193498A1

公开(公告)日：2018-07-12

申请号：US15851199

申请日：2017-12-21

申请人： Abbott Laboratories

发明人： Patrick Fritchie ,  Pathik Soni ,  Lei Qiao ,  Dustin House ,  Lyle Yarnell ,  Edna Prieto-Ballengee ,  Cathy Forsythe ,  Michael Shawn Murphy ,  Andrew Fischer ,  Akanksha Sharma ,  Joseph Esposito ,  Matt Effinger ,  Michael Futer

IPC分类号： A61L2/04 ,  H05B6/06 ,  H05B6/10 ,  H05B6/40 ,  A61L2/24

CPC分类号： A61L2/04 ,  A61L2/24 ,  A61L2202/14 ,  H05B6/06 ,  H05B6/101 ,  H05B6/108 ,  H05B6/14 ,  H05B6/40

摘要： Inductive heating systems and method of controlling the same to reduce biological carryover are disclosed herein. An example system includes an induction heater including a tank circuit. The example system includes a controller to drive the tank circuit to selectively oscillate at a resonant frequency for the tank circuit to inductively heat a work piece disposed proximate to the tank circuit.

公开(公告)号：US20160184823A1

公开(公告)日：2016-06-30

申请号：US14976684

申请日：2015-12-21

申请人： Abbott Laboratories

发明人： Andrew Fischer

IPC分类号： B01L3/00

CPC分类号： B01L3/502707 ,  B01L3/502792 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/089 ,  B01L2400/0427

摘要： Example methods, apparatus, systems for diluting samples are disclosed. An example method includes depositing a first fluid droplet on a first electrode of a plurality of electrodes. The first electrode has a first area. The first fluid droplet has a first volume associated with the first area. The example method includes depositing a second fluid droplet on a second electrode of the plurality of electrodes. The second electrode has a second area. The second fluid droplet has a second volume associated with the second area. The second volume is different than the first volume. The example method includes forming a combined droplet by selectively activating at least one of the first electrode or the second electrode to cause one of the first fluid droplet or the second fluid droplet to merge with the other of the first fluid droplet or the second fluid droplet.

摘要翻译： 公开了用于稀释样品的示例性方法，装置，系统。 一个示例性方法包括将第一流体液滴沉积在多个电极的第一电极上。 第一电极具有第一区域。 第一流体液滴具有与第一区域相关联的第一体积。 该示例性方法包括将第二流体液滴沉积在多个电极的第二电极上。 第二电极具有第二区域。 第二流体液滴具有与第二区域相关联的第二体积。 第二卷与第一卷不同。 该示例性方法包括通过选择性地激活第一电极或第二电极中的至少一个来形成组合的液滴，以使第一流体液滴或第二流体液滴中的一个与第一流体液滴或第二流体液滴 。

公开(公告)号：US11578358B2

公开(公告)日：2023-02-14

申请号：US16312489

申请日：2017-09-14

申请人： Abbott Laboratories

发明人： Mark A. Hayden ,  Jeffrey B. Huff ,  Sophie Laurenson ,  Andrew Fischer ,  John Robinson ,  Shelley R. Holets-McCormack

IPC分类号： C12Q1/6853

摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. The detection modules disclosed here can be used for detecting analytes of interest which analytes may have been enriched by amplification, isolation, or other techniques.

公开(公告)号：US11213817B2

公开(公告)日：2022-01-04

申请号：US16531253

申请日：2019-08-05

申请人： Abbott Laboratories

发明人： Andrew Fischer

IPC分类号： B01L3/00

摘要： Example methods, apparatus, systems for diluting samples are disclosed. An example method includes depositing a first fluid droplet on a first electrode of a plurality of electrodes. The first electrode has a first area. The first fluid droplet has a first volume associated with the first area. The example method includes depositing a second fluid droplet on a second electrode of the plurality of electrodes. The second electrode has a second area. The second fluid droplet has a second volume associated with the second area. The second volume is different than the first volume. The example method includes forming a combined droplet by selectively activating at least one of the first electrode or the second electrode to cause one of the first fluid droplet or the second fluid droplet to merge with the other of the first fluid droplet or the second fluid droplet.

公开(公告)号：US20210060549A1

公开(公告)日：2021-03-04

申请号：US17094423

申请日：2020-11-10

申请人： Abbott Laboratories

发明人： Andrew Fischer ,  Adrian Petyt ,  Sophie Laurenson

IPC分类号： B01L3/00 ,  B41J2/06 ,  H05K1/02 ,  G01N27/447

摘要： Example methods, apparatus, systems for droplet actuator fabrication are disclosed. An example non-transitory computer readable medium includes instructions that, when executed, cause at least one processor to at least control movement of a laser to cause the laser to etch an electrode pattern in a first substrate, the electrode pattern including a first set of electrodes, a second set of electrodes, and a third set of electrodes; control a printer driver to cause a hydrophobic material and a dielectric material to be applied to the second set of electrodes and not the first set of electrodes via a printer; control a bonding driver to cause a gap to be defined between the first substrate and a second substrate; and control a dicing driver to cause a portion the first substrate and a portion of the second substrate to be cut into a droplet actuator.

公开(公告)号：US20150298124A1

公开(公告)日：2015-10-22

申请号：US14687398

申请日：2015-04-15

申请人： Abbott Laboratories

发明人： Andrew Fischer ,  Adrian Petyt ,  Sophie Laurenson

IPC分类号： B01L3/00 ,  G01N27/447

CPC分类号： B01L3/50273 ,  B01L3/502738 ,  B01L2400/0424 ,  B01L2400/0427 ,  B41J2/06 ,  G01N27/44743 ,  H05K1/0269 ,  H05K1/0272 ,  H05K3/0097 ,  H05K3/027 ,  H05K3/388 ,  H05K2201/09918 ,  H05K2203/1173 ,  H05K2203/1545

摘要： Example methods, apparatus, systems for droplet actuator fabrication are disclosed. An example method disclosed herein for making a droplet actuator includes ablating a first substrate with a laser to form an electrode array on the first substrate. The example method includes applying at least one of hydrophobic or a dielectric material to the electrode array. The example method also includes aligning the first substrate with a second substrate. The second substrate includes a second treated layer. In the example method, the alignment includes a gap between at least a portion of the first treated layer and at least a portion the second treated layer.

摘要翻译： 公开了用于液滴致动器制造的示例性方法，装置，系统。 本文公开的用于制造液滴致动器的示例性方法包括用激光烧蚀第一衬底以在第一衬底上形成电极阵列。 示例性方法包括将疏水或电介质材料中的至少一种应用于电极阵列。 该示例性方法还包括将第一基板与第二基板对准。 第二基板包括第二处理层。 在示例性方法中，对准包括在第一处理层的至少一部分与第二处理层的至少一部分之间的间隙。

公开(公告)号：US20190153524A1

公开(公告)日：2019-05-23

申请号：US16312489

申请日：2017-09-14

申请人： Abbott Laboratories

发明人： Mark A. Hayden ,  Jeffrey B. Huff ,  Sophie Laurenson ,  Andrew Fischer ,  John Robinson ,  Shelley R. Holets-McCormack

IPC分类号： C12Q1/6853

摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. The detection modules disclosed here can be used for detecting analytes of interest which analytes may have been enriched by amplification, isolation, or other techniques.

公开(公告)号：US20180104694A1

公开(公告)日：2018-04-19

申请号：US15724203

申请日：2017-10-03

申请人： ABBOTT LABORATORIES

发明人： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew Fischer ,  John M. Robinson ,  Shelley R. Holets-McCormack ,  Sophie Laurenson

IPC分类号： B01L3/00 ,  G01N33/53

CPC分类号： B01L3/502784 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/142 ,  B01L2300/0829 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2300/161 ,  G01N33/5302 ,  G01N33/54373

摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.