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    DEVICES AND METHODS FOR SAMPLE ANALYSIS
    1.
    发明申请
    DEVICES AND METHODS FOR SAMPLE ANALYSIS 有权

    公开(公告)号：US20220126296A1

    公开(公告)日：2022-04-28

    申请号：US17519400

    申请日：2021-11-04

    申请人： Abbott Laboratories

    发明人： Jeffrey B. Huff ,  Mark A. Hayden ,  Graham Davis ,  Sergey Gershtein

    IPC分类号： B01L3/00 ,  G01N33/543 ,  G01N27/447

    摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. Additional analyte detection devices configured to operate an analyte detection chip to prepare a test sample and to detect an analyte related signal from the prepared test sample in the analyte detection chip are disclosed. The analyte detection chip may include a digital microfluidics (DMF) region and an analyte detection region which may overlap or may be spatially separated. The analyte detection device may be configured for detection of analyte by an optical or electrochemical means operably connected with an analyte detection chip inserted into the device.

    Devices and Methods for Sample Analysis
    2.
    发明申请
    Devices and Methods for Sample Analysis 有权

    公开(公告)号：US20210325334A1

    公开(公告)日：2021-10-21

    申请号：US17221544

    申请日：2021-04-02

    申请人： Abbott Laboratories

    发明人： Jeffrey B. Huff ,  Mark A. Hayden ,  Graham Davis ,  Sergey Gershtein

    IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N33/543 ,  C40B60/12 ,  B01L3/00 ,  C12Q1/6869 ,  G01N33/487

    摘要： Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided. Also provided herein are instruments that are programmed to operate a cartridge that includes an array of electrodes for actuating a droplet and further includes an electrochemical species sensing region. The instrument may be used to analyse a sample in a cartridge that includes an array of electrodes for actuating a droplet and further includes a nanopore layer for detecting translocation of a tag/second binding member through nanopore. An instrument configured to operate a first cartridge that includes an array of electrodes for actuating a droplet and further includes an electrochemical species sensing region and a second cartridge that includes an array of electrodes for actuating a droplet and further includes a nanopore layer for detecting translocation of a tag/second binding member through nanopore is disclosed. An instrument configured to operate a cartridge that includes an array of electrodes for actuating a droplet, an electrochemical species sensing region, and a nanopore layer for detecting translocation of a tag/second binding member through nanopore is disclosed.

    Devices and methods for sample analysis
    7.
    发明授权
    Devices and methods for sample analysis 有权

    公开(公告)号：US11198129B2

    公开(公告)日：2021-12-14

    申请号：US15726280

    申请日：2017-10-05

    申请人： Abbott Laboratories

    发明人： Jeffrey B. Huff ,  Mark A. Hayden ,  Graham Davis ,  Sergey Gershtein

    IPC分类号： G01N33/543 ,  G01N27/447 ,  G01N27/327 ,  B01L3/00

    摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. Additonal analyte detection devices configured to operate an analyte detection chip to prepare a test sample and to detect an analyte related signal from the prepared test sample in the analyte detection chip are disclosed. The analyte detection chip may include a digital microfluidics (DMF) region and an analyte detection region which may overlap or may be spatially separated. The analyte detection device may be configured for detection of analyte by an optical or electrochemical means operably connected with an analyte detection chip inserted into the device.

    METHODS AND DEVICES FOR SAMPLE ANALYSIS
    8.
    发明申请
    METHODS AND DEVICES FOR SAMPLE ANALYSIS 审中-公开

    公开(公告)号：US20200001300A1

    公开(公告)日：2020-01-02

    申请号：US16421210

    申请日：2019-05-23

    申请人： Abbott Laboratories ,  The Katholieke Universiteit Leuven (Ku Leuven)

    发明人： Mark A. Hayden ,  Karen Leirs ,  Elena Pérez-Ruiz ,  Jeroen Lammertyn

    IPC分类号： B01L3/00 ,  G01N33/543

    摘要： Methods for detecting target analytes utilizing an array of wells are advantageous for detection of low concentrations of target analytes. Use of an array of wells requires sealing of the wells. The methods provided herein utilize digital microfluidics to seal wells of an array with a fluid that is immiscible with the aqueous liquid present in the wells to prevent evaporation and contamination of the aqueous fluid during analysis of signals from the wells. The disclosed method include generating a biphasic droplet composed of the immiscible fluid and an aqueous fluid. The immiscible fluid present in the biphasic droplet is moved over the array of wells to seal the wells by electrically actuating the aqueous fluid present in the biphasic droplet which in turn pulls the immiscible fluid.

    Devices and methods for sample analysis
    9.
    发明授权
    Devices and methods for sample analysis 有权

    公开(公告)号：US11578358B2

    公开(公告)日：2023-02-14

    申请号：US16312489

    申请日：2017-09-14

    申请人： Abbott Laboratories

    发明人： Mark A. Hayden ,  Jeffrey B. Huff ,  Sophie Laurenson ,  Andrew Fischer ,  John Robinson ,  Shelley R. Holets-McCormack

    IPC分类号： C12Q1/6853

    摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. The detection modules disclosed here can be used for detecting analytes of interest which analytes may have been enriched by amplification, isolation, or other techniques.

    Devices and methods for sample analysis
    10.
    发明授权
    Devices and methods for sample analysis 有权

    公开(公告)号：US11369963B2

    公开(公告)日：2022-06-28

    申请号：US16850711

    申请日：2020-04-16

    申请人： Abbott Laboratories

    发明人： Jeffrey B. Huff ,  Mark A. Hayden ,  Graham Davis ,  Sergey Gershtein

    IPC分类号： B01L3/00 ,  G01N27/447 ,  G01N33/543 ,  G01N27/327

    摘要： Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells. Additional analyte detection devices configured to operate an analyte detection chip to prepare a test sample and to detect an analyte related signal from the prepared test sample in the analyte detection chip are disclosed. The analyte detection chip may include a digital microfluidics (DMF) region and an analyte detection region which may overlap or may be spatially separated. The analyte detection device may be configured for detection of analyte by an optical or electrochemical means operably connected with an analyte detection chip inserted into the device.