公开(公告)号：US20230258638A1

公开(公告)日：2023-08-17

申请号：US18045845

申请日：2022-10-12

申请人： Abbott Laboratories

发明人： A. Scott Muerhoff ,  John C. Prostko ,  James L. Stewart ,  Mary A. RODGERS ,  Gavin A. CLOHERTY ,  James Hartnett ,  Jeff Moore ,  Kathy Otis ,  Alak Kar ,  Bailin Tu ,  Bryan Tieman ,  Carolyn Strobel ,  David Hawksworth ,  Robert Ziemann ,  Zhihong Lin ,  Chris Marohnic ,  Peter Wiebe ,  Todd Meyer ,  Weijie Jiao ,  Gangamani S. Beligere ,  Saminathan X. Muthusamy ,  Jessica L. Grieshaber ,  Sandra K. Pearce ,  Edwin C. Frias ,  Russell E. Taylor ,  Kelly Coller ,  Yangrong E. Zhang ,  Thomas T. Biegalski ,  David J. Daghfal ,  Claudio Galli ,  Sergey Y. Tetin ,  Qiaoqiao Ruan ,  Patrick MacDonald ,  Michael S. Cassidy ,  Mary E. Gardiner ,  Mary Ann P. Palafox ,  Matthew S. Matias ,  Melissa B. Brennan ,  Philip W. Schultz ,  Beth C. Trudeau

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/165 ,  G01N2469/20 ,  G01N2800/52

摘要： Disclosed herein are methods, kits, systems, algorithms and improvements for detecting the presence of or determining an amount, quantity, concentration and/or level of an antibody against at least one type of β-coronavirus, such as, for example, an antibody against SARS-CoV or SARS-CoV-2, in one or more samples obtained from a subject. In some aspects, the methods, kits and systems relate to detecting the presence of or determining an amount, quantity, concentration and/or level of at least one type of anti-β-coronavirus antibody, such as an IgG and/or IgM antibody, in one or more samples obtained from a subject. The methods, kits systems, algorithms and improvements can also be used to monitor a subject's response and/or treatment to a β-coronavirus, determine whether or not a subject will develop or experience a cytokine storm, predict outcome in a subject, determine whether a subject can be administered a vaccine for a β-coronavirus, monitoring antibody response in individuals that have received a β-coronavirus vaccine (such as a SARS-CoV-2 vaccine), and/or determine the immune status of a subject.