公开(公告)号：US10308709B2

公开(公告)日：2019-06-04

申请号：US15290762

申请日：2016-10-11

申请人： ABBOTT LABORATORIES

发明人： Bailin Tu ,  Robert N. Ziemann ,  Bryan C. Tieman ,  Philip M. Hemken ,  Carol S. Ramsay ,  Carolyn J. Strobel ,  David J. Hawksworth ,  Larry G. Birkenmeyer ,  Cheng Zhao ,  Susan E. Brophy ,  Barry L. Dowell ,  Anthony S. Muerhoff

IPC分类号： G01N33/53 ,  C07K16/18 ,  G01N33/574 ,  G01N33/68

摘要： Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.

公开(公告)号：US20190162726A1

公开(公告)日：2019-05-30

申请号：US16237106

申请日：2018-12-31

申请人： Abbott Laboratories

发明人： David J. Hawksworth ,  Robert W. Siegel ,  Bryan C. Tieman ,  Bailin Tu ,  Susan E. Brophy ,  Dinesh O. Shah ,  Joan D. Tyner ,  Robert N. Ziemann

IPC分类号： G01N33/569 ,  C07K16/20

摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

公开(公告)号：US09469686B2

公开(公告)日：2016-10-18

申请号：US13836229

申请日：2013-03-15

申请人： Abbott Laboratories

发明人： Bailin Tu ,  Robert N. Ziemann ,  Bryan C. Tieman ,  Philip M. Hemken ,  Carol S. Ramsay ,  Carolyn J. Strobel ,  David J. Hawksworth ,  Larry G. Birkenmeyer ,  Cheng Zhao ,  Susan E. Brophy ,  Barry L. Dowell ,  Anthony S. Muerhoff

IPC分类号： C07K16/00 ,  A61K39/395 ,  C07K16/18 ,  G01N33/574 ,  G01N33/68

CPC分类号： C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2800/085 ,  G01N2800/50

摘要： Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.

摘要翻译： 本文公开了使用所述抗体检测样品中的高尔基体蛋白73（GP73）和岩藻糖基化GP73的抗体和方法。

公开(公告)号：US09482667B2

公开(公告)日：2016-11-01

申请号：US14686351

申请日：2015-04-14

申请人： Abbott Laboratories

发明人： Susan E. Brophy ,  David J. Hawksworth ,  Dinesh O. Shah ,  Robert W. Siegel ,  Bryan C. Tieman ,  Bailin Tu ,  Joan D. Tyner ,  Robert N. Ziemann

IPC分类号： G01N33/53 ,  C07K16/20 ,  G01N33/569

CPC分类号： G01N33/56905 ,  C07K16/20 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/44 ,  G01N2469/10 ,  G01N2469/20 ,  G01N2496/00

摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

公开(公告)号：US20130295593A1

公开(公告)日：2013-11-07

申请号：US13726219

申请日：2012-12-23

申请人： ABBOTT LABORATORIES

发明人： Christian Beckert ,  Susan E. Brophy ,  Jonathan Grote ,  Dagang Huang ,  Jan Schultess ,  Bailin Tu

IPC分类号： G01N33/82 ,  C07K14/47

CPC分类号： G01N33/82 ,  C07K14/47 ,  C07K14/76 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/40 ,  G01N33/543

摘要： Vitamin D binding proteins (DBP), in particular truncated DBP and mutated, truncated DBP, as well as fusion proteins thereof, nucleic acid molecules encoding same, vectors, host cells, and methods, kits and solid supports for determining the total amount of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in a test sample.

摘要翻译： 维生素D结合蛋白（DBP），特别是截短的DBP和突变的截短的DBP，以及其融合蛋白，编码相同的核酸分子，载体，宿主细胞和方法，试剂盒和固体支持物，用于确定总量为25 - 羟基维生素D2和25-羟基维生素D3。

公开(公告)号：US10215754B2

公开(公告)日：2019-02-26

申请号：US15287605

申请日：2016-10-06

申请人： Abbott Laboratories

发明人： Susan E. Brophy ,  David J. Hawksworth ,  Dinesh O. Shah ,  Robert W. Siegel ,  Bryan C. Tieman ,  Bailin Tu ,  Joan D. Tyner ,  Robert N. Ziemann

IPC分类号： C07K16/20 ,  G01N33/569

摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

公开(公告)号：US20150212083A1

公开(公告)日：2015-07-30

申请号：US14686351

申请日：2015-04-14

申请人： Abbott Laboratories

发明人： Susan E. Brophy ,  David J. Hawksworth ,  Dinesh O. Shah ,  Robert W. Siegel ,  Bryan C. Tieman ,  Bailin Tu ,  Joan D. Tyner ,  Robert N. Ziemann

IPC分类号： G01N33/569 ,  C07K16/20

CPC分类号： G01N33/56905 ,  C07K16/20 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/44 ,  G01N2469/10 ,  G01N2469/20 ,  G01N2496/00

摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

摘要翻译： 本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。

公开(公告)号：US20190315844A1

公开(公告)日：2019-10-17

申请号：US16387282

申请日：2019-04-17

申请人： ABBOTT LABORATORIES

发明人： Bailin Tu ,  Robert N. Ziemann ,  Bryan C. Tieman ,  Philip M. Hemken ,  Carol S. Ramsay ,  Carolyn J. Strobel ,  David J. Hawksworth ,  Larry G. Birkenmeyer ,  Cheng Zhao ,  Susan E. Brophy ,  Barry L. Dowell ,  Anthony S. Muerhoff

IPC分类号： C07K16/18 ,  G01N33/574 ,  G01N33/68

摘要： Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.

公开(公告)号：US20170023568A1

公开(公告)日：2017-01-26

申请号：US15287605

申请日：2016-10-06

申请人： Abbott Laboratories

发明人： Susan E. Brophy ,  David J. Hawksworth ,  Dinesh O. Shah ,  Robert W. Siegel ,  Bryan C. Tieman ,  Bailin Tu ,  Joan D. Tyner ,  Robert N. Ziemann

IPC分类号： G01N33/569 ,  C07K16/20

CPC分类号： G01N33/56905 ,  C07K16/20 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/44 ,  G01N2469/10 ,  G01N2469/20 ,  G01N2496/00

摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

摘要翻译： 本公开涉及使用试剂检测克氏锥虫的表位的试剂和方法。

公开(公告)号：US20230258638A1

公开(公告)日：2023-08-17

申请号：US18045845

申请日：2022-10-12

申请人： Abbott Laboratories

发明人： A. Scott Muerhoff ,  John C. Prostko ,  James L. Stewart ,  Mary A. RODGERS ,  Gavin A. CLOHERTY ,  James Hartnett ,  Jeff Moore ,  Kathy Otis ,  Alak Kar ,  Bailin Tu ,  Bryan Tieman ,  Carolyn Strobel ,  David Hawksworth ,  Robert Ziemann ,  Zhihong Lin ,  Chris Marohnic ,  Peter Wiebe ,  Todd Meyer ,  Weijie Jiao ,  Gangamani S. Beligere ,  Saminathan X. Muthusamy ,  Jessica L. Grieshaber ,  Sandra K. Pearce ,  Edwin C. Frias ,  Russell E. Taylor ,  Kelly Coller ,  Yangrong E. Zhang ,  Thomas T. Biegalski ,  David J. Daghfal ,  Claudio Galli ,  Sergey Y. Tetin ,  Qiaoqiao Ruan ,  Patrick MacDonald ,  Michael S. Cassidy ,  Mary E. Gardiner ,  Mary Ann P. Palafox ,  Matthew S. Matias ,  Melissa B. Brennan ,  Philip W. Schultz ,  Beth C. Trudeau

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/165 ,  G01N2469/20 ,  G01N2800/52

摘要： Disclosed herein are methods, kits, systems, algorithms and improvements for detecting the presence of or determining an amount, quantity, concentration and/or level of an antibody against at least one type of β-coronavirus, such as, for example, an antibody against SARS-CoV or SARS-CoV-2, in one or more samples obtained from a subject. In some aspects, the methods, kits and systems relate to detecting the presence of or determining an amount, quantity, concentration and/or level of at least one type of anti-β-coronavirus antibody, such as an IgG and/or IgM antibody, in one or more samples obtained from a subject. The methods, kits systems, algorithms and improvements can also be used to monitor a subject's response and/or treatment to a β-coronavirus, determine whether or not a subject will develop or experience a cytokine storm, predict outcome in a subject, determine whether a subject can be administered a vaccine for a β-coronavirus, monitoring antibody response in individuals that have received a β-coronavirus vaccine (such as a SARS-CoV-2 vaccine), and/or determine the immune status of a subject.