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公开(公告)号：US5453265A
公开(公告)日：1995-09-26
申请号：US181525
申请日：1994-01-13
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Drum Stringer , Michael Prencipe
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Drum Stringer , Michael Prencipe
CPC分类号： A61K8/24 , A61K8/347 , A61K8/42 , A61K8/8164 , A61Q11/00 , A61K2800/87
摘要： An oral composition dentifrice containing an orally acceptable vehicle, about 30-75% by weight of a dentally acceptable water-insoluble polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan) an antibacterial enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, and a surface active agent and/or a flavoring oil.
摘要翻译： 含有口服可接受的载体的口服组合物洁齿剂，约30-75重量％的牙齿可接受的水不溶性抛光剂，基本上不溶于水的非阳离子抗菌抗斑剂如2,4,4'-三氯-2' - 羟基 - 二苯基醚（三氯生）抗菌增强剂，其增强了所述抗菌剂向口腔表面和表面活性剂和/或调味油的输送和保留。
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公开(公告)号：US5312618A
公开(公告)日：1994-05-17
申请号：US984629
申请日：1992-12-02
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer , Michael Prencipe
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer , Michael Prencipe
CPC分类号： A61Q11/00 , A61K8/347 , A61K8/42 , A61K8/8164
摘要： An oral composition dentifrice containing an orally acceptable vehicle, about 30-75% by weight of a dentally acceptable water-insoluble polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2.sup.1 -hydroxy-diphenyl ether (triclosan) an antibacterial enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, and a surface active agent and/or a flavoring oil.
摘要翻译： 含有口服可接受的载体的口服组合物洁齿剂，约30-75重量％的牙齿可接受的水不溶性抛光剂，基本上不溶于水的非阳离子抗菌抗斑剂如2,4,4'-三氯-21- 羟基二苯基醚（三氯生）是增强所述抗菌剂向口腔表面和表面活性剂和/或调味油的输送和保留的抗菌增强剂。
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公开(公告)号：US5192531A
公开(公告)日：1993-03-09
申请号：US758345
申请日：1991-09-09
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer , Michael Prencipe
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer , Michael Prencipe
CPC分类号： A61K8/347 , A61K8/42 , A61K8/8164 , A61Q11/00
摘要： An oral composition dentifrice containing an orally acceptable vehicle, about 30-75% by weight of a dentally acceptable water-insoluble polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan) an antibacterial enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, and a surface active agent and/or a flavoring oil.
摘要翻译： 含有口服可接受的载体的口服组合物洁齿剂，约30-75重量％的牙齿可接受的水不溶性抛光剂，基本上不溶于水的非阳离子抗菌抗斑剂如2,4,4'-三氯-2' - 羟基 - 二苯基醚（三氯生）抗菌增强剂，其增强了所述抗菌剂向口腔表面和表面活性剂和/或调味油的输送和保留。
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公开(公告)号：US5292526A
公开(公告)日：1994-03-08
申请号：US966104
申请日：1992-10-23
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/347 , A61K8/42 , A61K8/8164 , Y10S526/936
摘要： An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Triclosan). Antiplaque effectiveness is optimized by the presence of an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
摘要翻译： 口服组合物如洁牙剂，漱口剂，锭剂或口香糖，其含有多磷酸抗结石剂，例如四碱金属焦磷酸盐和与其相容的抗菌抗菌剂。 抗牙斑剂是基本上不溶于水的非阳离子抗菌剂，例如2,4,4'-三氯-2'-羟基二苯醚（三氯生）。 通过抗增生剂的存在来优化抗斑效果，其增强了所述抗菌剂在口腔表面上的输送和保留。
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公开(公告)号：US5275805A
公开(公告)日：1994-01-04
申请号：US075255
申请日：1993-06-11
申请人： Nuran Nabi , Abdul Gaffar , John Afflitto
发明人： Nuran Nabi , Abdul Gaffar , John Afflitto
IPC分类号： A61K8/00 , A61K20060101 , A61K8/42 , A61K8/46 , A61K8/86 , A61K8/90 , A61K31/80 , A61P1/02 , A61Q11/00 , A61K7/16 , A61K7/22
摘要： An antiplaque oral composition such as a gel, paste or mouthrinse which is comprised of a vehicle having incorporated therein as the antiplaque agent an effective amount of an antibacterial salicylanilide compound and a surfactant mixture of an anionic surfactant, a polyoxyethylene/polyoxypropylene block copolymer and a taurate salt, the pH of the composition being adjusted to a pH of at least 8.0. An antibacterial-enhancing agent such as an anionic polymeric polycarboxylate which enhances the delivery of the salicylanilide compound to and retention on oral tissue surfaces is optionally incorporated in the composition to improve the efficacy of the salicylanilide compound.
摘要翻译： 一种防斑口服组合物，例如凝胶，糊剂或漱口水，其由其中掺入抗牙斑剂的载体组成，有效量的抗菌水杨酰苯胺化合物和阴离子表面活性剂，聚氧乙烯/聚氧丙烯嵌段共聚物和 牛磺酸盐，将组合物的pH调节至至少8.0的pH。 任选地在组合物中引入增强将水杨酰苯胺化合物递送到口腔组织表面上并保留在口腔组织表面上的抗菌增强剂如阴离子聚合多羧酸盐，以提高水杨酰苯胺化合物的功效。
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公开(公告)号：US5192530A
公开(公告)日：1993-03-09
申请号：US754887
申请日：1991-09-06
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
摘要： An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan), and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, wherein said antiplaque agent is substantially completely dissolved in saliva present during tooth and gum cleaning in a solubilizing agent therefor. The solubilizing agent may be a humectant polyol such as propylene glycol, dipropylene glycol and hexylene glycol; a cellosolve such as methyl cellosolve and ethyl cellosolve; a vegetable oil or wax containing at least about 12 carbon atoms in a straight chain such as olive oil, castor oil and petrolatum; or an ester such as ethyl acetate, amyl acetate, glyceryl tristearate and benzyl benzoate.
摘要翻译： 一种口服组合物洁齿剂，其包含口服可接受的载体，约5-30重量％的硅质抛光剂，基本上不溶于水的非阳离子抗菌抗斑剂如2,4,4'-三氯-2'-羟基二苯醚（ 三氯生）和增强所述抗菌剂输送到其口腔表面上的抗菌增强剂，其中所述抗牙斑剂在牙齿和牙龈清洁过程中基本上完全溶解在存在的唾液中，用于增溶剂。 增溶剂可以是保湿多元醇，例如丙二醇，二丙二醇和己二醇; 溶纤剂如甲基溶纤剂和乙基溶纤剂; 在直链如橄榄油，蓖麻油和凡士林中含有至少约12个碳原子的植物油或蜡; 或酯如乙酸乙酯，乙酸戊酯，三硬脂酸甘油酯和苯甲酸苄酯。
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公开(公告)号：US5728756A
公开(公告)日：1998-03-17
申请号：US668754
申请日：1996-06-24
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
CPC分类号： C08F230/02 , A61K8/24 , A61K8/347 , A61K8/42 , A61K8/81 , A61K8/8164 , A61Q11/00 , A61K2800/87
摘要： An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan), and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, wherein said antiplaque agent is substantially completely dissolved in saliva present during tooth and gum cleaning in a solubilizing agent therefor. The solubilizing agent may be a humectant polyol such as propylene glycol, dipropylene glycol and hexylene glycol; a cellosolve such as methy cellosolve and ethyl cellosolve: a vegetable oil or wax containing at least about 12 carbon atoms in a straight chain such as olive oil, castor oil and petrolatum; or an ester such as ethyl acetate, amyl acetate, glyceryl tristearate and benzyl benzoate.
摘要翻译： 一种口服组合物洁齿剂，其包含口服可接受的载体，约5-30重量％的硅质抛光剂，基本上不溶于水的非阳离子抗菌抗斑剂如2,4,4'-三氯-2'-羟基二苯醚（ 三氯生）和增强所述抗菌剂输送到其口腔表面上的抗菌增强剂，其中所述抗牙斑剂在牙齿和牙龈清洁过程中基本上完全溶解在存在的唾液中，用于增溶剂。 增溶剂可以是保湿多元醇，例如丙二醇，二丙二醇和己二醇; 溶纤剂如甲基溶纤剂和乙基溶纤剂：在直链如橄榄油，蓖麻油和凡士林中含有至少约12个碳原子的植物油或蜡; 或酯如乙酸乙酯，乙酸戊酯，三硬脂酸甘油酯和苯甲酸苄酯。
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公开(公告)号：US5686064A
公开(公告)日：1997-11-11
申请号：US187984
申请日：1994-01-28
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/347 , A61K8/42 , A61K8/8164 , Y10S526/936
摘要： An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Triclosan). Antiplaque effectiveness is optimized by the presence of an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
摘要翻译： 口服组合物如洁牙剂，漱口剂，锭剂或口香糖，其含有多磷酸抗结石剂，例如四碱金属焦磷酸盐和与其相容的抗菌抗菌剂。 抗牙斑剂是基本上不溶于水的非阳离子抗菌剂，例如2,4,4'-三氯-2'-羟基二苯醚（三氯生）。 通过抗增生剂的存在来优化抗斑效果，其增强了所述抗菌剂在口腔表面上的输送和保留。
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公开(公告)号：US5180578A
公开(公告)日：1993-01-19
申请号：US657885
申请日：1991-02-19
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
CPC分类号： A61Q11/00 , A61K8/24 , A61K8/347 , A61K8/42 , A61K8/8164 , Y10S526/936
摘要： An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Triclosan). Antiplaque effectiveness is optimized by the presence of an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
摘要翻译： 口服组合物如洁牙剂，漱口剂，锭剂或口香糖，其含有多磷酸抗结石剂，例如四碱金属焦磷酸盐和与其相容的抗菌抗菌剂。 抗牙斑剂是基本上不溶于水的非阳离子抗菌剂，例如2,4,4'-三氯-2'-羟基二苯醚（三氯生）。 通过抗增生剂的存在来优化抗斑效果，其增强了所述抗菌剂在口腔表面上的输送和保留。
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公开(公告)号：US5178851A
公开(公告)日：1993-01-12
申请号：US655571
申请日：1991-02-14
申请人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
发明人： Abdul Gaffar , Nuran Nabi , John Afflitto , Orum Stringer
CPC分类号： A61K8/8164 , A61K8/24 , A61K8/347 , A61K8/42 , A61Q11/00 , Y10S526/936
摘要： An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25-0.35% by weight of a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
摘要翻译： 一种口服组合物洁齿剂，其包含口服可接受的载体，约5-30重量％的硅质抛光剂，约0.25-0.35重量％的基本上不溶于水的非阳离子抗菌抗斑剂，例如2,4,4'- 三氯-2'-羟基二苯醚（三氯生）和增强所述抗菌剂的输送和保留在口腔表面上的抗菌增强剂。
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