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公开(公告)号：US20230271970A1
公开(公告)日：2023-08-31
申请号：US18018012
申请日：2021-07-22
发明人： Yong Qin , Wu Zhong , Fei Xue , Minjie Zhang , Shiyong Fan , Zhibing Zheng , Song Li
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to the technical field of chemical drug synthesis, and specifically relates to a method for preparing a compound as shown in formula I, comprising: treating the compound as shown in formula VII with an acid to generate the compound as shown in formula I. The method has few synthetic process steps, raw materials which is stable and is easy to prepare, a reaction process which is easy to control, and a high overall yield and purity, and is suitable for industrial preparation.
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公开(公告)号：US11180463B2
公开(公告)日：2021-11-23
申请号：US16382539
申请日：2019-04-12
发明人： Song Li , Wu Zhong , Shuang Cao , Lili Wang , Zhibing Zheng , Junhai Xiao , Xinbo Zhou
IPC分类号： C07D277/22 , A61K31/426 , C07D277/30 , A61K8/49 , A61K31/4422 , A61Q11/00 , A61Q19/08
摘要： The present invention pertains to field of pharmaceutical chemicals, and relates to thiazole inner salt compounds, preparation methods and uses thereof. Specifically, the present invention relates to a compound of Formula I, hydrates or pharmaceutically acceptable salts thereof. The compound of Formula I of the present invention is a potent cross-linking protein cleavage agent, has a stable structure, good physical and chemical properties, and good pharmacological activities, and is suitable for large scale production to obtain samples with stable, controllable and reliable quality, thereby being suitable for pharmaceutical development.
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公开(公告)号：US10301279B2
公开(公告)日：2019-05-28
申请号：US15794666
申请日：2017-10-26
发明人： Wu Zhong , Song Li , Yanqun Zeng , Junhai Xiao , Xinbo Zhou , Zhibing Zheng , Xingzhou Li , Xiaokui Wang
IPC分类号： A61K31/506 , C07D401/04 , C07D401/14 , C07D409/14 , A61K45/06 , A61K31/404 , A61K31/454 , A61K31/4545 , A61K31/517 , A61K31/5377
摘要： The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.
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公开(公告)号：US10196411B2
公开(公告)日：2019-02-05
申请号：US15539266
申请日：2015-12-11
发明人： Song Li , Xingzhou Li , Wu Zhong , Zhibing Zheng , Junhai Xiao , Xinbo Zhou , Yunde Xie , Xiaokui Wang , Lili Wang , Wei Chen , Fei Xie
IPC分类号： C07D277/58 , C07F9/6539 , A61K31/426 , A61K31/675 , A61P31/20 , A61P31/14 , A61P31/16 , A61P31/06 , A61P33/02 , A61P33/04 , A61P33/10 , A61P1/00
摘要： The invention relates to tizoxanide phosphate or alkane sulfonate compounds represented by Formula I, and pharmaceutically acceptable salts thereof, isomers thereof, hydrates thereof or solvates thereof, and pharmaceutical applications of the compounds.
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公开(公告)号：US09630957B2
公开(公告)日：2017-04-25
申请号：US14893391
申请日：2014-05-28
发明人： Song Li , Junhai Xiao , Xian Zhang , Wu Zhong , Zhibing Zheng , Lili Wang , Yunde Xie , Xingzhou Li , Xinbo Zhou , Xiaokui Wang
IPC分类号： C07D417/12 , C07D303/48 , C07D417/14
CPC分类号： C07D417/12 , C07D303/48 , C07D417/14
摘要： Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses.
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![(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof](/abs-image/US/2016/12/13/US09518008B2/abs.jpg.150x150.jpg)
6.发明授权(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof 有权（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4- uan基-2-羟基 - 环戊基-1-羧酸水合物公开(公告)号：US09518008B2
公开(公告)日：2016-12-13
申请号：US14511783
申请日：2014-10-10
发明人： Song Li , Wu Zhong , Zhibing Zheng , Xinbo Zhou , Junhai Xiao , Yunde Xie , Lili Wang , Xingzhou Li , Guoming Zhao , Xiaokui Wang , Hongying Liu
IPC分类号： A61K31/196 , C07C279/16 , C07C277/08 , A61P31/16 , C07C277/06
CPC分类号： C07C279/16 , C07B2200/07 , C07C277/06 , C07C277/08 , C07C2601/08
摘要： The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.
摘要翻译： 本发明涉及（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4-胍基-2-羟基 - 环戊基-1-羧酸水合物， 其制备方法，含有所述化合物的药物组合物及其制备方法，以及所述化合物作为抗流感病毒的神经脒酶抑制剂的临床应用。
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![(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-l-carboxylic acid hydrates pharmaceutical uses thereof](/abs-image/US/2016/03/01/US09272992B2/abs.jpg.150x150.jpg)
7.发明授权(1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-l-carboxylic acid hydrates pharmaceutical uses thereof 有权（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4-胍基-2-羟基 - 环戊基-1-羧酸水合物公开(公告)号：US09272992B2
公开(公告)日：2016-03-01
申请号：US13968645
申请日：2013-08-16
发明人： Song Li , Wu Zhong , Zhibing Zheng , Xinbo Zhou , Junhai Xiao , Yunde Xie , Lili Wang , Xingzhou Li , Guoming Zhao , Xiaokui Wang , Hongying Liu
IPC分类号： A61K31/24 , A01N37/12 , A01N37/44 , C07C279/16 , C07C277/06 , C07C277/08
CPC分类号： C07C279/16 , C07B2200/07 , C07C277/06 , C07C277/08 , C07C2601/08
摘要： The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds and preparing methods thereof, and the clinical uses of said compounds as neuramidinase inhibitors for anti-influenza.
摘要翻译： 本发明涉及（1S，2S，3S，4R）-3 - [（1S）-1-乙酰氨基-2-乙基 - 丁基] -4-胍基-2-羟基 - 环戊基-1-羧酸水合物， 其制备方法，含有所述化合物的药物组合物及其制备方法，以及所述化合物作为抗流感病毒的神经脒酶抑制剂的临床应用。
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公开(公告)号：US10131643B2
公开(公告)日：2018-11-20
申请号：US14901805
申请日：2014-07-04
发明人： Song Li , Xingzhou Li , Wu Zhong , Zhibing Zheng , Junhai Xiao , Xinbo Zhou , Yunde Xie , Xiaokui Wang , Lili Wang , Wei Chen , Fei Xie
IPC分类号： C07D277/58 , C07D401/12 , C07D417/12
摘要： The invention relates to a tizoxanide carbamate compound of Formula I and a pharmaceutically acceptable salt, a hydrate or a solvate thereof, and their pharmaceutical use.
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公开(公告)号：US10023565B2
公开(公告)日：2018-07-17
申请号：US15105702
申请日：2014-12-19
发明人： Wu Zhong , Song Li , Yanqun Zeng , Junhai Xiao , Xinbo Zhou , Zhibing Zheng , Xingzhou Li , Xiaokui Wang , Lili Wang
IPC分类号： A61K31/454 , A61K31/506 , C07D401/04 , C07D417/06 , A61K45/06
摘要： The present invention relates to a compound of formula (I), a stereomeride, pharmaceutically acceptable salt, a solvate or an N-oxide thereof, a medicine composition comprising the compound, a method for preparing the compound, and a usage of the compound in treating diseases related to Hsp70. The diseases are preferably selected from tumors, neurodegenerative diseases, and allogeneic transplantation rejection and infection.
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公开(公告)号：US09630939B2
公开(公告)日：2017-04-25
申请号：US14766680
申请日：2013-12-10
发明人： Song Li , Junhai Xiao , Mingming Zhao , Wu Zhong , Lili Wang , Zhibing Zheng , Yunde Xie , Xingzhou Li , Guoming Zhao , Xinbo Zhou , Xiaokui Wang , Wei Chen
IPC分类号： C07D307/33 , A61K31/365 , A61K45/06
CPC分类号： C07D307/33 , A61K31/365 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： A derivative of homoserine lactone represented by formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
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