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    Methods of treating symptoms of coronavirus infection with viral protease inhibitors
    2.
    发明授权
    Methods of treating symptoms of coronavirus infection with viral protease inhibitors 有权

    公开(公告)号：US12083099B2

    公开(公告)日：2024-09-10

    申请号：US17513284

    申请日：2021-10-28

    申请人： Accencio LLC

    发明人： Kevin Brown ,  Kevin Brogle

    IPC分类号： A61K31/4709 ,  A61K9/00 ,  A61K31/407

    CPC分类号： A61K31/407 ,  A61K9/0014 ,  A61K31/4709

    摘要： The present disclosure relates to a method of reducing or arresting viral load in a subject infected with a coronavirus, the method comprising the step of administering to the subject a therapeutically effective amount of a viral protease inhibitor. In some embodiments, the subject is a human. In one embodiment, the coronavirus is SARS-COV-19 and the viral protease inhibitor is E)-N-(4-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide; (R)-3-((2S,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-phenylbutanoyl)-5,5-dimethyl-N-(2-methylbenzyl)thiazolidine-4-carboxamide; R)—N-allyl-3-((2S,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-phenylbutanoyl)-5,5-dimethylthiazolidine-4-carboxamide; (4-((N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)methyl)-2-fluorophenyl)boronic acid or salts thereof.

    SYSTEM AND METHOD FOR EVALUATING BIOLOGICAL DATA USING AND APPLYING A VIRTUAL LANDSCAPE
    3.
    发明申请
    SYSTEM AND METHOD FOR EVALUATING BIOLOGICAL DATA USING AND APPLYING A VIRTUAL LANDSCAPE 有权

    公开(公告)号：US20220223232A1

    公开(公告)日：2022-07-14

    申请号：US17571840

    申请日：2022-01-10

    申请人： Accencio LLC

    发明人： Kevin Brown ,  Kevin Brogle

    IPC分类号： G16B40/30 ,  G16B30/00 ,  G16B50/30 ,  G06K9/62

    摘要： The present invention is directed to generating an n-dimensional map using the results of a query for compounds enumerated within a collection of documents describing a particular biological target of interest and a curated set of sequences, such as but not limited to, protein or nucleotide sequences not enumerated in the collection of documents. Both sets of sequences (document coded and curated coded) are converted into coded forms and placed in the n-dimensional map. One or more processors are configured to evaluate the distance between the curated coded forms and the closest cluster of document coded forms. Based on the distance between a coded form and the document coded forms, the curated coded forms can be ranked regarding the likelihood of interacting with the particular biological target.

    METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION WITH VIRAL PROTEASE INHIBITORS
    6.
    发明申请
    METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION WITH VIRAL PROTEASE INHIBITORS 有权

    公开(公告)号：US20230113114A1

    公开(公告)日：2023-04-13

    申请号：US17513284

    申请日：2021-10-28

    申请人： Accencio LLC

    发明人： Kevin Brown ,  Kevin Brogle

    IPC分类号： A61K31/407 ,  A61K9/00 ,  A61K31/4709

    摘要： The present disclosure relates to a method of reducing or arresting viral load in a subject infected with a coronavirus, the method comprising the step of administering to the subject a therapeutically effective amount of a viral protease inhibitor. In some embodiments, the subject is a human. In one embodiment, the coronavirus is SARS-CoV-19 and the viral protease inhibitor is E)-N-(4-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxystyryl)phenyl)methanesulfonamide; (R)-3-((2S,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-phenylbutanoyl)-5,5-dimethyl-N-(2-methylbenzyl)thiazolidine-4-carboxamide; R)—N-allyl-3-((2S,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-phenylbutanoyl)-5,5-dimethylthiazolidine-4-carboxamide; (4-((N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)methyl)-2-fluorophenyl)boronic acid or salts thereof.

    SYSTEM AND METHOD FOR EVALUATING CHEMICAL COMPOUND DATA USING AND APPLYING A VIRTUAL LANDSCAPE
    7.
    发明申请
    SYSTEM AND METHOD FOR EVALUATING CHEMICAL COMPOUND DATA USING AND APPLYING A VIRTUAL LANDSCAPE 有权

    公开(公告)号：US20220027374A1

    公开(公告)日：2022-01-27

    申请号：US17383024

    申请日：2021-07-22

    申请人： Accencio LLC

    发明人： Kevin Brown ,  Kevin Brogle

    IPC分类号： G06F16/2457 ,  G06F16/25 ,  G06F16/22 ,  G06F16/248 ,  G06N20/00 ,  G01N35/00

    摘要： The present invention is directed to generating an n-dimensional map using the results of a query for compounds enumerated within a collection of documents describing a particular biological target of interest and a curated set of compounds not enumerated in the collection of documents. Both sets of compounds (document coded and curated coded) are converted into coded forms and placed in the n-dimensional map. One or more processors are configured to evaluate the distance between the curated coded forms and the closest cluster of document coded forms. Based on the distance between a coded form and the document coded forms, the curated coded forms can be ranked regarding the likelihood of interacting with the particular biological target.