公开(公告)号：US20220107330A1

公开(公告)日：2022-04-07

申请号：US17644064

申请日：2021-12-13

Applicant: Access Medical Systems, LTD.

Inventor： Hong TAN ,  Ming XIA ,  Yushan TAN ,  Jun CHEN ,  Erhua CAO ,  Genqian LI ,  Robert F. ZUK

IPC: G01N35/00 ,  G01N33/543 ,  B01L3/00 ,  G01N35/02 ,  G01N35/04

Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.

公开(公告)号：US20160370363A1

公开(公告)日：2016-12-22

申请号：US15256319

申请日：2016-09-02

Applicant: Access Medical Systems, LTD.

Inventor： Hong TAN ,  Robert F. ZUK ,  Yushan TAN ,  Erhua CAO ,  Min XIA ,  Jun CHEN

IPC: G01N33/543 ,  G01N21/64

CPC classification number: G01N33/54366 ,  C08B37/006 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/54373 ,  G01N2021/6439 ,  G01N2201/06113

Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels.

Abstract translation: 本发明涉及一种用于在荧光测定中测量荧光信号的检测系统。 该系统包括具有与荧光标签结合的小感测表面的探针，以及安装在基底的感测表面的近侧的光源和检测器。 本发明还涉及使用具有小表面积（≤5mm）和具有多个结合分子和多个荧光标记的高分子量聚合物（≥1M）的探针尖端来检测液体样品中的分析物的方法。 通过横向流动反应溶液并在反应容器中上下移动探针尖端来加速结合反应。 本发明进一步涉及包含具有多个结合分子和多个荧光标记的交联FICOLL®分子的荧光标记组合物。

公开(公告)号：US20130295591A1

公开(公告)日：2013-11-07

申请号：US13936047

申请日：2013-07-05

Applicant: Access Medical Systems, LTD.

Inventor： Hong TAN ,  Ming XIA ,  Yushan TAN ,  Jun CHEN ,  Erhua CAO ,  Genqian LI ,  Robert F. ZUK

IPC: G01N33/543

CPC classification number: B01L3/52 ,  B01L3/502 ,  B01L3/527 ,  B01L2300/042 ,  B01L2300/045 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/54366 ,  G01N35/026 ,  G01N2035/0436

Abstract: This invention relates to a cartridge for an immunoassay test. The cartridge comprises (a) a probe well comprising a probe and a cap, the cap being in a closed position to enclose the probe in the probe well, wherein the probe has a bottom tip coated with analyte-binding molecules; (b) a sample well to receive a sample; (c) one or more reagent wells; (d) a plurality of wash wells each containing a first aqueous solution; and (e) a measurement well having a light transmissive bottom, the measurement well containing a second aqueous solution; wherein the openings of the sample well, reagent well, measurement well and wash wells are sealed. The present invention also relates to an apparatus for loading and releasing a probe. The apparatus comprises a push pin and a groove to load and transfer the probe to a plurality of locations, such as different wells in the above-mentioned cartridge, to conduct the immunoassay test.

Abstract translation: 本发明涉及用于免疫测定试验的药筒。 所述筒包括（a）包括探针和帽的探针孔，所述盖处于闭合位置以将所述探针包围在探针中，其中所述探针具有涂覆有分析物结合分子的底部尖端; （b）样品孔以接收样品; （c）一个或多个试剂孔; （d）多个洗涤孔，每个洗涤孔含有第一水溶液; 和（e）具有透光底部的测量井，所述测量井含有第二水溶液; 其中样品阱，试剂阱，测量井和洗涤井的开口被密封。 本发明还涉及一种用于装载和释放探针的装置。 该装置包括推针和凹槽，以将探针加载并转移到多个位置，例如上述药筒中的不同的孔，以进行免疫测定。

公开(公告)号：US20130052081A1

公开(公告)日：2013-02-28

申请号：US13659576

申请日：2012-10-24

Applicant: Access Medical Systems, LTD.

Inventor： Hong TAN ,  Robert F. ZUK ,  Yushan TAN ,  Erhua CAO ,  Min XIA ,  Jun CHEN

IPC: G01N33/53

CPC classification number: G01N33/54366 ,  C08B37/006 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/54373 ,  G01N2021/6439 ,  G01N2201/06113

Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels.

Abstract translation: 本发明涉及一种用于在荧光测定中测量荧光信号的检测系统。 该系统包括具有与荧光标签结合的小感测表面的探针，以及安装在基底的感测表面的近侧的光源和检测器。 本发明还涉及一种使用具有小表面积（＆NlE; 5mm）的探针尖端和具有多个结合分子和多个荧光标记的高分子量聚合物（≥1MD）来检测液体样品中的分析物的方法。 通过横向流动反应溶液并在反应容器中上下移动探针尖端来加速结合反应。 本发明进一步涉及包含具有多个结合分子和多个荧光标记的交联FICOLL®分子的荧光标记组合物。

公开(公告)号：US20190285658A1

公开(公告)日：2019-09-19

申请号：US16421015

申请日：2019-05-23

Applicant: Access Medical Systems, LTD.

Inventor： Hong TAN ,  Ming XIA ,  Yushan TAN ,  Jun CHEN ,  Erhua CAO ,  Genqian LI ,  Robert F. ZUK

IPC: G01N35/00 ,  G01N33/543 ,  B01L3/00

Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.

公开(公告)号：US20170043338A1

公开(公告)日：2017-02-16

申请号：US15293173

申请日：2016-10-13

Applicant: Access Medical Systems, LTD.

Inventor： Hong TAN ,  Ming XIA ,  Yushan TAN ,  Jun CHEN ,  Erhua CAO ,  Genqian LI ,  Robert F. ZUK

IPC: B01L3/00 ,  G01N35/00 ,  G01N33/74

CPC classification number: G01N35/00 ,  B01L3/502 ,  B01L3/527 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/045 ,  G01N33/54353 ,  G01N33/54366 ,  G01N35/026 ,  G01N2035/0436

Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.

Abstract translation: 本发明涉及进行免疫测定试验的装置。 所述装置包括：槽单元，具有沿着垂直方向具有沿着垂直方向保持探针的杆状部分的垂直方向的槽;以及推动销，其构造成沿水平方向移动，所述推动销能够驻留在 第一职位和第二职位。 当推销位于第一位置时，推针的尖端能够将探针的杆状部分压靠在凹槽上。 当推销位于第二位置时，推针的尖端与槽之间的距离大于探针的棒状部分的直径。