公开(公告)号：US20240344113A1

公开(公告)日：2024-10-17

申请号：US18750680

申请日：2024-06-21

Applicant: GEN-PROBE INCORPORATED

Inventor： David Aaron BUSE ,  David OPALSKY ,  Jason F. RHUBOTTOM ,  Norbert D. HAGEN ,  Jennifer TIDD

IPC: C12Q1/6806 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686 ,  G01N35/04

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: A method for performing an amplification reaction comprises the automated steps of combining a fluid sample together with one or more amplification reaction reagents in a reaction receptacle using a first automated pipettor, thereby forming a reaction mixture, transporting the reaction receptacle to a first, predetermined location of a centrifuge, subjecting the reaction mixture to centrifugation, after subjecting the reaction mixture to centrifugation, removing the reaction receptacle from a second, predetermined location of the centrifuge different from the first predetermined location and placing the reaction receptacle in a thermocycler, and in the thermocycler, subjecting the reaction mixture to one or more temperature cycles.

公开(公告)号：US20240302395A1

公开(公告)日：2024-09-12

申请号：US18410827

申请日：2024-01-11

Applicant: Genentech, Inc.

Inventor： Nicholas RUMMEL ,  James DVORNICKY

IPC: G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N35/026 ,  G01N35/1011 ,  G01N35/1067 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: Provided herein are systems, devices and methods for retaining chromatographic minicolumns in a holding fixture. A retaining apparatus may be provided with a pair of laterally spaced apart upright supports and a horizontal beam spanning between the upright supports to hold them in the laterally spaced apart relationship. The apparatus may be configured to contact a holder plate only along peripheral edges of the holder plate. The apparatus may be configured to slide along the holder plate after the minicolumns have been inserted therein, thereby retaining the minicolumns in the holder plate but allowing access to the minicolumns through vertical holes in the horizontal beam.

公开(公告)号：US11746373B2

公开(公告)日：2023-09-05

申请号：US17847096

申请日：2022-06-22

Applicant: GEN-PROBE INCORPORATED

Inventor： Byron J. Knight ,  David A. Buse ,  Norbert D. Hagen ,  David Opalsky ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: B01L3/00 ,  B01L7/00 ,  G01N35/04 ,  C12Q1/6806 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: A cap and a processing vial configured for interlocking engagement. The processing vial includes a locking collar surrounding an open upper end of the processing vial with lateral through holes formed through the locking collar. The vial also includes a latch hook located above each through hole. The cap includes a latch collar extending about a lower portion of the cap, where the latch collar is configured to snap in beneath the latch hooks of the processing vial when the lower portion of the cap is inserted into the open upper end of the processing vial to lock the cap to the processing vial.

公开(公告)号：US09915648B2

公开(公告)日：2018-03-13

申请号：US13817259

申请日：2011-08-05

Applicant: Alfred Janetzko ,  Wilhelm Sänger ,  Cyril E. Geacintov

Inventor： Alfred Janetzko ,  Wilhelm Sänger ,  Cyril E. Geacintov

IPC: G01N33/53 ,  G01N35/10 ,  G01N35/04

CPC classification number: G01N33/53 ,  G01N35/10 ,  G01N2035/0436

Abstract: The invention relates to a method of analysing a sample, comprising the analysis of clinical-chemical parameters and the analysis of immunodiagnostic parameters in a fully automatic analysis apparatus, wherein the analysis apparatus comprises a pipetting apparatus, at least one holder for a reagent cartridge containing the components necessary for carrying out the analysis, a holding apparatus for a measurement cell, at least one measurement cell, with each reagent cartridge being associated with a measurement cell, a holding apparatus for a sample container containing sample, and a photometric or spectrometric measurement device. On the basis of a sample it is possible here for a plurality of different clinical-chemical and/or immunodiagnostic parameters to be determined, to which end a dedicated reagent cartridge is inserted into a holding apparatus of the analysis apparatus for each clinical-chemical or immunodiagnostic parameter to be determined.

公开(公告)号：US09732374B2

公开(公告)日：2017-08-15

申请号：US14213900

申请日：2014-03-14

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Opalsky ,  Jason F. Rhubottom ,  Norbert D. Hagen ,  Jennifer L. Tidd

IPC: C12Q1/68 ,  B01L3/00 ,  G01N35/04 ,  B01L7/00

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/527 ,  B01L3/565 ,  B01L7/5255 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  C12Q1/686 ,  G01N35/04 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset.

公开(公告)号：US09731847B2

公开(公告)日：2017-08-15

申请号：US13710857

申请日：2012-12-11

Applicant: Ortho-Clinical Diagnostics, Inc.

Inventor： Jens H. Jorgensen ,  Joseph Wycallis

IPC: B01L3/00 ,  B65B5/06 ,  G01N35/04

CPC classification number: B65B5/06 ,  B01L3/545 ,  G01N2035/0436 ,  G01N2035/0439 ,  G01N2035/0493

Abstract: An immunodiagnostic test method includes holding a selection of immunological test elements or consumables in one or more containers attached to or positioned in the analyzer and providing random access to any test element therein. The container can hold multiple types of test elements in compartments or slots. Through sensing of a test element position in its slot, the detection mechanism of the invention provides for random access to multiple types of test elements in any sleeve and within a single sleeve, and provides efficient inventory control. The method increases the number of test element types that may be loaded onto an analyzer and maintains fast determination of inventory.

公开(公告)号：US20170146515A1

公开(公告)日：2017-05-25

申请号：US15425253

申请日：2017-02-06

Applicant: POCARED Diagnostics LTD.

Inventor： Gal Ingber ,  William G. Atterbury ,  Russell H. Barnes ,  Douglas E. Boyd ,  Joseph D. Dennis ,  Jonathan Gurfinkel ,  Dave Holley ,  Steven E. Huckaby ,  Thomas A. Klausing ,  John S. Laudo ,  Kevin Sadeski ,  Jason A. Schaefer ,  K. Bryan Scott ,  Carol Stillman ,  Sherwood Talbert ,  John Tallarico

IPC: G01N33/493 ,  C12Q1/04 ,  G01N35/04 ,  G01N21/03 ,  G01N35/02

CPC classification number: G01N33/493 ,  C12Q1/04 ,  G01N21/0303 ,  G01N35/025 ,  G01N35/04 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0458 ,  G01N2201/0415

Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

公开(公告)号：US09519000B2

公开(公告)日：2016-12-13

申请号：US13747945

申请日：2013-01-23

Applicant: Beckman Coulter, Inc.

Inventor： Brian D. Wilson ,  Alan N. Johnson ,  Charles S. Kraihanzel ,  Joshua D. Wiltsie

IPC: B01L3/00 ,  G01N35/04 ,  G01N35/10 ,  G01N35/00 ,  C12P19/34 ,  G05B13/02 ,  B01L7/00 ,  C12Q3/00 ,  G01F23/24 ,  G01F23/26 ,  G06F19/10 ,  C12M1/34 ,  C12Q1/68 ,  G01N1/38 ,  G01N1/31 ,  B01L3/02

CPC classification number: G01N35/04 ,  B01L3/021 ,  B01L3/0275 ,  B01L3/50825 ,  B01L3/5085 ,  B01L3/50851 ,  B01L3/52 ,  B01L3/545 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/024 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/045 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0851 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/043 ,  C12M41/12 ,  C12P19/34 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q3/00 ,  G01F23/24 ,  G01F23/26 ,  G01N1/31 ,  G01N1/38 ,  G01N35/00732 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/1002 ,  G01N35/1011 ,  G01N35/1016 ,  G01N35/1081 ,  G01N2035/00435 ,  G01N2035/00752 ,  G01N2035/00851 ,  G01N2035/0413 ,  G01N2035/0415 ,  G01N2035/0436 ,  G01N2035/0465 ,  G01N2035/0475 ,  G01N2035/1013 ,  G01N2035/1025 ,  G01N2035/1048 ,  G01N2035/1051 ,  G01N2035/1076 ,  G05B13/02 ,  G05B13/0205 ,  G06F19/10 ,  Y10T436/113332

Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

Abstract translation: 公开了用于处理和分析样品的系统和方法。 该系统可以使用可在不同处理位置处理的测定盒来处理样品，例如生物流体。 在某些情况下，该系统可用于PCR处理。 不同的处理位置可以包括可以准备样品的准备位置和可以分析样品的分析位置。 为了帮助准备样品，系统还可以包括可以包括加工车道的多个处理站。 在样品分析期间，在某些情况下，可以使用热循环仪模块和适当的光学检测系统来检测样品中某些核酸序列的存在或不存在。 该系统可用于准确快速地处理样品。

公开(公告)号：US20160214114A1

公开(公告)日：2016-07-28

申请号：US15089812

申请日：2016-04-04

Applicant: Access Medical Systems, LTD.

Inventor： Hong TAN ,  Yongli REN ,  Ming XIA ,  Genqian LI

IPC: B01L9/00 ,  G01N33/53 ,  G01N33/536 ,  G01N35/00

CPC classification number: G01N35/00029 ,  B01L3/50855 ,  B01L9/00 ,  B01L9/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0809 ,  G01N33/5304 ,  G01N33/536 ,  G01N2035/00148 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.

Abstract translation: 本发明涉及一种用于进行自动生化测试的盒组件托盘，例如免疫测定。 托盘包括基座构件，铰链框架和锁定机构。 基座构件包括在基座构件内的多个槽。 多个狭槽中的每一个都将接收测试盒。 铰链框架联接到基座构件。 铰链框架能够旋转到打开位置或关闭位置。 铰链框架包括水平推杆，其构造成当铰链框架处于关闭位置时施加向下的力来测试容纳在多个槽中的盒。 当铰链框架旋转到关闭位置时，锁定机构将铰链框架锁定在关闭位置。

公开(公告)号：US09335339B2

公开(公告)日：2016-05-10

申请号：US13376007

申请日：2010-06-04

Applicant: Hideji Tajima

Inventor： Hideji Tajima

IPC: G01N21/00 ,  G01N35/02 ,  G01N35/04

CPC classification number: G01N35/026 ,  G01N2035/0436

Abstract: The present invention relates to a specimen testing device and method thereof, and it is an object of the present invention to provide a compact and reliable specimen testing device and method thereof. The specimen testing device includes one, two or more test cartridge containers which comprise a plurality of accommodation parts which accommodate or can accommodate a specimen and one, two or more reagent solutions or testing tools used for testing the specimen, and which visibly display specimen information for identifying or managing the specimen and test information showing test content; an automatic testing unit which is attached with or supports the testing tools and which causes a reaction of the specimen and the reagent solution accommodated in the test cartridge containers to obtain a predetermined optical state; an optical measurement unit which measures the optical state obtained by the automatic testing unit; and a digital camera which captures an image of content including the specimen information and the test information and displayed on the one, two or more test cartridge containers to obtain image data.

Abstract translation: 检体检测装置及其方法技术领域本发明涉及试样检测装置及其方法，其目的在于提供一种紧凑可靠的标本试验装置及其方法。 样本测试装置包括一个，两个或更多个测试盒容器，其包括容纳或可容纳样本的多个容纳部分和用于测试样本的一个，两个或更多个试剂溶液或测试工具，并且可视地显示样本信息 用于识别或管理标本，并显示测试内容的测试信息; 自动测试单元，其附接或支撑测试工具，并且引起样品和容纳在测试盒容器中的试剂溶液的反应以获得预定的光学状态; 光学测量单元，其测量由所述自动测试单元获得的光学状态; 以及数字照相机，其捕获包括样本信息和测试信息的内容的图像，并显示在一个，两个或更多个测试盒容器上以获得图像数据。