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公开(公告)号：US11235031B2
公开(公告)日：2022-02-01
申请号：US16564739
申请日：2019-09-09
IPC分类号： A61K38/18
摘要： The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
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2.发明申请公开(公告)号：US20180303904A1
公开(公告)日：2018-10-25
申请号：US15957122
申请日：2018-04-19
IPC分类号： A61K38/18 , A61K9/00 , A61K31/5513
CPC分类号： A61K38/1883 , A61K9/0019 , A61K31/5513 , A61K38/1808
摘要： The invention relates to treatment and prevention of heart failure in a mammal. The invention provides a dosing regimen whereby the therapeutic benefits conferred by administration of peptide comprising an epidermal growth factor-like domain, e.g., a neuregulin such as glial growth factor 2 (GGF2) or a functional fragment thereof, are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
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公开(公告)号：US20180055909A1
公开(公告)日：2018-03-01
申请号：US15658967
申请日：2017-07-25
发明人： Haesun Kim , Anthony O. Caggiano
摘要： The present invention relates to administering glial growth factor 2 (GGF2) to a patient in need thereof, to achieve serum levels of GGF2 within a desired therapeutic window determined based on the disease or disorder afflicting the patient. In a particular embodiment, the patient is suffering from a disease or disorder associated with reduced levels of myelination and the GGF2 is administered to promote myelination in the patient.
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公开(公告)号：US09839679B2
公开(公告)日：2017-12-12
申请号：US14191407
申请日：2014-02-26
摘要： A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.
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公开(公告)号：US09834764B2
公开(公告)日：2017-12-05
申请号：US15216039
申请日：2016-07-21
IPC分类号： A61K38/00 , A61K38/46 , C12N9/26 , C12N9/88 , C12N9/24 , C12N9/14 , C12P21/06 , C12P19/34 , C07H21/04 , C07K1/00 , A61K38/51
CPC分类号： C12N9/88 , A61K38/00 , A61K38/51 , C12Y402/02004
摘要： One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
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公开(公告)号：US20160346353A1
公开(公告)日：2016-12-01
申请号：US14978287
申请日：2015-12-22
发明人： Anthony O. Caggiano , Anthony J. Bella , Anindita Ganguly , Jennifer Iaci , Tom Parry , Raymond Warren Colburn
IPC分类号： A61K38/18
CPC分类号： A61K38/1883
摘要： The disclosure provides compositions and methods for preventing, ameliorating a sign or symptom of, or treating peripheral nerve injury.
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公开(公告)号：US09329171B2
公开(公告)日：2016-05-03
申请号：US14153695
申请日：2014-01-13
发明人： Xinhua Yan , Anthony O. Caggiano
CPC分类号： A61K38/1883 , A61K49/0004 , G01N33/5061 , G01N33/5091 , G01N33/6887 , G01N2333/47 , G01N2333/4712 , G01N2800/32 , G01N2800/324
摘要： The present invention relates to a method for detecting heart damage in a patient. The invention also relates to methods for treatment of patients identified as having heart damage. The invention further pertains to methods for evaluating the efficacy of an ongoing therapeutic regimen designated to treat a damaged heart in a patient.
摘要翻译： 本发明涉及一种用于检测患者心脏损伤的方法。 本发明还涉及用于治疗被鉴定为具有心脏损伤的患者的方法。 本发明还涉及用于评估指定用于治疗患者的受损心脏的正在进行的治疗方案的功效的方法。
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8.发明申请METHODS FOR TREATING SENSORIMOTOR IMPAIRMENTS ASSOCIATED WITH CERTAIN TYPES OF STROKE USING AMINOPYRIDINES 审中-公开治疗与某些类型的使用氨基吡啶类型的传感器损伤相关的方法公开(公告)号：US20160058743A1
公开(公告)日：2016-03-03
申请号：US14784279
申请日：2014-04-14
IPC分类号： A61K31/4409 , A61K9/20
CPC分类号： A61K31/4409 , A61K9/20 , A61P9/10 , A61P25/00
摘要： Disclosed herein are methods and compositions related to therapeutic use of aminopyridines in patients with stroke-related impairments, in particular, in patients with sensorimotor impairments resulting from certain types of stroke.
摘要翻译： 本文公开了与中风相关损伤患者，特别是在由某些类型的中风引起的感觉运动障碍的患者中治疗性使用氨基吡啶有关的方法和组合物。
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9.发明授权Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure 有权治疗剂量的神经调节蛋白或其后续剂量用于治疗或预防心力衰竭公开(公告)号：US09198951B2
公开(公告)日：2015-12-01
申请号：US13904654
申请日：2013-05-29
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： A61K38/1883 , A61K38/18
摘要： The invention relates to treatment of heart failure in a mammal. Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects.
摘要翻译： 本发明涉及哺乳动物心脏衰竭的治疗。 因此，本发明涉及建立一种给药方案，其中通过施用神经胶质细胞如神经胶质细胞生长因子2（GGF2）或其子序列来维持和/或增强神经调节蛋白所赋予的治疗益处，同时最小化任何潜在的副作用。
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公开(公告)号：US10258667B2
公开(公告)日：2019-04-16
申请号：US15674053
申请日：2017-08-10
发明人： Xinhua Yan , Anthony O. Caggiano
摘要： The present mention relates to a method for detecting heart damage in a patient. The invention also relates to methods for treatment of patients identified as having heart damage. The invention further pertains to methods for evaluating the efficacy of an ongoing therapeutic regimen designated to treat a damaged heart in a patient.
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