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公开(公告)号：US20140128453A1
公开(公告)日：2014-05-08
申请号：US14114187
申请日：2012-04-27
申请人： Adam Mullick , Rosanne M. Crooke , Mark J. Graham , Kenneth W. Dobie , Thomas A. Bell, III , Richard Lee
发明人： Adam Mullick , Rosanne M. Crooke , Mark J. Graham , Kenneth W. Dobie , Thomas A. Bell, III , Richard Lee
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/351 , A61K2300/00
摘要： Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.
摘要翻译： 本文提供了用于在动物中降低ApoCIII mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于增加HDL水平和/或改善动物体内TG与HDL的比例以及降低血浆脂质和血浆葡萄糖的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢紊乱或其症状中的任何一种或多种。
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公开(公告)号：US09157082B2
公开(公告)日：2015-10-13
申请号：US14114187
申请日：2012-04-27
IPC分类号： C12N15/113 , A61K31/7088 , A61K45/06 , A61K31/713
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/351 , A61K2300/00
摘要： Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.
摘要翻译： 本文提供了用于在动物中降低ApoCIII mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于增加HDL水平和/或改善动物体内TG与HDL的比例以及降低血浆脂质和血浆葡萄糖的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢紊乱或其症状中的任何一种或多种。
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公开(公告)号：US20130023579A1
公开(公告)日：2013-01-24
申请号：US13520997
申请日：2011-01-07
IPC分类号： A61K31/7088 , A61P3/00 , C07H21/00 , A61P9/00
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , C12N2310/3521
摘要： Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
摘要翻译： 本文提供了用于减少动物中ANGPTL3 mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于降低动物体内血浆脂质，血浆葡萄糖和动脉粥样硬化斑块的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢疾病或其症状中的任何一种或多种。
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公开(公告)号：US20110060030A1
公开(公告)日：2011-03-10
申请号：US12781479
申请日：2010-05-17
IPC分类号： A61K31/7088 , C07H21/00 , C12N5/071 , C12Q1/68 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/10 , A61P3/00 , A61P9/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和诊断和治疗与载脂蛋白C-III表达相关的疾病的方法
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公开(公告)号：US07750141B2
公开(公告)日：2010-07-06
申请号：US10553722
申请日：2004-04-15
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。
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公开(公告)号：US08530439B2
公开(公告)日：2013-09-10
申请号：US12781479
申请日：2010-05-17
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
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公开(公告)号：US07598227B2
公开(公告)日：2009-10-06
申请号：US10418780
申请日：2003-04-16
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。
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公开(公告)号：US20130053430A1
公开(公告)日：2013-02-28
申请号：US13639837
申请日：2011-04-07
IPC分类号： A61K31/7125 , A61K31/7088 , A61K31/712 , A61K31/7115 , A61P3/00 , A61P3/06 , A61P9/00 , A61P9/12 , A61P3/04 , A61P3/10 , C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/322 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of a CETP mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or HDL activity and reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
摘要翻译： 本文提供了用于减少动物中CETP mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供用于增加动物体内HDL水平和/或HDL活性和降低血浆脂质，血浆葡萄糖和动脉粥样硬化斑块的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢疾病或其症状中的任何一种或多种。
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公开(公告)号：US08653047B2
公开(公告)日：2014-02-18
申请号：US13520997
申请日：2011-01-07
申请人： Rosanne M. Crooke , Mark J. Graham , Richard Lee
发明人： Rosanne M. Crooke , Mark J. Graham , Richard Lee
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , C12N2310/3521
摘要： Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
摘要翻译： 本文提供了用于减少动物中ANGPTL3 mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于降低动物体内血浆脂质，血浆葡萄糖和动脉粥样硬化斑块的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢疾病或其症状中的任何一种或多种。
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公开(公告)号：US20120077866A1
公开(公告)日：2012-03-29
申请号：US13309835
申请日：2011-12-02
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
IPC分类号： A61K31/7088 , C12N5/07 , A61P31/00 , A61P9/10 , A61P35/00 , A61P9/00 , A61P13/12 , A61P19/02 , A61P3/04 , A61P29/00 , C07H21/00 , A61P17/02
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含靶向编码C反应蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C反应蛋白表达和治疗与C反应蛋白表达相关的疾病的方法。
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