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1.发明授权Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use 失效作为GalR1的激动剂的双磺酰胺化合物，组合物和使用方法公开(公告)号：US07582673B2
公开(公告)日：2009-09-01
申请号：US11255000
申请日：2005-10-20
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Suvi Simila , Tan Ren
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Suvi Simila , Tan Ren
IPC分类号： A61K31/381 , A61K31/18 , C07D333/66 , C07C311/21
CPC分类号： C07D213/42 , C07C311/29 , C07D233/54 , C07D307/82 , C07D333/34 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/12 , C07D495/04
摘要： Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.
摘要翻译： 本发明的实施方案提供作为GalR1的激动剂的双磺酰胺化合物。 本发明还提供了包含作为GalR1的激动剂的双磺酰胺化合物的组合物，以及这些化合物和组合物的使用方法。
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2.发明申请Bissulfonamide Compounds As Agonists Of GalR1, Compositions, And Methods Of Use 审中-公开双磺酰胺化合物作为GalR1的激动剂，组合物和使用方法公开(公告)号：US20090247536A1
公开(公告)日：2009-10-01
申请号：US12483429
申请日：2009-06-12
申请人： Adnan M.M. Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Suvi Simila , Tan Ren
发明人： Adnan M.M. Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert C. Andrews , Stephen Davis , Suvi Simila , Tan Ren
IPC分类号： A61K31/497 , A61K31/381 , A61K31/4164 , A61P25/00
CPC分类号： C07D213/42 , C07C311/29 , C07D233/54 , C07D307/82 , C07D333/34 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/12 , C07D495/04
摘要： Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.
摘要翻译： 本发明的实施方案提供作为GalR1的激动剂的双磺酰胺化合物。 本发明还提供了包含作为GalR1的激动剂的双磺酰胺化合物的组合物，以及这些化合物和组合物的使用方法。
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公开(公告)号：US20060106089A1
公开(公告)日：2006-05-18
申请号：US11255000
申请日：2005-10-20
申请人： Adnan Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert Andrews , Stephen Davis , Suvi Simila , Tan Ren
发明人： Adnan Mjalli , Bapu Gaddam , Mohan Rao , Muralidhar Bondlela , Ramesh Gopalaswamy , Robert Andrews , Stephen Davis , Suvi Simila , Tan Ren
IPC分类号： A61K31/381 , C07D409/02 , A61K31/18 , C07C311/37
CPC分类号： C07D213/42 , C07C311/29 , C07D233/54 , C07D307/82 , C07D333/34 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/12 , C07D495/04
摘要： Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.
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![SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS](/abs-image/US/2012/04/26/US20120101093A1/abs.jpg.150x150.jpg)
4.发明申请SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS 审中-公开取代的咪唑并[1,2-A]吡啶衍生物，药物组合物和使用作为β-分泌酶抑制剂的方法公开(公告)号：US20120101093A1
公开(公告)日：2012-04-26
申请号：US13214762
申请日：2011-08-22
申请人： Adnan M. M. Mjalli , Anitha Hari , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Robert Carl Andrews , Rongyuan Xie , Tan Ren
发明人： Adnan M. M. Mjalli , Anitha Hari , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Robert Carl Andrews , Rongyuan Xie , Tan Ren
IPC分类号： A61K31/437 , A61K31/496 , A61K31/444 , A61K31/506 , A61P25/28 , A61K31/4545 , C07D471/04 , A61K31/5377
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention is directed to substituted imidazo[1,2-a]pyridine derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
摘要翻译： 本发明涉及取代的咪唑并[1,2-a]吡啶衍生物，其药学上可接受的盐，以及这些化合物或盐的互变异构体，其可抑制β-淀粉样蛋白前体蛋白切割酶（BACE），并且可以是 可用于治疗涉及BACE的疾病，例如阿尔茨海默病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及BACE的疾病中的用途。
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![Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors](/abs-image/US/2013/05/28/US08450354B2/abs.jpg.150x150.jpg)
5.发明授权Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as β-secretase inhibitors 失效取代的咪唑并[1,2-b]哒嗪衍生物，药物组合物和用作β-分泌酶抑制剂的方法公开(公告)号：US08450354B2
公开(公告)日：2013-05-28
申请号：US13052544
申请日：2011-03-21
申请人： Adnan M. M. Mjalli , Anitha Hari , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Mohan Rao , Raju Bore Gowda , Robert Carl Andrews , Rongyuan Xie , Soumya P. Sahoo , Tan Ren , William Kenneth Banner
发明人： Adnan M. M. Mjalli , Anitha Hari , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Mohan Rao , Raju Bore Gowda , Robert Carl Andrews , Rongyuan Xie , Soumya P. Sahoo , Tan Ren , William Kenneth Banner
IPC分类号： A01N43/50 , A61K31/415 , C07D403/02
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit β-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved.
摘要翻译： 本发明提供了取代的咪唑并[1,2-b]哒嗪衍生物，其药学上可接受的盐和任何前述的互变异构体，其中这些化合物抑制β-位淀粉样蛋白前体蛋白切割酶（BACE），其可能是有用的 用于治疗BACE所涉及的疾病，如阿尔茨海默病。 本发明还提供包含任何这些化合物的药物组合物以及这些化合物和组合物中任何一种用于治疗BACE所涉及的疾病，病症或病症的用途。
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6.发明授权Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors 失效取代的异喹啉衍生物，药物组合物和用作β-分泌酶抑制剂的方法公开(公告)号：US08350039B2
公开(公告)日：2013-01-08
申请号：US13214434
申请日：2011-08-22
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
IPC分类号： C07D217/26 , A61K31/472 , A61K31/4725 , A61P25/28
CPC分类号： C07D401/12 , C07D401/14
摘要： The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
摘要翻译： 本发明涉及取代的异喹啉衍生物，其药学上可接受的盐，以及此类化合物或盐的互变异构体，其可抑制β-淀粉样蛋白前体蛋白切割酶（BACE），并可用于治疗疾病，其中 BACE参与，如阿尔茨海默病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及BACE的疾病中的用途。
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7.发明申请SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS 失效取代的异喹啉衍生物，药物组合物和使用作为β-分泌酶抑制剂的方法公开(公告)号：US20120101125A1
公开(公告)日：2012-04-26
申请号：US13214434
申请日：2011-08-22
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
IPC分类号： A61K31/472 , A61K31/4725 , A61P25/28 , C07D217/26
CPC分类号： C07D401/12 , C07D401/14
摘要： The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
摘要翻译： 本发明涉及取代的异喹啉衍生物，其药学上可接受的盐，以及这些化合物或盐的互变异构体，其可抑制β-淀粉样蛋白前体蛋白切割酶（BACE），并可用于治疗疾病，其中 BACE参与，如阿尔茨海默病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及BACE的疾病中的用途。
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8.发明授权Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use 失效取代的氨基噻唑衍生物，药物组合物和使用方法公开(公告)号：US08563742B2
公开(公告)日：2013-10-22
申请号：US12547018
申请日：2009-08-25
IPC分类号： A61K31/427 , C07D417/12
CPC分类号： C07D417/14 , A61K31/425 , C07D417/12
摘要： Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译： 取代的氨基噻唑衍生物，其制备方法，包含取代的氨基噻唑的药物组合物，以及用于治疗人或动物疾病的方法。 该化合物可用作AgRP对黑皮质素受体的作用的抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体（包括肥胖相关病症）的调节有反应的疾病。
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9.发明申请Substituted Aminothiazole Derivatives, Pharmaceutical Compositions, And Methods Of Use 失效取代的氨基噻唑衍生物，药物组合物和使用方法公开(公告)号：US20100056587A1
公开(公告)日：2010-03-04
申请号：US12547018
申请日：2009-08-25
IPC分类号： A61K31/427 , C07D409/12 , C07D409/14
CPC分类号： C07D417/14 , A61K31/425 , C07D417/12
摘要： Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译： 取代的氨基噻唑衍生物，其制备方法，包含取代的氨基噻唑的药物组合物，以及用于治疗人或动物疾病的方法。 该化合物可用作AgRP对黑皮质素受体的作用的抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体（包括肥胖相关病症）的调节有反应的疾病。
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![SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS](/abs-image/US/2011/09/29/US20110237570A1/abs.jpg.150x150.jpg)
10.发明申请SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS 失效取代的咪唑并[1,2-B]吡啶衍生物，药物组合物和使用作为β-分泌酶抑制剂的方法公开(公告)号：US20110237570A1
公开(公告)日：2011-09-29
申请号：US13052544
申请日：2011-03-21
申请人： Adnan M.M. Mjalli , Anitha Hari , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Mohan Rao , Raju Bore Gowda , Robert Carl Andrews , Rongyuan Xie , Soumya P. Sahoo , Tan Ren , William Kenneth Banner
发明人： Adnan M.M. Mjalli , Anitha Hari , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Mohan Rao , Raju Bore Gowda , Robert Carl Andrews , Rongyuan Xie , Soumya P. Sahoo , Tan Ren , William Kenneth Banner
IPC分类号： A61K31/55 , C07D487/04 , A61K31/5025 , A61K31/5377 , A61P25/28 , A61P25/00 , A61P7/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit β-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved.
摘要翻译： 本发明提供了取代的咪唑并[1,2-b]哒嗪衍生物，其药学上可接受的盐和任何前述的互变异构体，其中这些化合物抑制β-淀粉样蛋白前体蛋白切割酶（BACE），其可以是 可用于治疗涉及BACE的疾病，例如阿尔茨海默病。 本发明还提供包含任何这些化合物的药物组合物以及这些化合物和组合物中任何一种用于治疗BACE所涉及的疾病，病症或病症的用途。
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