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1.发明申请公开(公告)号：US20080058340A1
公开(公告)日：2008-03-06
申请号：US11830733
申请日：2007-07-30
申请人： Andreas Maderna , Jean-Michel Vernier , Dinesh Barawkar , Varaprasad Chamakura , Hassan El Abdellaoui , Zhi Hong
发明人： Andreas Maderna , Jean-Michel Vernier , Dinesh Barawkar , Varaprasad Chamakura , Hassan El Abdellaoui , Zhi Hong
IPC分类号： A61K31/18 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/495 , A61P29/00 , A61P3/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P9/00 , C07C311/08 , C07C311/09 , C07C311/14 , C07C311/21 , C07C311/29 , C07D207/36 , C07D231/18 , C07D233/84 , C07D261/10 , C07D277/36 , C07D277/54 , C07D295/13 , C07D307/64 , C07D333/34 , C07D417/04
CPC分类号： C07D417/04 , A61K31/18 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/496 , A61K45/06 , C07B2200/07 , C07C311/08 , C07C311/09 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/28 , C07C311/29 , C07C311/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/36 , C07D211/54 , C07D213/38 , C07D213/42 , C07D231/12 , C07D231/18 , C07D233/84 , C07D261/10 , C07D277/36 , C07D277/54 , C07D285/04 , C07D295/088 , C07D295/13 , C07D307/64 , C07D333/34
摘要： This invention concerns N-(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.
摘要翻译： 本发明涉及作为MEK抑制剂的N-（2-芳基氨基）芳基磺酰胺，可用于治疗癌症和其它过度增生性疾病。
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![SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS](/abs-image/US/2012/04/26/US20120101093A1/abs.jpg.150x150.jpg)
2.发明申请SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS 审中-公开取代的咪唑并[1,2-A]吡啶衍生物，药物组合物和使用作为β-分泌酶抑制剂的方法公开(公告)号：US20120101093A1
公开(公告)日：2012-04-26
申请号：US13214762
申请日：2011-08-22
申请人： Adnan M. M. Mjalli , Anitha Hari , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Robert Carl Andrews , Rongyuan Xie , Tan Ren
发明人： Adnan M. M. Mjalli , Anitha Hari , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Robert Carl Andrews , Rongyuan Xie , Tan Ren
IPC分类号： A61K31/437 , A61K31/496 , A61K31/444 , A61K31/506 , A61P25/28 , A61K31/4545 , C07D471/04 , A61K31/5377
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention is directed to substituted imidazo[1,2-a]pyridine derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
摘要翻译： 本发明涉及取代的咪唑并[1,2-a]吡啶衍生物，其药学上可接受的盐，以及这些化合物或盐的互变异构体，其可抑制β-淀粉样蛋白前体蛋白切割酶（BACE），并且可以是 可用于治疗涉及BACE的疾病，例如阿尔茨海默病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及BACE的疾病中的用途。
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公开(公告)号：US08101799B2
公开(公告)日：2012-01-24
申请号：US11830733
申请日：2007-07-30
申请人： Andreas Maderna , Jean-Michel Vernier , Dinesh Barawkar , Varaprasad Chamakura , Hassan El Abdellaoui , Zhi Hong
发明人： Andreas Maderna , Jean-Michel Vernier , Dinesh Barawkar , Varaprasad Chamakura , Hassan El Abdellaoui , Zhi Hong
IPC分类号： C07C307/00 , A61K31/18
CPC分类号： C07D417/04 , A61K31/18 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/496 , A61K45/06 , C07B2200/07 , C07C311/08 , C07C311/09 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/28 , C07C311/29 , C07C311/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/36 , C07D211/54 , C07D213/38 , C07D213/42 , C07D231/12 , C07D231/18 , C07D233/84 , C07D261/10 , C07D277/36 , C07D277/54 , C07D285/04 , C07D295/088 , C07D295/13 , C07D307/64 , C07D333/34
摘要： This invention concerns N—(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.
摘要翻译： 本发明涉及作为MEK抑制剂的N-（2-芳基氨基）芳基磺酰胺，可用于治疗癌症和其它过度增生性疾病。
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公开(公告)号：US07759518B2
公开(公告)日：2010-07-20
申请号：US12323279
申请日：2008-11-25
申请人： Andreas Maderna , Jean-Michel Vernier , Dinesh Barawkar , Varaprasad Chamakura , Hassan el Abdellaoui , Zhi Hong
发明人： Andreas Maderna , Jean-Michel Vernier , Dinesh Barawkar , Varaprasad Chamakura , Hassan el Abdellaoui , Zhi Hong
IPC分类号： C07C307/06 , A61K31/63
CPC分类号： C07D417/04 , A61K31/18 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/496 , A61K45/06 , C07B2200/07 , C07C311/08 , C07C311/09 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/28 , C07C311/29 , C07C311/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/36 , C07D211/54 , C07D213/38 , C07D213/42 , C07D231/12 , C07D231/18 , C07D233/84 , C07D261/10 , C07D277/36 , C07D277/54 , C07D285/04 , C07D295/088 , C07D295/13 , C07D307/64 , C07D333/34
摘要： This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.
摘要翻译： 本发明涉及作为MEK抑制剂的N-（2-芳基氨基）芳基磺酰胺，可用于治疗癌症和其它过度增生性疾病。
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5.发明申请公开(公告)号：US20090082457A1
公开(公告)日：2009-03-26
申请号：US12323279
申请日：2008-11-25
申请人： Andreas MADERNA , Jean-Michel VERNIER , Dinesh BARAWKAR , Varaprasad CHAMAKURA , Hassan EL ABDELLAOUI , Zhi HONG
发明人： Andreas MADERNA , Jean-Michel VERNIER , Dinesh BARAWKAR , Varaprasad CHAMAKURA , Hassan EL ABDELLAOUI , Zhi HONG
IPC分类号： C07C311/14 , A61K31/18
CPC分类号： C07D417/04 , A61K31/18 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/496 , A61K45/06 , C07B2200/07 , C07C311/08 , C07C311/09 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/28 , C07C311/29 , C07C311/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D207/36 , C07D211/54 , C07D213/38 , C07D213/42 , C07D231/12 , C07D231/18 , C07D233/84 , C07D261/10 , C07D277/36 , C07D277/54 , C07D285/04 , C07D295/088 , C07D295/13 , C07D307/64 , C07D333/34
摘要： This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.
摘要翻译： 本发明涉及作为MEK抑制剂的N-（2-芳基氨基）芳基磺酰胺，可用于治疗癌症和其它过度增生性疾病。
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6.发明授权Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors 失效取代的异喹啉衍生物，药物组合物和用作β-分泌酶抑制剂的方法公开(公告)号：US08350039B2
公开(公告)日：2013-01-08
申请号：US13214434
申请日：2011-08-22
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
IPC分类号： C07D217/26 , A61K31/472 , A61K31/4725 , A61P25/28
CPC分类号： C07D401/12 , C07D401/14
摘要： The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
摘要翻译： 本发明涉及取代的异喹啉衍生物，其药学上可接受的盐，以及此类化合物或盐的互变异构体，其可抑制β-淀粉样蛋白前体蛋白切割酶（BACE），并可用于治疗疾病，其中 BACE参与，如阿尔茨海默病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及BACE的疾病中的用途。
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7.发明申请SUBSTITUTED ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS BETA-SECRETASE INHIBITORS 失效取代的异喹啉衍生物，药物组合物和使用作为β-分泌酶抑制剂的方法公开(公告)号：US20120101125A1
公开(公告)日：2012-04-26
申请号：US13214434
申请日：2011-08-22
申请人： Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
发明人： Adnan M. M. Mjalli , Bapu Gaddam , Devi Reddy Gohimukkula , Dharma Rao Polisetti , Hassan El Abdellaoui , Mohan Rao , Pingzhen Wang , Robert Carl Andrews , Rongyuan Xie , Tan Ren
IPC分类号： A61K31/472 , A61K31/4725 , A61P25/28 , C07D217/26
CPC分类号： C07D401/12 , C07D401/14
摘要： The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.
摘要翻译： 本发明涉及取代的异喹啉衍生物，其药学上可接受的盐，以及这些化合物或盐的互变异构体，其可抑制β-淀粉样蛋白前体蛋白切割酶（BACE），并可用于治疗疾病，其中 BACE参与，如阿尔茨海默病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及BACE的疾病中的用途。
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公开(公告)号：US07652047B2
公开(公告)日：2010-01-26
申请号：US12171844
申请日：2008-07-11
申请人： Hassan El Abdellaoui , Robert Tam , Huanming Chen , Varaprasad Chamakura , Dinesh Barawkar , Andreas Maderna , Zhi Hong , Stanley Lang
发明人： Hassan El Abdellaoui , Robert Tam , Huanming Chen , Varaprasad Chamakura , Dinesh Barawkar , Andreas Maderna , Zhi Hong , Stanley Lang
IPC分类号： A61K31/425 , A61K31/427 , A61K31/5377 , A61K31/506 , A61K31/4439 , A61K31/496
CPC分类号： C07D417/14 , C07D275/03 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones.
摘要翻译： 本发明涉及抑制MEK并具有抗肿瘤剂活性的化合物。 这些化合物包括N-取代-3-羟基-5-芳基氨基 - 异噻唑-4-甲酰胺。 还包括互变异构异噻唑-3（2H） - 酮。
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