-
1.发明授权Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use 失效取代的氨基噻唑衍生物，药物组合物和使用方法公开(公告)号：US08563742B2
公开(公告)日：2013-10-22
申请号：US12547018
申请日：2009-08-25
IPC分类号： A61K31/427 , C07D417/12
CPC分类号： C07D417/14 , A61K31/425 , C07D417/12
摘要： Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译： 取代的氨基噻唑衍生物，其制备方法，包含取代的氨基噻唑的药物组合物，以及用于治疗人或动物疾病的方法。 该化合物可用作AgRP对黑皮质素受体的作用的抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体（包括肥胖相关病症）的调节有反应的疾病。
-
2.发明申请Substituted Aminothiazole Derivatives, Pharmaceutical Compositions, And Methods Of Use 失效取代的氨基噻唑衍生物，药物组合物和使用方法公开(公告)号：US20100056587A1
公开(公告)日：2010-03-04
申请号：US12547018
申请日：2009-08-25
IPC分类号： A61K31/427 , C07D409/12 , C07D409/14
CPC分类号： C07D417/14 , A61K31/425 , C07D417/12
摘要： Substituted aminothiazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted aminothiazole, and methods of use in treating human or animal disorders. The compounds may be useful as inhibitors of action of AgRP on a melanocortin receptor and thus may be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译： 取代的氨基噻唑衍生物，其制备方法，包含取代的氨基噻唑的药物组合物，以及用于治疗人或动物疾病的方法。 该化合物可用作AgRP对黑皮质素受体的作用的抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体（包括肥胖相关病症）的调节有反应的疾病。
-
3.发明授权Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof 有权取代的稠合咪唑衍生物，药物组合物及其使用方法公开(公告)号：US08759535B2
公开(公告)日：2014-06-24
申请号：US13028406
申请日：2011-02-16
申请人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
发明人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
IPC分类号： C07D417/12 , C07D235/30 , C07D513/04 , A61K31/437 , A61K31/428 , A61K31/4188 , A61K31/4168
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/4188 , A61K31/428 , A61K31/437 , C07D235/30 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供取代的稠合咪唑衍生物，其制备方法，包含取代的稠合咪唑衍生物的药物组合物和用于治疗炎症的方法。 取代的稠合咪唑衍生物可以控制血红素氧合酶的活性或活性和量的量。
-
4.发明申请Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof 有权取代的熔融咪唑衍生物，药物组合物及其使用方法公开(公告)号：US20110201604A1
公开(公告)日：2011-08-18
申请号：US13028406
申请日：2011-02-16
申请人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
发明人： Adnan M. M. Mjalli , Dharma Rao Polisetti , Jareer Nabeel Kassis , Matthew J. Kostura , Mustafa Guzel , Otis Clinton Attucks , Robert Carl Andrews , Samuel Victory , Suparna Gupta
IPC分类号： A61K31/428 , C07D417/12 , C07D417/14 , A61K31/5377 , C07D471/04 , A61K31/437 , A61K31/454 , A61K31/496 , A61K31/541 , A61K31/506 , A61P11/00 , A61P1/16 , A61P31/12 , A61P17/06 , A61P17/00 , A61P25/28 , A61P25/16 , A61P9/12 , A61P9/00 , A61P7/02 , A61P29/00 , A61P11/06 , A61P13/12 , A61P27/02 , A61P3/10 , A61P3/04 , A61P35/00
CPC分类号： C07D417/12 , A61K31/4168 , A61K31/4188 , A61K31/428 , A61K31/437 , C07D235/30 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供取代的稠合咪唑衍生物，其制备方法，包含取代的稠合咪唑衍生物的药物组合物和用于治疗炎症的方法。 取代的稠合咪唑衍生物可以控制血红素氧合酶的活性或活性和量的量。
-
公开(公告)号：US07820704B2
公开(公告)日：2010-10-26
申请号：US11110499
申请日：2005-04-20
申请人： Adnan M. M. Mjalli , Bapu R. Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty N. Arimilli , Robert C. Andrews , Samuel Victory , Ye E. Tian
发明人： Adnan M. M. Mjalli , Bapu R. Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty N. Arimilli , Robert C. Andrews , Samuel Victory , Ye E. Tian
IPC分类号： A61K31/427 , A61K31/381 , C07D277/38 , C07D409/12
CPC分类号： C07D277/52 , C07D239/42 , C07D277/26 , C07D277/42 , C07D277/50 , C07D277/56 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译： 本发明提供式（I）的取代杂芳基衍生物，其制备方法，包含式（I）化合物的药物组合物，以及用于治疗人或动物病症的方法。 本发明的化合物可用作AgRP对黑皮质素受体的作用抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体的调节（包括肥胖症 - 相关疾病。
-
6.发明申请SUBSTITUTED PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE TO TREAT OXIDATIVE STRESS 审中-公开取代的吡啶衍生物，药物组合物和用于治疗氧化应激的方法公开(公告)号：US20120071505A1
公开(公告)日：2012-03-22
申请号：US13278515
申请日：2011-10-21
IPC分类号： A61K31/47 , C07D215/24 , A61P9/00 , A61P9/10 , A61P9/12 , A61P3/10 , A61P13/12 , A61P25/28 , A61P25/16 , A61P25/00 , A61P11/06 , A61P11/00 , A61P17/00 , A61P27/02 , A61P27/12 , A61P35/00 , C07D215/54
CPC分类号： A61K31/443 , A61K31/44
摘要： Substituted pyridine derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted pyridine derivative, and methods of use in treating inflammation are provided. The substituted pyridine derivatives may control of the activity or the amount or both the activity and the amount of heme-oxygenase.
摘要翻译： 提供了取代的吡啶衍生物，其制备方法，包含取代的吡啶衍生物的药物组合物和用于治疗炎症的方法。 取代的吡啶衍生物可以控制血红素加氧酶的活性或活性和量的量。
-
公开(公告)号：US20050261294A1
公开(公告)日：2005-11-24
申请号：US11110499
申请日：2005-04-20
申请人： Adnan Mjalli , Bapu Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty Arimilli , Robert Andrews , Samuel Victory , Ye Tian
发明人： Adnan Mjalli , Bapu Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty Arimilli , Robert Andrews , Samuel Victory , Ye Tian
IPC分类号： A61K31/426 , A61K31/505 , A61K31/53 , C07D239/42 , C07D277/42 , C07D277/46 , C07D277/52 , C07D277/56 , C07D403/12 , C07D409/12 , C07D417/12 , C07D417/14
CPC分类号： C07D277/52 , C07D239/42 , C07D277/26 , C07D277/42 , C07D277/50 , C07D277/56 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译： 本发明提供式（I）的取代杂芳基衍生物，其制备方法，包含式（I）化合物的药物组合物，以及用于治疗人或动物病症的方法。 本发明的化合物可用作AgRP对黑皮质素受体的作用抑制剂，因此可用于治疗，治疗，控制或辅助治疗可能对黑皮质素受体的调节（包括肥胖症 - 相关疾病。
-
公开(公告)号：US20080194627A9
公开(公告)日：2008-08-14
申请号：US11518448
申请日：2006-09-11
申请人： Bin Shao , R. Goehring , Samuel Victory
发明人： Bin Shao , R. Goehring , Samuel Victory
IPC分类号： A61K31/4545 , A61K31/455 , C07D403/02
CPC分类号： C07D213/81 , C07D213/82 , Y10T436/145555
摘要： This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1—R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译： 本发明涉及式I的芳基取代的吡啶：或其药学上可接受的盐，前药或溶剂化物，其中Ar和R 1 -R 4定义在说明书中。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。
-
公开(公告)号：US20070010554A1
公开(公告)日：2007-01-11
申请号：US11518448
申请日：2006-09-11
申请人： Bin Shao , R. Goehring , Samuel Victory
发明人： Bin Shao , R. Goehring , Samuel Victory
IPC分类号： A61K31/4545 , A61K31/455 , C07D403/02
CPC分类号： C07D213/81 , C07D213/82 , Y10T436/145555
摘要： This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1—R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译： 本发明涉及式I的芳基取代的吡啶：或其药学上可接受的盐，前药或溶剂化物，其中Ar和R 1 -R 4定义在说明书中。 本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途 作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.043 秒)