公开(公告)号：US20150031748A1

公开(公告)日：2015-01-29

申请号：US14380583

申请日：2013-02-28

Applicant: Agency for Science, Technology and Research

Inventor： Walter Hunziker ,  Choon Peng Goh

IPC: C12N15/113 ,  G01N33/573 ,  C12N9/12 ,  C12N9/96 ,  C07K14/435 ,  C07K16/40 ,  G01N33/574

CPC classification number: C12N15/1137 ,  C07K14/43504 ,  C07K16/40 ,  C12N9/1229 ,  C12N9/96 ,  C12N2310/14 ,  C12Y207/04008 ,  G01N33/573 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/91235 ,  G01N2500/02 ,  G01N2800/52

Abstract: There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof.

Abstract translation: 提供了鉴定能够调节第一多肽和第二多肽之间的相互作用的候选试剂的方法，其中第一多肽是ZO-2 / TJP2或其功能变体，第二多肽是蜗牛锌指转录因子家族成员 或其功能变体。

公开(公告)号：US09963704B2

公开(公告)日：2018-05-08

申请号：US14380583

申请日：2013-02-28

Applicant: Agency for Science, Technology and Research

Inventor： Walter Hunziker ,  Choon Peng Goh

IPC: G01N33/574 ,  C12N15/113 ,  C07K16/40 ,  C12N9/12 ,  C12N9/96 ,  C07K14/435 ,  G01N33/573

CPC classification number: C12N15/1137 ,  C07K14/43504 ,  C07K16/40 ,  C12N9/1229 ,  C12N9/96 ,  C12N2310/14 ,  C12Y207/04008 ,  G01N33/573 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/91235 ,  G01N2500/02 ,  G01N2800/52

Abstract: There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof.