公开(公告)号：US20250122506A1

公开(公告)日：2025-04-17

申请号：US18687385

申请日：2022-09-16

Applicant: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

Inventor： Jianliang Xu ,  Walter Hunziker ,  Jaya Kausalya P

IPC: C12N15/113 ,  A61P35/00

Abstract: Disclosed is a method for treating a liver disease in a subject comprising administering a Tjp1 inhibitor to the subject. Also disclosed are a kit and a nucleic acid encoding a Tjp1 inhibitor.

公开(公告)号：US20170081723A1

公开(公告)日：2017-03-23

申请号：US15122554

申请日：2015-03-23

Applicant: Agency for Science, Technology and Research ,  National University of Singapore

Inventor： Axel Hillmer ,  Yijun Ruan ,  Fei Yao ,  Patrick Tan ,  Khay Guan Yeoh ,  Walter Hunziker ,  Audrey S M Teo ,  Yee Yen Sia

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: The present invention relates to a method for determining or making of a prognosis if a patient has cancer or is at an increased risk of having cancer, the method comprising testing for the presence of one or more cancer-associated fusion genes, or proteins derived thereof, in a sample obtained from a patient. More specifically, the present invention relates to fusion genes CLEC16A-EMP2, SNX2-PRDM6, MLL3-PRKAG2, DUS2L-PSKH1 and CLDN18-ARHGAP26 in gastric cancer. Use of the method and a kit when used in the method are also provided.

公开(公告)号：US20150031748A1

公开(公告)日：2015-01-29

申请号：US14380583

申请日：2013-02-28

Applicant: Agency for Science, Technology and Research

Inventor： Walter Hunziker ,  Choon Peng Goh

IPC: C12N15/113 ,  G01N33/573 ,  C12N9/12 ,  C12N9/96 ,  C07K14/435 ,  C07K16/40 ,  G01N33/574

CPC classification number: C12N15/1137 ,  C07K14/43504 ,  C07K16/40 ,  C12N9/1229 ,  C12N9/96 ,  C12N2310/14 ,  C12Y207/04008 ,  G01N33/573 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/91235 ,  G01N2500/02 ,  G01N2800/52

Abstract: There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof.

Abstract translation: 提供了鉴定能够调节第一多肽和第二多肽之间的相互作用的候选试剂的方法，其中第一多肽是ZO-2 / TJP2或其功能变体，第二多肽是蜗牛锌指转录因子家族成员 或其功能变体。

公开(公告)号：US09963704B2

公开(公告)日：2018-05-08

申请号：US14380583

申请日：2013-02-28

Applicant: Agency for Science, Technology and Research

Inventor： Walter Hunziker ,  Choon Peng Goh

IPC: G01N33/574 ,  C12N15/113 ,  C07K16/40 ,  C12N9/12 ,  C12N9/96 ,  C07K14/435 ,  G01N33/573

CPC classification number: C12N15/1137 ,  C07K14/43504 ,  C07K16/40 ,  C12N9/1229 ,  C12N9/96 ,  C12N2310/14 ,  C12Y207/04008 ,  G01N33/573 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/91235 ,  G01N2500/02 ,  G01N2800/52

Abstract: There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof.

公开(公告)号：US11820981B2

公开(公告)日：2023-11-21

申请号：US16333586

申请日：2017-09-14

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  NATIONAL UNIVERSITY OF SINGAPORE

Inventor： Walter Hunziker ,  Jianliang Xu ,  Jiong-Wei Wang ,  P. Jaya Kausalya

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  A61K35/761 ,  A61K38/17 ,  A61K38/18 ,  A61P9/10 ,  A61K31/713 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K31/713 ,  A61K35/761 ,  A61K38/1709 ,  A61K38/1825 ,  A61K38/1866 ,  A61K38/1883 ,  A61P9/10 ,  A61K31/7088 ,  A61K38/1808 ,  A61K38/1841 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/341 ,  C12N2310/531

Abstract: The invention is a method for treating a heart disease, in particular acute myocardial infarction (AMI) in a subject comprising the step of administering to the subject a Tjp1 inhibitor, wherein administration of said Tjp1 inhibitor promotes cardiomyocyte proliferation. The invention further includes use of Tjp1 inhibitor in the manufacture of a medicament for a heart disease, a patch, and a nucleic acid encoding a Tjp1 inhibitor. In a particular embodiment, the Tjp1 inhibitor is a nucleic acid, i.e. an siRNA or shRNA of Tjp1. The invention also includes administration of said Tjp1 inhibitor in combination with Neuregulin-1 (NRG1), Fibroblast growth factor (FGF), Vascular endothelial growth factor (VEGF) or Follistatin-like 1 (Fst1) and wherein said inhibitor is delivered in an adeno-associated virus of serotype 9 (AAV 9).

公开(公告)号：US20150250854A1

公开(公告)日：2015-09-10

申请号：US14664486

申请日：2015-03-20

Applicant: Agency for Science, Technology and Research

Inventor： Pascal Beguin ,  Walter Hunziker

IPC: A61K38/17 ,  C07K16/28

CPC classification number: A61K38/1709 ,  A61K38/00 ,  C07K14/4702 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/76 ,  G01N33/6872 ,  G01N2800/042 ,  Y10T436/143333

Abstract: The present invention relates to a novel gene encoding a protein termed voltage gated calcium channels β subunit anchoring regulator protein (VDCC BARP) or a peptide fragments thereof. The present invention also relates to the use of VDCC BARP in modulation of voltage gated calcium channels via altering the concentration of VDCC BARP or a peptide fragments thereof.

Abstract translation: 本发明涉及编码称为电压门控钙通道的蛋白质的新型基因 亚单位锚定调节蛋白（VDCC BARP）或其肽片段。 本发明还涉及VDCC BARP通过改变VDCC BARP或其肽片段的浓度来调节电压门控钙通道的用途。

公开(公告)号：US11583612B2

公开(公告)日：2023-02-21

申请号：US16804586

申请日：2020-02-28

Applicant: Agency for Science, Technology and Research ,  National University Hospital (Singapore) Pte Ltd ,  National University of Singapore ,  Singapore Health Services Pte Ltd

Inventor： Xian Jun Loh ,  Xinyi Su ,  Zengping Liu ,  Gopal Lingam ,  Veluchamy Amutha Barathi ,  Walter Hunziker

IPC: A61L27/18 ,  C08G81/00

Abstract: There is provided a material comprising a multi-block thermogelling polymer, said multi-block thermogelling polymer comprising a hydrophilic polymer block; a thermosensitive polymer block; and a hydrophobic polymer block, wherein the hydrophilic polymer block, the thermosensitive polymer block and the hydrophobic polymer block are chemically coupled together by at least one of urethane/carbamate, carbonate, ester linkages or combinations thereof, and wherein the material is suitable for use as a vitreous substitute. Also provided are a method of preparing said material and a synthetic vitreous humour or part thereof comprising said material.