公开(公告)号：US20150031748A1

公开(公告)日：2015-01-29

申请号：US14380583

申请日：2013-02-28

申请人： Agency for Science, Technology and Research

发明人： Walter Hunziker ,  Choon Peng Goh

IPC分类号： C12N15/113 ,  G01N33/573 ,  C12N9/12 ,  C12N9/96 ,  C07K14/435 ,  C07K16/40 ,  G01N33/574

CPC分类号： C12N15/1137 ,  C07K14/43504 ,  C07K16/40 ,  C12N9/1229 ,  C12N9/96 ,  C12N2310/14 ,  C12Y207/04008 ,  G01N33/573 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/91235 ,  G01N2500/02 ,  G01N2800/52

摘要： There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof.

摘要翻译： 提供了鉴定能够调节第一多肽和第二多肽之间的相互作用的候选试剂的方法，其中第一多肽是ZO-2 / TJP2或其功能变体，第二多肽是蜗牛锌指转录因子家族成员 或其功能变体。

公开(公告)号：US20040180848A1

公开(公告)日：2004-09-16

申请号：US10796177

申请日：2004-03-09

发明人： Stephen W. Fesik ,  Donald N. Halbert ,  Randy E. Metzger ,  Jeffrey A. McDowell ,  Mark E. Schurdak ,  Susan E. Morgan-Lappe ,  Aparna V. Sarthy

IPC分类号： A61K048/00

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N15/113 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/53 ,  C12Y207/01037 ,  C12Y207/04008 ,  C12Y207/11022

摘要： A method of killing cancer cells comprising inhibiting the function of a gene selected from the group consisting of CDK8, STK33, PRKCM, PRKACA, ACVR1B, CDK5R1, CDC42BPB, MPP6, and CDC42BPA; pharmaceutical compositions comprising an inhibitor of the same, and a method of detecting cellular hyperplasia.

公开(公告)号：US09963704B2

公开(公告)日：2018-05-08

申请号：US14380583

申请日：2013-02-28

申请人： Agency for Science, Technology and Research

发明人： Walter Hunziker ,  Choon Peng Goh

IPC分类号： G01N33/574 ,  C12N15/113 ,  C07K16/40 ,  C12N9/12 ,  C12N9/96 ,  C07K14/435 ,  G01N33/573

CPC分类号： C12N15/1137 ,  C07K14/43504 ,  C07K16/40 ,  C12N9/1229 ,  C12N9/96 ,  C12N2310/14 ,  C12Y207/04008 ,  G01N33/573 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/91235 ,  G01N2500/02 ,  G01N2800/52

摘要： There is provided a method of identifying candidate agents capable of modulating interaction between a first polypeptide and a second polypeptide, wherein the first polypeptide is ZO-2/TJP2 or a functional variant thereof and the second polypeptide is a Snail zinc finger transcription factor family member or a functional variant thereof.

公开(公告)号：US20060073581A1

公开(公告)日：2006-04-06

申请号：US11122793

申请日：2005-05-05

申请人： Aled Edwards ,  Akil Dharamsi ,  Masoud Vedadi ,  Nicole Brufatto ,  Teresa Clarke

发明人： Aled Edwards ,  Akil Dharamsi ,  Masoud Vedadi ,  Nicole Brufatto ,  Teresa Clarke

IPC分类号： G06F19/00 ,  C12N9/12

CPC分类号： C12N9/1229 ,  C07K2299/00 ,  C12Y207/04008

摘要： The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.

摘要翻译： 本发明涉及病原菌的新型药物靶标。 因此，本发明提供了包含SEQ ID NO：4所示氨基酸序列的纯化蛋白质。本发明还提供本发明多肽的生物化学和生物物理学特征。

公开(公告)号：US12077610B2

公开(公告)日：2024-09-03

申请号：US17956031

申请日：2022-09-29

申请人： The Research Foundation for The State University of New York

发明人： Arindam Bhattacharjee ,  Kerri Pryce

IPC分类号： C07K7/08 ,  A61K38/45 ,  A61K45/06 ,  A61P29/00

CPC分类号： C07K7/08 ,  A61K38/45 ,  A61P29/00 ,  A61K45/06 ,  C12Y207/04008

摘要： Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof.

公开(公告)号：US20050181388A1

公开(公告)日：2005-08-18

申请号：US10958216

申请日：2004-10-04

申请人： Aled Edwards ,  Akil Dharamsi ,  Masoud Vedadi ,  Muhammad Alam ,  Cheryl Arrowsmith ,  Donald Awrey ,  Bryan Beattie ,  Kristina Buzadzija ,  Veronica Canadien ,  Megan Domagala ,  Simon Houston ,  Dhushy Kanagarajah ,  Qin Li ,  Kamran Mansoury ,  Merry-Lynn McDonald ,  Kathleen Nethery-Brokx ,  Ivy Ng ,  Hui Ouyang ,  Benjamin Pinder ,  Dawn Richards ,  Matthew Tai ,  Rosanne Thalakada ,  Francois Vallee ,  Cristina Virag

发明人： Aled Edwards ,  Akil Dharamsi ,  Masoud Vedadi ,  Muhammad Alam ,  Cheryl Arrowsmith ,  Donald Awrey ,  Bryan Beattie ,  Kristina Buzadzija ,  Veronica Canadien ,  Megan Domagala ,  Simon Houston ,  Dhushy Kanagarajah ,  Qin Li ,  Kamran Mansoury ,  Merry-Lynn McDonald ,  Kathleen Nethery-Brokx ,  Ivy Ng ,  Hui Ouyang ,  Benjamin Pinder ,  Dawn Richards ,  Matthew Tai ,  Rosanne Thalakada ,  Francois Vallee ,  Cristina Virag

IPC分类号： C07K14/245 ,  C07K14/315 ,  C07K14/32 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/14 ,  C12N9/16 ,  C12N9/78 ,  C12N9/90 ,  C12Q1/68 ,  G01N33/00

CPC分类号： C12N9/0008 ,  C07K14/245 ,  C07K14/3156 ,  C07K14/32 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/1007 ,  C12N9/1077 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/1229 ,  C12N9/1235 ,  C12N9/1241 ,  C12N9/14 ,  C12N9/16 ,  C12N9/78 ,  C12N9/90 ,  C12N9/93 ,  C12Y101/01158 ,  C12Y102/01011 ,  C12Y201/01033 ,  C12Y201/01045 ,  C12Y201/01061 ,  C12Y204/02007 ,  C12Y205/01007 ,  C12Y207/01026 ,  C12Y207/01048 ,  C12Y207/04008 ,  C12Y207/06001 ,  C12Y207/07003 ,  C12Y207/07023 ,  C12Y207/07038 ,  C12Y304/11018 ,  C12Y304/24057 ,  C12Y305/04005 ,  C12Y306/01001 ,  C12Y501/03001 ,  C12Y504/02003 ,  C12Y599/01003 ,  C12Y601/01014 ,  C12Y601/0102 ,  C12Y601/01021 ,  C12Y603/02004 ,  C12Y603/02008 ,  C12Y603/02013 ,  C12Y603/04014 ,  C12Y604/01002

摘要： The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.

公开(公告)号：US20040180844A1

公开(公告)日：2004-09-16

申请号：US10385163

申请日：2003-03-10

发明人： Stephen W. Fesik ,  Donald N. Halbert ,  Randy E. Metzger ,  Jeffrey A. McDowell ,  Mark E. Schurdak ,  Susan E. Morgan-Lappe ,  Aparna V. Sarthy

IPC分类号： A61K048/00

CPC分类号： C12N15/1137 ,  A61K38/00 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/53 ,  C12Y207/01037 ,  C12Y207/04008 ,  C12Y207/11022

摘要： A method of killing cancer cells comprising inhibiting the function of a gene selected from the group consisting of CDK8, STK33, PRKCM, PRKACA, ACVR1B, CDK5R1, CDC42BPB, MPP6, and CDC42BPA; pharmaceutical compositions comprising an inhibitor of the same, and a method of detecting cellular hyperplasia.

摘要翻译： 一种杀死癌细胞的方法，包括抑制选自CDK8，STK33，PRKCM，PRKACA，ACVR1B，CDK5R1，CDC42BPB，MPP6和CDC42BPA的基因的功能; 包含其抑制剂的药物组合物和检测细胞增生的方法。