公开(公告)号：US09221875B2

公开(公告)日：2015-12-29

申请号：US14321624

申请日：2014-07-01

Applicant: Agency for Science, Technology and Research

Inventor： Yi-Yan Yang ,  Zhan Yuin Ong

IPC: A61K38/08 ,  C07K7/06 ,  C07K7/08 ,  A01N47/44 ,  A61K38/00

CPC classification number: C07K7/08 ,  A01N47/44 ,  A61K38/00 ,  A61K38/08 ,  C07K7/06 ,  C07K14/4723 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/492 ,  A01N33/04

Abstract: Disclosed is the method of treating keratits in a subject thereof comprising administering into the subject an amphiphilic peptides of the present disclosure. Also disclosed are methods of removing biofilm from cornea.

Abstract translation: 公开了治疗本发明的角蛋白的方法，其包括向受试者施用本公开的两亲性肽。 还公开了从角膜去除生物膜的方法。

公开(公告)号：US20150005228A1

公开(公告)日：2015-01-01

申请号：US14321624

申请日：2014-07-01

Applicant: Agency for Science, Technology and Research

Inventor： Yi-Yan Yang ,  Zhan Yuin Ong

IPC: C07K7/08 ,  C07K7/06

CPC classification number: C07K7/08 ,  A01N47/44 ,  A61K38/00 ,  A61K38/08 ,  C07K7/06 ,  C07K14/4723 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/492 ,  A01N33/04

Abstract: Disclosed is the method of treating keratits in a subject thereof comprising administering into the subject an amphiphilic peptides of the present disclosure. Also disclosed are methods of removing biofilm from cornea.

Abstract translation: 公开了治疗本发明的角蛋白的方法，其包括向受试者施用本公开的两亲性肽。 还公开了从角膜去除生物膜的方法。

公开(公告)号：US20150080289A1

公开(公告)日：2015-03-19

申请号：US14353531

申请日：2013-08-29

Applicant: Agency for Science, Technology and Research

Inventor： Yi-Yan Yang ,  Zhan Yuin Ong

IPC: C07K7/08 ,  A01N47/44 ,  C07K7/06

CPC classification number: C07K7/08 ,  A01N47/44 ,  A61K38/00 ,  A61K38/08 ,  C07K7/06 ,  C07K14/4723 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/492 ,  A01N33/04

Abstract: Disclosed are amphiphilic peptides. Also disclosed are methods of treating proliferative disease, bacterial infection, viral infection and fungal infection, endotoxin neutralization and a method of removing biofilm. Also disclosed is the use of the amphiphilic peptides.

Abstract translation: 公开的是两亲肽。 还公开了治疗增殖性疾病，细菌感染，病毒感染和真菌感染，内毒素中和以及除去生物膜的方法的方法。 还公开了两亲肽的用途。

公开(公告)号：US09273096B2

公开(公告)日：2016-03-01

申请号：US14353531

申请日：2013-08-29

Applicant: Agency for Science, Technology and Research

Inventor： Yi-Yan Yang ,  Zhan Yuin Ong

IPC: A61K38/00 ,  A61K38/08 ,  C07K7/06 ,  C07K7/08 ,  A01N47/44

CPC classification number: C07K7/08 ,  A01N47/44 ,  A61K38/00 ,  A61K38/08 ,  C07K7/06 ,  C07K14/4723 ,  Y02A50/385 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/471 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  Y02A50/492 ,  A01N33/04

Abstract: Disclosed are amphiphilic peptides. Also disclosed are methods of treating proliferative disease, bacterial infection, viral infection and fungal infection, endotoxin neutralization and a method of removing biofilm. Also disclosed is the use of the amphiphilic peptides.

Abstract translation: 公开的是两亲肽。 还公开了治疗增殖性疾病，细菌感染，病毒感染和真菌感染，内毒素中和的方法，以及除去生物膜的方法。 还公开了两亲肽的用途。

公开(公告)号：US09062160B1

公开(公告)日：2015-06-23

申请号：US14162222

申请日：2014-01-23

Applicant: International Business Machines Corporation ,  Agency For Science, Technology and Research ,  Universidad del Pais Vasco/Euskal Herriko Unibertsitatea

Inventor： Julian M. W. Chan ,  Daniel J. Coady ,  Amanda C. Engler ,  Jeannette M. Garcia ,  James L. Hedrick ,  Zhan Yuin Ong ,  Haritz Sardon ,  Yi Yan Yang

IPC: C08G73/24 ,  C08G71/04 ,  C08G65/00 ,  C08G73/02

CPC classification number: C08G71/04 ,  C08G65/007 ,  C08G73/02 ,  C08G73/0206

Abstract: One catalyst-free method of forming a polyurethane comprises forming a first emulsion comprising a first monomer, a surfactant, a water immiscible organic solvent, and water. The first monomer comprises two or more pentafluorophenyl carbonate groups. The first emulsion is combined with an aqueous mixture containing a second monomer comprising two or more nucleophilic amine groups, thereby forming a second emulsion. The first and second monomers of the second emulsion are allowed to react by interfacial polymerization, thereby forming a polyurethane. The polyurethane can have a number average molecular weight (Mn) of about 30000 to about 80000. The method is compatible with introducing pendant functionality into the polyurethane by way of cyclic carbonate precursors to the first monomer.

Abstract translation: 形成聚氨酯的一种无催化剂的方法包括形成包含第一单体，表面活性剂，与水不混溶的有机溶剂和水的第一乳液。 第一单体包含两个或多个五氟苯基碳酸酯基团。 将第一乳液与含有包含两个或多个亲核胺基团的第二单体的含水混合物组合，从而形成第二乳液。 通过界面聚合使第二乳液的第一和第二单体反应，由此形成聚氨酯。 聚氨酯的数均分子量（Mn）可以为约30000至约80000.该方法与通过环状碳酸酯前体向第一单体引入侧链官能团相容。