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1.发明授权Catalyst-free methods of forming polyurethanes from pentafluorophenyl carbonates 有权从五氟苯基碳酸酯形成聚氨酯的无催化剂方法公开(公告)号：US09062160B1
公开(公告)日：2015-06-23
申请号：US14162222
申请日：2014-01-23
申请人： International Business Machines Corporation , Agency For Science, Technology and Research , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea
发明人： Julian M. W. Chan , Daniel J. Coady , Amanda C. Engler , Jeannette M. Garcia , James L. Hedrick , Zhan Yuin Ong , Haritz Sardon , Yi Yan Yang
CPC分类号： C08G71/04 , C08G65/007 , C08G73/02 , C08G73/0206
摘要： One catalyst-free method of forming a polyurethane comprises forming a first emulsion comprising a first monomer, a surfactant, a water immiscible organic solvent, and water. The first monomer comprises two or more pentafluorophenyl carbonate groups. The first emulsion is combined with an aqueous mixture containing a second monomer comprising two or more nucleophilic amine groups, thereby forming a second emulsion. The first and second monomers of the second emulsion are allowed to react by interfacial polymerization, thereby forming a polyurethane. The polyurethane can have a number average molecular weight (Mn) of about 30000 to about 80000. The method is compatible with introducing pendant functionality into the polyurethane by way of cyclic carbonate precursors to the first monomer.
摘要翻译： 形成聚氨酯的一种无催化剂的方法包括形成包含第一单体，表面活性剂，与水不混溶的有机溶剂和水的第一乳液。 第一单体包含两个或多个五氟苯基碳酸酯基团。 将第一乳液与含有包含两个或多个亲核胺基团的第二单体的含水混合物组合，从而形成第二乳液。 通过界面聚合使第二乳液的第一和第二单体反应，由此形成聚氨酯。 聚氨酯的数均分子量（Mn）可以为约30000至约80000.该方法与通过环状碳酸酯前体向第一单体引入侧链官能团相容。
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公开(公告)号：US20150157723A1
公开(公告)日：2015-06-11
申请号：US14097488
申请日：2013-12-05
申请人： International Business Machines Corporation , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea , Agency For Science, Technology and Research
发明人： Julian M. W. Chan , Amanda C. Engler , James L. Hedrick , Xiyu Ke , Victor W.L. Ng , Haritz Sardon , Jeremy P. K. Tan , Yi Yan Yang
IPC分类号： A61K47/34 , A61K31/713 , A61K31/704 , A61K38/16
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/704 , A61K31/713 , A61K38/00 , A61K38/16 , C08G64/0241 , C08G64/183 , C08L69/00
摘要： Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
摘要翻译： 纳米颗粒包含药物，第一嵌段聚合物和第二嵌段聚合物。 第一嵌段聚合物具有聚（环氧乙烷）（PEO）嵌段和带有侧链芳香族含氮杂环（N-杂环）的聚碳酸酯嵌段）。 N-杂环可以是碱的形式，碱的氢盐，碱的磺基甜菜碱加合物或其组合。 第二嵌段聚合物具有PEO嵌段和带有侧链儿茶酚基团的聚碳酸酯嵌段，其可以儿茶酚，氧化形式的儿茶酚和/或邻苯二酚的聚合形式存在。 纳米颗粒可以分散在水中并且能够控制释放药物。
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公开(公告)号：US09717797B2
公开(公告)日：2017-08-01
申请号：US14097488
申请日：2013-12-05
申请人： International Business Machines Corporation , Agency For Science, Technology and Research , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea
发明人： Julian M. W. Chan , Amanda C. Engler , James L. Hedrick , Xiyu Ke , Victor W. L. Ng , Haritz Sardon , Jeremy P. K. Tan , Yi Yan Yang
IPC分类号： A61K9/00 , A61K47/34 , A61K31/704 , A61K31/713 , A61K9/51 , C08G64/02 , C08G64/18 , A61K38/16 , A61K38/00
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/704 , A61K31/713 , A61K38/00 , A61K38/16 , C08G64/0241 , C08G64/183 , C08L69/00
摘要： Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
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公开(公告)号：US20180228835A1
公开(公告)日：2018-08-16
申请号：US15954776
申请日：2018-04-17
发明人： Willy Chin , Daniel J. Coady , Richard A. Dipietro , Amanda C. Engler , James L. Hedrick , Ashlynn L. Z. Lee , Victor W. L. Ng , Zhan-Yuin Ong , Yi Yan Yang
IPC分类号： A61K31/785 , C08G64/02 , A01N25/10 , A01N33/12 , A61K31/80
摘要： Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
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公开(公告)号：US20170073471A1
公开(公告)日：2017-03-16
申请号：US15361313
申请日：2016-11-25
发明人： Gregory Breyta , Julian M.W. Chan , Daniel J. Coady , Amanda C. Engler , Jeannette M. Garcia , Wei Han , James L. Hedrick , Alshakim Nelson , Robert J. Ono , Yi Yan Yang , Mu San Zhang
IPC分类号： C08G69/48 , A61K8/85 , A01N37/12 , A61Q17/00 , A01N47/06 , A61K8/88 , A01N43/58 , C08G64/42 , A61K8/84 , C08G63/91 , A01N37/20
CPC分类号： C08G69/48 , A01N37/12 , A01N37/18 , A01N37/20 , A01N37/44 , A01N43/40 , A01N43/58 , A01N43/60 , A01N47/06 , A61K8/84 , A61K8/85 , A61K8/86 , A61K8/88 , A61K31/785 , A61K31/787 , A61K45/06 , A61K2800/10 , A61K2800/74 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/00 , A61Q17/005 , A61Q19/007 , C08G63/916 , C08G64/42 , C08G73/0206 , C08G73/024 , C08G73/0273 , C08G73/028 , C08G73/0293 , C08G73/0633 , C08G2650/02 , C08G2650/38 , C08G2650/58 , C08L77/04 , C08L79/02 , C11D3/3723 , C11D3/48 , D21H17/55 , D21H17/56 , D21H21/36 , A61K2300/00
摘要： A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
摘要翻译： 已经通过大量的缩聚合成了许多阳离子抗微生物聚合物。 形成的初始聚合物具有主链叔氮，随后使用合适的季铵化剂（例如烷基卤）季铵化。 阳离子聚合物包括具有阳离子重复单元的聚酰胺，聚碳酸酯，聚赖氨酸和聚胍，所述阳离子重复单元包含季铵氮作为主链氮。 阳离子聚合物可以对革兰氏阴性，革兰氏阳性微生物和/或真菌具有活性。
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公开(公告)号：US09469726B2
公开(公告)日：2016-10-18
申请号：US14506733
申请日：2014-10-06
发明人： Daniel J. Coady , Amanda C. Engler , James L. Hedrick , Xiyu Ke , Yi Yan Yang
CPC分类号： C08G64/18 , A61K9/0019 , A61K9/146 , A61K45/06 , C08G64/0233 , C08G64/0241 , C08G64/30 , C08G64/42
摘要： Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water-soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution.
摘要翻译： 通过有机酸催化的开环聚合（ROP）制备具有活性酯侧链的环状碳酸酯单体的水溶性可生物降解聚合物。 包含活性酯侧链的初始聚合物用氨基醇处理，氨基醇将活性酯基转变成带有单羟基烷基和/或二羟基烷基的N-取代酰胺基，从而形成水溶性聚合物。 水溶性聚合物是无毒的，并且在缓冲的血清溶液中表现出隐形性质。
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7.发明申请CATIONIC POLYMERS FOR ANTIMICROBIAL APPLICATIONS AND DELIVERY OF BIOACTIVE MATERIALS 有权用于抗生素应用和递送生物材料的阳离子聚合物公开(公告)号：US20140220093A1
公开(公告)日：2014-08-07
申请号：US14246045
申请日：2014-04-05
发明人： Daniel J. Coady , Amanda C. Engler , Kazuki Fukushima , James L. Hedrick , Jeremy P. K. Tan , Yi Yan Yang
IPC分类号： A01N37/44
CPC分类号： A01N37/44 , A01N33/12 , A61K48/0041 , C08G83/004 , C12N15/88 , A01N25/10 , A01N2300/00
摘要： A cationic star polymer is disclosed of the general formula (1): wherein w′ is a positive number greater than or equal to 3, I′ is a dendritic polyester core covalently linked to w′ independent peripheral linear cationic polymer chains P′. Each of the chains P′ comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group. The quaternary amine group comprises a divalent methylene group directly covalently linked to i) a positive charged nitrogen and ii) an aromatic ring.
摘要翻译： 公开了通式（1）的阳离子星形聚合物：其中w'是大于或等于3的正数，I'是与w'独立的外部线性阳离子聚合物链P'共价连接的树枝状聚酯芯。 每个链P'包含阳离子重复单元，其包含i）选自脂族碳酸酯，脂族酯，脂族氨基甲酸酯，脂族脲，脂族硫代氨基甲酸酯，脂族二硫代碳酸酯及其组合的骨架官能团，和ii） 侧链包含季胺基。 季胺基包括与i）正电荷氮和ii）芳环直接共价连接的二价亚甲基。
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8.发明申请1,3,6-DIOXAZOCAN-2-ONES AND ANTIMICROBIAL CATIONIC POLYCARBONATES THEREFROM 有权1,3,6-DIOXAZOCAN-2-ONES和抗微生物阳离子聚碳酸酯公开(公告)号：US20150264932A1
公开(公告)日：2015-09-24
申请号：US14223630
申请日：2014-03-24
发明人： Daniel J. Coady , Amanda C. Engler , Jeanette M. Garcia , James L. Hedrick , Jeremy P.K. Tan , Yi Yan Yang
IPC分类号： A01N47/06 , C08G64/02 , C07D273/01
CPC分类号： A01N47/06 , A01N43/72 , C07D273/01 , C08G64/0241 , C08G64/42
摘要： Eight-membered ring cyclic carbonates comprising a ring nitrogen at position 6 (1,3,6-dioxazocan-2-ones) were prepared by reaction of precursor diols with active carbonates. The ring nitrogen is linked to a pendant group Y′ via a methylene linking group. The cyclic carbonates undergo organocatalyzed ring opening polymerization to form an initial polycarbonate comprising a backbone tertiary amine group. Quaternization of the initial polycarbonates forms cationic polycarbonates comprising a positive-charged backbone quaternary nitrogen. The cationic polycarbonates can be potent antimicrobial agents.
摘要翻译： 通过前体二醇与活性碳酸酯的反应来制备包含第6位的环氮（1,3,6-二氧杂环己烷-2-酮）的八元环状碳酸酯。 环氮通过亚甲基连接基团与侧基Y'连接。 环状碳酸酯进行有机催化的开环聚合，形成包含主链叔胺基团的初始聚碳酸酯。 初始聚碳酸酯的季铵化形成包含正电荷的主链季氮的阳离子聚碳酸酯。 阳离子聚碳酸酯可以是有效的抗微生物剂。
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公开(公告)号：US20150037390A1
公开(公告)日：2015-02-05
申请号：US13956821
申请日：2013-08-01
发明人： Daniel J. Coady , Richard A. Dipietro , Amanda C. Engler , James L. Hedrick , Shao Qiong Liu , Hareem T. Maune , Alshakim Nelson , Jed W. Pitera , Shrinivas Venkataraman , Yi Yan Yang
IPC分类号： A61K9/70 , C07C275/42
CPC分类号： A61K9/70 , A61K9/0092 , A61K31/166 , A61K31/17 , A61K31/43 , A61K31/431 , A61K31/616 , A61K47/6921 , A61K47/6953
摘要： Cationic, anionic, and/or zwitterionic bis-urea compounds self-assemble by non-covalent interactions in aqueous solution to form high aspect ratio nanofibers. The nanofibers reversibly bind drugs by non-covalent interactions, forming drug compositions for exhibiting sustained release of the drug.
摘要翻译： 阳离子，阴离子和/或两性离子双脲化合物通过在水溶液中的非共价相互作用自组装形成高纵横比纳米纤维。 纳米纤维通过非共价相互作用可逆地结合药物，形成用于显示药物持续释放的药物组合物。
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公开(公告)号：US20140301967A1
公开(公告)日：2014-10-09
申请号：US13859037
申请日：2013-04-09
发明人： Willy Chin , Daniel J. Coady , Richard A. Dipietro , Amanda C. Engler , James L. Hedrick , Ashlynn L. Z. Lee , Victor W. L. Ng , Zhan-Yuin Ong , Yi Yan Yang
IPC分类号： A61K31/785 , A61K31/80
CPC分类号： A61K31/785 , A01N33/12 , A61K31/80 , C08G64/0241 , Y02A50/473 , A01N25/10
摘要： Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
摘要翻译： 通过有机催化开环聚合制备具有一个或两个阳离子聚碳酸酯链的抗微生物阳离子聚合物。 一种抗微生物阳离子聚合物具有基本上由连接到一个或两个端基的阳离子碳酸酯重复单元组成的聚合物链。 末端基团可包含共价结合形式的生物活性化合物如胆固醇。 其它抗微生物阳离子聚合物具有无规共聚碳酸酯链，其包含具有共价结合形式的维生素E和/或维生素D2的疏水重复单元的较小摩尔分数。 阳离子聚合物对革兰氏阴性和革兰氏阳性微生物和真菌表现出高活性和选择性。
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