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公开(公告)号：US20070066819A1
公开(公告)日：2007-03-22
申请号：US11531794
申请日：2006-09-14
IPC分类号： C07D257/10
CPC分类号： C07D255/04 , C07D271/07 , C07D413/12
摘要： The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands.
摘要翻译： 本发明涉及制备可用于制备胃泌素和胆囊收缩素受体配体的苯并[e] [1,2,4]三氮杂-二酮衍生物的新方法。
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公开(公告)号：US07582753B2
公开(公告)日：2009-09-01
申请号：US11531794
申请日：2006-09-14
IPC分类号： C07D255/04
CPC分类号： C07D255/04 , C07D271/07 , C07D413/12
摘要： The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands.
摘要翻译： 本发明涉及制备可用于制备胃泌素和胆囊收缩素受体配体的苯并[e] [1,2,4]三氮杂-二酮衍生物的新方法。
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公开(公告)号：US07060725B2
公开(公告)日：2006-06-13
申请号：US10434387
申请日：2003-05-08
申请人： Ahmed Abdel-Magid , Cynthia Maryanoff , Steven Mehrman , Kirk Sorgi , Frank Villani , Cheryl Kordik , Allen B. Reitz , Bruce Maryanoff
发明人： Ahmed Abdel-Magid , Cynthia Maryanoff , Steven Mehrman , Kirk Sorgi , Frank Villani , Cheryl Kordik , Allen B. Reitz , Bruce Maryanoff
IPC分类号： C07D323/00 , A61K31/335
摘要： The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
摘要翻译： 本发明涉及新的式（I）化合物，其中X，R 1，R 2，R 3，R 2， > 4，R 5和R 6如说明书中所述，制备方法和包含所述衍生物的药物组合物。 本发明的化合物可用于治疗癫痫。 本发明还涉及一种制备式（ⅩⅩ）化合物的方法，其中X，R 3，R 4，R 5， >和R 6'如说明书中所述。
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公开(公告)号：US20060270856A1
公开(公告)日：2006-11-30
申请号：US11406794
申请日：2006-04-19
申请人： Ahmed Abdel-Magid , Steven Mehrman
发明人： Ahmed Abdel-Magid , Steven Mehrman
IPC分类号： C07D213/57 , C07D207/30 , C07C311/50
CPC分类号： C07D333/58 , C07C303/34 , C07D207/30 , C07D209/14 , C07D211/96 , C07D213/57 , C07D307/81 , C07D409/12 , C07H1/00 , C07H7/02 , C07C307/06
摘要： The present invention is directed to novel process for the preparation of sulfonylimine and sulfamide derivatives.
摘要翻译： 本发明涉及制备磺酰亚胺和磺酰胺衍生物的新方法。
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公开(公告)号：US07560459B2
公开(公告)日：2009-07-14
申请号：US11265670
申请日：2005-11-02
IPC分类号： A61K31/255 , C07C311/01
摘要： The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy.The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
摘要翻译： 本发明涉及式（I）的新化合物，其中X，R 1，R 2，R 3，R 4，R 5和R 6如说明书中所述，制备方法和包含所述衍生物的药物组合物。 本发明的化合物可用于治疗癫痫。 本发明还涉及制备式（XX）化合物的方法，其中X，R 3，R 4，R 5和R 6如说明书中所述。
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6.发明申请Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents 审中-公开用作抗惊厥剂的新型苯并稠合的杂芳基磺酰胺衍生物公开(公告)号：US20060276528A1
公开(公告)日：2006-12-07
申请号：US11359626
申请日：2006-02-22
IPC分类号： A61K31/404 , A61K31/381 , A61K31/4025 , A61K31/343 , C07D333/02
CPC分类号： C07D307/81 , C07D209/14 , C07D333/58 , C07D409/12
摘要： The present invention is directed to novel benzo-fused heteroaryl sulfamide derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders. The present invention is further directed to a crystalline form of N-(benzo[b]thien-3-ylmethyl)-sulfamide and a process for its preparation.
摘要翻译： 本发明涉及新颖的苯并稠合杂芳基磺酰胺衍生物，含有它们的药物组合物及其在治疗癫痫和相关疾病中的用途。 本发明还涉及N-（苯并[b]噻吩-3-基甲基） - 磺酰胺的结晶形式及其制备方法。
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公开(公告)号：US20060058373A1
公开(公告)日：2006-03-16
申请号：US11265670
申请日：2005-11-02
IPC分类号： A61K31/255 , C07C311/45 , A61K31/695
摘要： The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy. The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.
摘要翻译： 本发明涉及新的式（I）化合物，
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8.发明申请NOVEL LYSINE SALTS OF 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACID DERIVATIVES 有权4 - （（苯甲基）硫代） - 氧化戊酸衍生物的新型赖氨酸盐公开(公告)号：US20070060649A1
公开(公告)日：2007-03-15
申请号：US11531464
申请日：2006-09-13
IPC分类号： A61K31/205 , C07C323/34
CPC分类号： C07C323/20
摘要： The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts,
摘要翻译： 本发明涉及含有它们的新型赖氨酸盐，药物组合物及其用于治疗由PPARδ调节的病症和状况的用途。 本发明进一步涉及制备所述赖氨酸盐的新方法，
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9.发明授权公开(公告)号：US09024009B2
公开(公告)日：2015-05-05
申请号：US12207252
申请日：2008-09-09
申请人： Ahmed F. Abdel-Magid , Maureen Chislom , Steven Mehrman , Lorraine Scott , Kenneth M. Wells , Fan Zhang-Plasket , Sumihiro Nomura , Mitsuya Hongu , Yuichi Koga
发明人： Ahmed F. Abdel-Magid , Maureen Chislom , Steven Mehrman , Lorraine Scott , Kenneth M. Wells , Fan Zhang-Plasket , Sumihiro Nomura , Mitsuya Hongu , Yuichi Koga
IPC分类号： C07H7/04 , C07H7/06 , C07D409/10 , C07D409/14 , C07D417/14 , A61K31/7042 , A61K31/7056 , A61K31/706 , A61P3/10 , C07D309/12 , C07D309/10
CPC分类号： C07D409/10 , C07D309/10 , C07D309/12 , C07D409/14 , C07D417/14
摘要： The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
摘要翻译： 本发明涉及一种制备具有抑制活性的化合物的新方法，所述化合物对存在于肠或肾中的钠依赖性葡萄糖转运蛋白（SGLT）具有抑制活性。
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10.发明申请公开(公告)号：US20090233874A1
公开(公告)日：2009-09-17
申请号：US12207252
申请日：2008-09-09
申请人： Ahmed F. Abdel-Magid , Maureen Chisholm , Steven Mehrman , Lorraine Scott , Kenneth M. Wells , Fan Zhang-Plasket , Sumihiro Nomura , Mitsuya Hongu , Yuichi Koga
发明人： Ahmed F. Abdel-Magid , Maureen Chisholm , Steven Mehrman , Lorraine Scott , Kenneth M. Wells , Fan Zhang-Plasket , Sumihiro Nomura , Mitsuya Hongu , Yuichi Koga
IPC分类号： A61K31/706 , C07H7/06 , A61P3/10
CPC分类号： C07D409/10 , C07D309/10 , C07D309/12 , C07D409/14 , C07D417/14
摘要： The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
摘要翻译： 本发明涉及一种制备具有抑制活性的化合物的新方法，所述化合物对存在于肠或肾中的钠依赖性葡萄糖转运蛋白（SGLT）具有抑制活性。
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