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1.发明授权Process for the preparation of arylalkylamines and substituted arylalkylamines 失效制备芳基烷基胺和取代的芳基烷基胺的方法
公开(公告)号：US5175368A
公开(公告)日：1992-12-29
申请号：US908587
申请日：1992-06-29
IPC分类号： C07C213/02 , C07C215/52
CPC分类号： C07C213/02 , C07C215/52
摘要： Arylalkylamines (as the hydrochloride salt), e.g. tyramine hydrochloride, are prepared by hydrogenating substituted or unsubstituted aryl-.alpha.-oximinoalkyl ketones, e.g. p-hydroxyisonitroacetophenone, in either in an aqueous reaction medium comprising hydrochloric acid, essentially without the presence of a lower alkyl alcohol in said reaction medium, or in an aqueous reaction medium comprising water, hydrochloric acid, and a lower alkyl alcohol, wherein the alcohol comprises less than about 90% by volume of the reaction medium. A substituent on the aryl portion of the aryl-.alpha.-oximinoalkyl ketone must be on a position which activates the aromatic ring.
摘要翻译： 芳烷基胺（作为盐酸盐），例如 通过氢化取代或未取代的芳基-α-肟基烷基酮来制备盐酸酪胺。 在包含盐酸的水性反应介质中，在所述反应介质中基本上不存在低级烷基醇，或者在包含水，盐酸和低级烷基醇的水性反应介质中，其中所述醇与对羟基硝基苯乙酮 包含小于约90体积％的反应介质。 芳基-α-肟基烷基酮的芳基部分上的取代基必须在活化芳环的位置。
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2.发明授权
公开(公告)号：US5220067A
公开(公告)日：1993-06-15
申请号：US859774
申请日：1992-03-30
IPC分类号： B01J23/42 , B01J23/44 , C07B61/00 , C07C209/40 , C07C211/16 , C07C213/02 , C07C215/46 , C07C215/48
CPC分类号： C07C213/02
摘要： This invention provides a process for directly preparing hydrohalide salts of arylethylamines from (.alpha.-chloro-.alpha.-oximino)acetophenones. The process involves hydrogenation in presence of a transition metal catalyst in an organic acid in substantial absence of moisture. The process is illustrated by conversion of 4-hydroxy (.alpha.-chloro-.alpha.-oximino)acetophenone to Tyramine hydrochloride: ##STR1##
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公开(公告)号：US5220066A
公开(公告)日：1993-06-15
申请号：US859773
申请日：1992-03-30
IPC分类号： B01J23/42 , B01J23/44 , C07B61/00 , C07C209/40 , C07C211/16 , C07C213/02 , C07C215/46 , C07C215/48
CPC分类号： C07C213/02
摘要： This invention provides a process for directly preparing arylethylamines and their salts from (.alpha.-halo-.alpha.-oximino)acetophenones. The process involves hydrogenation in presence of a transition metal catalyst. The process is illustrated by conversion of 4-hydroxy-(.alpha.-chloro-.alpha.-oximino)acetophenone to Tyramine hydrochloride: ##STR1##
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公开(公告)号：US5523378A
公开(公告)日：1996-06-04
申请号：US529697
申请日：1995-09-18
CPC分类号： C08G61/02 , C07C29/145 , C08F12/24 , Y02P20/582
摘要： The present invention provides a unique and novel way of producing polyhydroxystyrene which comprises the steps of (a) heating 4-hydroxyacetophenone under suitable hydrogenation conditions of temperature and pressure in the presence of a suitable palladium catalyst and a basic material and for a sufficient period of time to form 4-hydroxyphenylmethylcarbinol; (b) heating 4-hydroxyphenylmethylcarbinol under suitable conditions of temperature and pressure and for a sufficient period of time to form said polyhydroxystyrene.
摘要翻译： 本发明提供了一种独特且新颖的多羟基苯乙烯生产方法，该方法包括以下步骤：（a）在合适的钯催化剂和碱性物质存在下，在合适的温度和压力的氢化条件下加热4-羟基苯乙酮， 形成4-羟基苯基甲基甲醇的时间; （b）在合适的温度和压力条件下加热4-羟基苯基甲基甲醇并持续足够的时间以形成所述多羟基苯乙烯。
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公开(公告)号：US4607125A
公开(公告)日：1986-08-19
申请号：US721007
申请日：1985-04-08
申请人： Graham N. Mott
发明人： Graham N. Mott
IPC分类号： C07C45/46
CPC分类号： C07C45/46
摘要： A process of acylating a monocyclic phenolic reactant, e.g. phenol to a hydroxy aromatic ketone, e.g. 4-hydroxyacetophenone, by contacting the phenolic reactant with about 0.4 to 0.8 moles of a carboxylic acid anhydride, e.g. acetic anhydride as acylating agent per mole of phenolic reactant of in the presence of a Friedel-Crafts catalyst, e.g. hydrogen fluoride. The process generally results in phenolic reactant conversions of at least about 80% and reaction selectivities to hydroxy aromatic ketone of at least about 70%.
摘要翻译： 酰化单环酚类反应物的方法，例如 苯酚转化成羟基芳族酮，例如 通过使酚类反应物与约0.4至0.8摩尔的羧酸酐接触，例如4-羟基苯乙酮。 乙酸酐作为酰化剂/摩尔酚反应物，在Friedel-Crafts催化剂存在下，例如， 氟化氢。 该方法通常导致至少约80％的酚反应物转化率和至少约70％的羟基芳族酮的反应选择性。
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公开(公告)号：US5166418A
公开(公告)日：1992-11-24
申请号：US803744
申请日：1991-12-04
申请人： Joel D. Hendricks , Graham N. Mott
发明人： Joel D. Hendricks , Graham N. Mott
IPC分类号： C07C51/12
CPC分类号： C07C51/12
摘要： A method is provided for the preparation of ibuprofen by carbonylating 1-(4'-isobutylphenyl)ethanol (IBPE) with carbon monoxide comprising initially a reaction mixture comprising IBPE, ibuprofen and a catalyst for the carbonylation with carbon monoxide under conditions to initiate the reaction, and continuing to feed carbon monoxide to the composition to produce the desired yield of ibuprofen. Preferably the catalyst comprises palladium and a monodentate phosphine ligand. The presence of ibuprofen in the feed composition when the reaction is initiated with CO makes it possible to obtain high selectivities to ibuprofen with substantially complete conversion of IBPE at much shorter reaction times than if no ibuprofen is present initially.
摘要翻译： 提供了一种通过用一氧化碳羰基化1-（4'-异丁基苯基）乙醇（IBPE）来制备布洛芬的方法，该方法包括最初包含IBPE，布洛芬的反应混合物和用于一氧化碳羰基化的催化剂，以引发反应 并且继续将一氧化碳供给到组合物中以产生所需的布洛芬产率。 优选地，催化剂包括钯和单齿膦配体。 当用CO引发反应时，饲料组合物中布洛芬的存在使得有可能获得对布洛芬的高选择性，在比起没有首先出现布洛芬的短的反应时间下，基本上完全转化IBPE。
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7.发明授权Process for preparing phenethanol ethers by the reduction of corresponding phenylglyoxal acetals 失效通过还原相应的苯乙醛缩醛制备苯乙醇醚的方法
公开(公告)号：US5124489A
公开(公告)日：1992-06-23
申请号：US755913
申请日：1991-09-06
IPC分类号： C07C227/24 , C07C229/36 , C07D233/78
CPC分类号： C07C229/36 , C07C227/24 , C07D233/78
摘要： Substituted phenethanol ethers are prepared by the catalytic reduction of corresponding substituted phenylglyoxal acetals. The catalytic reduction is carried out by reacting a substituted phenylglyoxal acetal with hydrogen in the presence of an acid catalyst and a metal catalyst. Certain substituted phenylglyoxal acetals, and more particularly, 4-hydroxyphenylglyoxal dialkyl acetals are prepared by reacting 4-hydroxyacetophenone with a primary or a secondary alkyl alcohol in the presence of a hydrogen ion (H+) source and a nitrosonium ion (NO+) source.
摘要翻译： 取代的苯乙醇醚通过相应的取代的苯乙醛缩醛的催化还原制备。 催化还原通过在酸催化剂和金属催化剂存在下使取代的苯乙醛缩醛与氢反应来进行。 通过在氢离子（H +）源和亚硝鎓离子（NO +）源的存在下使4-羟基苯乙酮与伯或仲烷基醇反应来制备某些取代的苯乙醛缩醛，更具体地，4-羟基苯基乙二醛二烷基缩醛。
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公开(公告)号：US5041657A
公开(公告)日：1991-08-20
申请号：US555277
申请日：1990-07-19
申请人： Graham N. Mott
发明人： Graham N. Mott
IPC分类号： C07C231/10 , C07C235/34
CPC分类号： C07C231/10
摘要： A method is provided for preparing aromatic acetamides comprising reacting an aryl methyl ketone containing the same number of carbon atoms as the aromatic acetamide, with sulfur and ammonia under substantially anhydrous conditions. The method is particularly useful for the preparation of 4-hydroxyphenylacetamide from 4-hydroxyacetophenone.
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公开(公告)号：US5498804A
公开(公告)日：1996-03-12
申请号：US406266
申请日：1995-03-17
IPC分类号： C07C29/145 , C07C37/00 , C07C39/10
CPC分类号： C07C37/002 , Y02P20/582
摘要： The present invention provides a unique and novel way of producing carbinols such as 4-hydroxyphenylmethylcarbinol (HPMC). In this new process, a ketone such as 4-hydroxyacetophenone (4-HAP) is heated under suitable hydrogenation conditions of temperature and pressure in the presence of a suitable catalyst and for a sufficient period of time to form HPMC.
摘要翻译： 本发明提供了一种独特且新颖的生产甲醇的方法，如4-羟基苯基甲基甲醇（HPMC）。 在该新方法中，在合适的催化剂存在下，在合适的温度和压力的氢化条件下加热酮如4-羟基苯乙酮（4-HAP）并持续足够的时间以形成HPMC。
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公开(公告)号：US5453483A
公开(公告)日：1995-09-26
申请号：US406350
申请日：1995-03-17
CPC分类号： C08F12/24 , C08F8/00 , Y02P20/582
摘要： The present invention provides a unique and novel way of producing vinyl phenols such as poly(4-hydroxystyrene) (PHS). In this new process, 4-hydroxyphenylmethylcarbinol (HPMC) is heated under suitable conditions of temperature and pressure and for a sufficient period of time to form the poly (4-hydroxystyrene) (PHS).
摘要翻译： 本发明提供了一种独特且新颖的生产乙烯基苯酚的方法，如聚（4-羟基苯乙烯）（PHS）。 在该新方法中，在合适的温度和压力条件下加热4-羟基苯基甲基甲醇（HPMC）足够长的时间以形成聚（4-羟基苯乙烯）（PHS）。
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