USE OF INTERLEUKIN 17E FOR THE TREATMENT OF CANCER
    1.
    发明申请
    USE OF INTERLEUKIN 17E FOR THE TREATMENT OF CANCER 失效
    使用白细胞介素17E治疗癌症

    公开(公告)号:US20110158936A1

    公开(公告)日:2011-06-30

    申请号:US11817914

    申请日:2006-03-08

    摘要: The use of interleukin 17E to inhibit tumour growth in a subject is provided. The interleukin 17E can be provided to the subject exogenously, as an interleukin 17E polypeptide or a polynucleotide encoding an interleukin 17E polypeptide, or it can be provided by stimulating production of endogenous interleukin 17E. Also provided is the use of interleukin 17E in combination with one or more anti-cancer therapeutics for inhibiting tumour growth in a subject. Anti-cancer therapeutics include, for example, standard chemotherapeutic drugs, immunotherapeutics, radiation, gene therapy, hormone manipulation and antisense therapy.

    摘要翻译: 提供了白细胞介素17E在受试者中抑制肿瘤生长的用途。 作为白细胞介素17E多肽或编码白细胞介素17E多肽的多核苷酸,可以外源性地向受试者提供白细胞介素17E,或者可以通过刺激内源白细胞介素17E的产生来提供白细胞介素17E。 还提供了白细胞介素17E与一种或多种抗癌治疗剂组合用于抑制受试者中的肿瘤生长的用途。 抗癌疗法包括例如标准化学治疗药物,免疫治疗剂,辐射,基因治疗,激素操作和反义治疗。

    Use of interleukin 17E for the treatment of cancer
    4.
    发明授权
    Use of interleukin 17E for the treatment of cancer 失效
    使用白介素17E治疗癌症

    公开(公告)号:US08287851B2

    公开(公告)日:2012-10-16

    申请号:US11817914

    申请日:2006-03-08

    IPC分类号: A61K38/20

    摘要: The use of interleukin 17E to inhibit tumor growth in a subject is provided. The interleukin 17E can be provided to the subject exogenously, as an interleukin 17E polypeptide or a polynucleotide encoding an interleukin 17E polypeptide, or it can be provided by stimulating production of endogenous interleukin 17E. Also provided is the use of interleukin 17E in combination with one or more anti-cancer therapeutics for inhibiting tumor growth in a subject. Anti-cancer therapeutics include, for example, standard chemotherapeutic drugs, immunotherapeutics, radiation, gene therapy, hormone manipulation and antisense therapy.

    摘要翻译: 提供了白细胞介素17E在受试者中抑制肿瘤生长的用途。 作为白细胞介素17E多肽或编码白细胞介素17E多肽的多核苷酸,可以外源性地向受试者提供白细胞介素17E,或者可以通过刺激内源白细胞介素17E的产生来提供白细胞介素17E。 还提供了白细胞介素17E与一种或多种抗癌治疗剂组合用于抑制受试者中的肿瘤生长的用途。 抗癌疗法包括例如标准化学治疗药物,免疫治疗剂,辐射,基因治疗,激素操作和反义治疗。

    2-Indolyl Imidazo [4,5-d] Phenanthroline Derivatives and Their Use in the Treatment for Cancer
    5.
    发明申请
    2-Indolyl Imidazo [4,5-d] Phenanthroline Derivatives and Their Use in the Treatment for Cancer 有权
    2-吲哚咪唑并[4,5-d]菲咯啉衍生物及其在癌症治疗中的应用

    公开(公告)号:US20100168417A1

    公开(公告)日:2010-07-01

    申请号:US11915257

    申请日:2006-05-25

    CPC分类号: C07D471/14

    摘要: 2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula I that are capable of intracellular chelation of transition metals and of exerting antiproliferative effects in cancer cells, that are cytostatic and/or cytotoxic, are provided. Compounds of Formula I can also induce apoptosis in cancer cells and are thus capable of exerting a cytotoxic effect on cancer cells. The compounds of Formula I are also capable of selectively inhibiting the proliferation of one or more of prostate cancer cells, colon cancer cells, non-small lung cancer cells and leukemia cells. The compounds of Formula I are also capable of increasing the expression of the zinc-regulated tumour suppressor, KLF4 and thus are useful in inhibiting the proliferation of cancer cells in which KLF4 functions as a tumour-suppressor, including, but not limited to, bladder cancer, cancers of the gastrointestinal tract and various leukemias.

    摘要翻译: 提供能够细胞内螯合过渡金属并且在细胞抑制和/或细胞毒性的癌细胞中发挥抗增殖作用的式I的2-吲哚基咪唑并[4,5-d]菲咯啉化合物。 式I的化合物还可以诱导癌细胞凋亡,因此能够对癌细胞发挥细胞毒性作用。 式I的化合物还能够选择性地抑制一种或多种前列腺癌细胞,结肠癌细胞,非小细胞肺癌细胞和白血病细胞的增殖。 式I的化合物还能够增加锌调节的肿瘤抑制因子KLF4的表达,因此可用于抑制KLF4作为肿瘤抑制剂的癌细胞的增殖,包括但不限于膀胱 癌症,胃肠道癌症和各种白血病。

    Aryl imidazoles and their use as anti-cancer agents
    7.
    发明授权
    Aryl imidazoles and their use as anti-cancer agents 有权
    芳基咪唑及其作为抗癌剂的用途

    公开(公告)号:US08969372B2

    公开(公告)日:2015-03-03

    申请号:US10579149

    申请日:2004-11-15

    摘要: Therapeutically effective 2,4,5-trisubstituted imidazole compounds are provided. Also provided are methods of preparing the compounds and pharmaceutical compositions comprising the compounds alone or in combination with other agents. The present invention further provides for the use of the compounds as anti-cancer agents; wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl, substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3 when taken together along with the carbon atoms they are attached to, form aryl or substituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substituted lower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl, cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)0-2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl.

    摘要翻译: 提供了治疗上有效的2,4,5-三取代的咪唑化合物。 还提供了制备化合物和药物组合物的方法,其包含单独的化合物或与其它试剂组合。 本发明还提供了化合物作为抗癌剂的用途; 其中:R1是芳基,取代的芳基,杂环,取代的杂环,杂芳基,取代的杂芳基或氨基; R2和R3独立地是芳基,取代的芳基,杂环,杂芳基,取代的杂环或取代的杂芳基,或者当R 2和R 3与它们连接的碳原子一起形成时,R 2和R 3,形成芳基或取代的芳基,且R 4是氢,卤素, 羟基,硫醇,低级烷基,取代的低级烷基,低级烯基,取代的低级烯基,低级炔基,取代的低级炔基,烷基烯基,烷基炔基,烷氧基,烷硫基,芳基,芳氧基,氨基,酰胺基,羧基,芳基,取代的芳基,杂环 ,杂芳基,取代的杂环,杂烷基,环烷基,取代的环烷基,烷基环烷基,烷基环杂烷基,硝基,氰基或-S(O)0-2R,其中R是烷基,取代的烷基,芳基,取代的芳基,杂环,杂芳基,取代的杂环或 取代的杂芳基。

    Plasma display panel
    8.
    发明申请
    Plasma display panel 审中-公开
    等离子显示面板

    公开(公告)号:US20070007871A1

    公开(公告)日:2007-01-11

    申请号:US11480563

    申请日:2006-07-05

    申请人: Yoon Lee

    发明人: Yoon Lee

    IPC分类号: H01J17/49 H01J1/88

    摘要: Disclosed herein is a plasma display panel. The plasma display panel comprises partition walls between first and second substrates to separate discharge cells from each other. Each of the partition walls comprises a non-Pb based glass powder matrix, and a non-Pb based filler having a ratio of 5˜45 wt % with respect to the glass powder matrix.

    摘要翻译: 本文公开了等离子体显示面板。 等离子体显示面板包括在第一和第二基板之间的分隔壁,以将放电单元彼此分开。 每个分隔壁包括非Pb基玻璃粉末基质和相对于玻璃粉末基质具有5〜45重量%的比例的非Pb基填料。

    Non-crystalline cellulose and production thereof
    9.
    发明申请
    Non-crystalline cellulose and production thereof 审中-公开
    非结晶纤维素及其生产

    公开(公告)号:US20050272926A1

    公开(公告)日:2005-12-08

    申请号:US11142936

    申请日:2005-06-02

    申请人: Yoon Lee Hatem Harraz

    发明人: Yoon Lee Hatem Harraz

    CPC分类号: C08H8/00 C08B1/00 C08B15/02

    摘要: A non crystalline or low crystallinity cellulose. A method of making a non crystalline or low crystallinity cellulose comprising providing cellulosic material, adding an effective acid in an amount effective to at least wet the cellulosic material, mixing the cellulosic material and acid under conditions effective to form an essentially uniformly wet condition, letting the mixture sit at ambient conditions for a period of time sufficient to form a viscous fluid, adding water or other diluent in an amount sufficient to lower the acid concentration and to form a slurry, dewatering the slurry, and removing any residual acid from the dewatered slurry.

    摘要翻译: 非结晶或低结晶度纤维素。 一种制造非结晶或低结晶度纤维素的方法,包括提供纤维素材料,加入有效量至少能使纤维素材料湿润的有效酸,将纤维素材料和酸在有效形成基本上均匀湿润的条件下混合,让 混合物在环境条件下保持一段足以形成粘性流体的时间,加入足以降低酸浓度并形成浆料的量的水或其它稀释剂,使浆液脱水,并从脱水物中除去任何残留的酸 泥浆。

    METHOD AND SYSTEM FOR PROVIDING COMMODITY INFORMATION IN SHOPPING COMMODITY SEARCHING SERVICE
    10.
    发明申请
    METHOD AND SYSTEM FOR PROVIDING COMMODITY INFORMATION IN SHOPPING COMMODITY SEARCHING SERVICE 有权
    在商店搜索服务中提供商品信息的方法和系统

    公开(公告)号:US20070100709A1

    公开(公告)日:2007-05-03

    申请号:US11552508

    申请日:2006-10-24

    IPC分类号: G06Q30/00

    摘要: A method and system for providing product information, which can retrieve an advertising shopping mall that has suggested a bidding price for an upper display area, and can sort product information of the retrieved advertising shopping mall according to a predetermined standard, and display the sorted product information in the upper display area and also can sort product information according to various types of standards, such as a popularity, a sales volume, and the like, and display the sorted product information in a remaining area excluding the upper display area, when sorting and displaying product information on a product search result page.

    摘要翻译: 一种用于提供产品信息的方法和系统,其可以检索已经建议了用于上部显示区域的投标价格的广告购物中心,并且可以根据预定标准对所检索的广告商场的商品信息进行分类,并且显示排序的商品 信息在上部显示区域中,并且还可以根据各种类型的标准(例如流行度,销售量等)对产品信息进行分类,并且在排序时将排序的产品信息显示在除了上显示区域之外的剩余区域中 并在产品搜索结果页面上显示产品信息。