公开(公告)号：US4897470A

公开(公告)日：1990-01-30

申请号：US34879

申请日：1987-04-06

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa, deceased

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa, deceased

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12P29/00 ,  C12R1/465

CPC分类号： C07H15/252

摘要： New anthracycline antibiotics of a formula (I) are provided, which are usable as an anticancer agent ##STR1## (where R represents a hydrogen atom or a hydroxyl group). The antibiotics (I) can be produced by incubation of a dye-nonproductive or hardly dye-productive mutant strain which has an ability of converting .alpha.-citromycinone or .beta.-isorhodomycinone into the antibiotics (I), in the presence of .alpha.-citromycinone or .beta.-isorhodomycinone in a pertinent nutrient medium.

公开(公告)号：US4734493A

公开(公告)日：1988-03-29

申请号：US849229

申请日：1986-04-07

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/04 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24

CPC分类号： C07H15/252

摘要： The antibiotics designated obelmycins exhibit high proliferation inhibiting action against leukemia cells and are effective as anti-cancer agents.

摘要翻译： 称为替米yc嗪的抗生素对白血病细胞表现出高增殖抑制作用，作为抗癌剂是有效的。

公开(公告)号：US4918172A

公开(公告)日：1990-04-17

申请号：US252636

申请日：1988-10-03

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomoyuki Ishikura ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Tomio Takeuchi

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomoyuki Ishikura ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Tomio Takeuchi

IPC分类号： C07H15/252

CPC分类号： C07H15/252

摘要： Disclosed are anthracycline antibiotics of a formula (I): ##STR1## in which R.sup.1 and R.sup.2 are hydroxyl groups, R.sup.3 is ethyl group, R.sup.4 is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1 and R.sup.2 are hydroxyl groups, R.sup.3 is 1-hydroxyethyl group, R.sup.4 is hydrogen atom and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1, R.sup.2 and R.sup.4 are hydroxyl groups, R.sup.3 is ethyl group and X represents daunosamine-rhodenose, daunosamine-deoxyfucose, rhodosamine-rhodenose, N-monomethyldaunosamine-rhodenose or N-monomethyldaunosamine-deoxyfucose; orR.sup.1 is methoxy group, R.sup.2 is hydroxyl group, R.sup.3 is ethyl group, R.sup.4 is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1 and R.sup.4 are hydroxy groups, R.sup.2 is hydrogen atom, R.sup.3 is ethyl group and X represents daunosamine-deoxyfucose, as well as pharmaceutically acceptable acid addition salts thereof. The antibiotics (I) have a carcinostatic activity and are useful as a carcinostatic for murine leukemia L1210 cells in culture.

公开(公告)号：US4954438A

公开(公告)日：1990-09-04

申请号：US397061

申请日：1989-08-21

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomio Takeuchi

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomio Takeuchi

IPC分类号： C12P19/56 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12R1/465

CPC分类号： C07H15/252 ,  Y10S435/886

摘要： This invention relates to a process for preparing an antibiotic D788-7 wherein, after culturing carborubicin-producing bacteria, the obtained culture liquid is extracted in acidic conditions while stirring to be absorbed to synthetic resin, followed by desorption from the resin and elution with acetone and the resulting acetone solution containing carborubicin is converted into an antibiotic D788-7 by photo radiation, for obtaining D788-7 in the purified form from the reaction solution. The production yield for D788-7 is extremely high and its use as an antitumor agent can be made possible.