公开(公告)号：US4734493A

公开(公告)日：1988-03-29

申请号：US849229

申请日：1986-04-07

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/04 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24

CPC分类号： C07H15/252

摘要： The antibiotics designated obelmycins exhibit high proliferation inhibiting action against leukemia cells and are effective as anti-cancer agents.

摘要翻译： 称为替米yc嗪的抗生素对白血病细胞表现出高增殖抑制作用，作为抗癌剂是有效的。

公开(公告)号：US4897470A

公开(公告)日：1990-01-30

申请号：US34879

申请日：1987-04-06

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa, deceased

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa, deceased

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12P29/00 ,  C12R1/465

CPC分类号： C07H15/252

摘要： New anthracycline antibiotics of a formula (I) are provided, which are usable as an anticancer agent ##STR1## (where R represents a hydrogen atom or a hydroxyl group). The antibiotics (I) can be produced by incubation of a dye-nonproductive or hardly dye-productive mutant strain which has an ability of converting .alpha.-citromycinone or .beta.-isorhodomycinone into the antibiotics (I), in the presence of .alpha.-citromycinone or .beta.-isorhodomycinone in a pertinent nutrient medium.

公开(公告)号：US4918172A

公开(公告)日：1990-04-17

申请号：US252636

申请日：1988-10-03

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomoyuki Ishikura ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Tomio Takeuchi

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomoyuki Ishikura ,  Hiroshi Naganawa ,  Tsutomu Sawa ,  Tomio Takeuchi

IPC分类号： C07H15/252

CPC分类号： C07H15/252

摘要： Disclosed are anthracycline antibiotics of a formula (I): ##STR1## in which R.sup.1 and R.sup.2 are hydroxyl groups, R.sup.3 is ethyl group, R.sup.4 is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1 and R.sup.2 are hydroxyl groups, R.sup.3 is 1-hydroxyethyl group, R.sup.4 is hydrogen atom and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1, R.sup.2 and R.sup.4 are hydroxyl groups, R.sup.3 is ethyl group and X represents daunosamine-rhodenose, daunosamine-deoxyfucose, rhodosamine-rhodenose, N-monomethyldaunosamine-rhodenose or N-monomethyldaunosamine-deoxyfucose; orR.sup.1 is methoxy group, R.sup.2 is hydroxyl group, R.sup.3 is ethyl group, R.sup.4 is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; orR.sup.1 and R.sup.4 are hydroxy groups, R.sup.2 is hydrogen atom, R.sup.3 is ethyl group and X represents daunosamine-deoxyfucose, as well as pharmaceutically acceptable acid addition salts thereof. The antibiotics (I) have a carcinostatic activity and are useful as a carcinostatic for murine leukemia L1210 cells in culture.

公开(公告)号：US4612371A

公开(公告)日：1986-09-16

申请号：US756876

申请日：1985-07-18

申请人： Akihiro Yoshimoto ,  Shizuka Fujii ,  Katsuro Kubo ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa

发明人： Akihiro Yoshimoto ,  Shizuka Fujii ,  Katsuro Kubo ,  Tomoyuki Ishikura ,  Tsutomu Sawa ,  Tomio Takeuchi ,  Hamao Umezawa

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24

CPC分类号： C07H15/252

摘要： Novel anthracycline antibiotics characteristic of Ring A of the anthracycline skeleton are produced by microorganisms belonging to the genus Streptomyces and are useful as anti-cancer agents. The antibiotics designated D-788-6 to -10 are shown by general formula: ##STR1## wherein Y represents a group shown by: ##STR2##

摘要翻译： 蒽环霉素骨架A环特征的新型蒽环类抗生素由属于链霉菌属的微生物产生，可用作抗癌剂。 称为D-788-6至-10的抗生素由以下通式表示：其中Y代表如下所示的基团：

公开(公告)号：US4592999A

公开(公告)日：1986-06-03

申请号：US514678

申请日：1983-07-18

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Kageaki Kouno ,  Tomoyuki Ishikura ,  Akihiro Yoshimoto ,  Yukio Takatsuki ,  Hiroyasu Tobe

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Kageaki Kouno ,  Tomoyuki Ishikura ,  Akihiro Yoshimoto ,  Yukio Takatsuki ,  Hiroyasu Tobe

IPC分类号： C12P17/06 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465

CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  Y10S435/886

摘要： This invention is to provide a new microbial process for producing daunomycin by a mutant strain belonging to the genus Streptomyces.

摘要翻译： 本发明提供一种用于通过属于链霉菌属的突变菌株生产道诺霉素的新的微生物方法。

公开(公告)号：US4424342A

公开(公告)日：1984-01-03

申请号：US361175

申请日：1982-03-24

申请人： Toshikazu Oki ,  Akihiro Yoshimoto ,  Yasue Matsuzawa ,  Tomoyuki Ishikura ,  Hamao Umezawa ,  Tomio Takeuchi

发明人： Toshikazu Oki ,  Akihiro Yoshimoto ,  Yasue Matsuzawa ,  Tomoyuki Ishikura ,  Hamao Umezawa ,  Tomio Takeuchi

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24 ,  A61K31/71

CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465

摘要： Disclosed are an antitumor compound having the chemical structure ##STR1## or its acid addition salts; and its preparation method which consists of treating a compound represented by the chemical structure ##STR2## wherein R is a COCH.sub.3 or CH(OH)CH.sub.3 group, by a streptomycetes strain or its mutants.

摘要翻译： 公开了具有化学结构（I）或其酸加成盐的抗肿瘤化合物; 及其制备方法，该方法由化学结构（IMAGE）（II）表示的化合物

公开(公告)号：US4439603A

公开(公告)日：1984-03-27

申请号：US436630

申请日：1982-10-25

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Tomoyuki Ishikura ,  Akihiro Yoshimoto ,  Yasue Matsuzawa ,  Yukio Takatsuki

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Tomoyuki Ishikura ,  Akihiro Yoshimoto ,  Yasue Matsuzawa ,  Yukio Takatsuki

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C07H15/24

CPC分类号： C07H15/252

摘要： New anthracycline derivatives, .beta.-rhodomycinone-RDA, .beta.-rhodomycinone-RDRs and .beta.-rhodomycinone-RD having potent anticancer activities and lower toxicities and a process for the production thereof by reduction or hydrolysis of .beta.-rhodomycinone-RDC are disclosed.

摘要翻译： 公开了新的蒽环类衍生物，β-近红霉素酮-RDA，β-霉菌酮-RDR和具有较强抗癌活性和较低毒性的β-二酮霉素-RR及其通过还原或水解β-维生素D-RDC生产的方法。

公开(公告)号：US4474945A

公开(公告)日：1984-10-02

申请号：US405917

申请日：1982-08-06

申请人： Akihiro Yoshimoto ,  Hiroyasu Tobe ,  Tomoyuki Ishikura ,  Hamao Umezawa ,  Tomio Takeuchi

发明人： Akihiro Yoshimoto ,  Hiroyasu Tobe ,  Tomoyuki Ishikura ,  Hamao Umezawa ,  Tomio Takeuchi

IPC分类号： C07H15/252 ,  C12P19/56 ,  C07H17/08 ,  C12N1/00 ,  C12P19/62

CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  Y10S514/908

摘要： New anthracycline compounds, 2-hydroxyaclacinomycin B having potent antitumor activity and lower toxicity, and a process for producing 2-hydroxyaclacinomycins A, B, and N by fermentation.

摘要翻译： 新的蒽环类化合物，具有有效抗肿瘤活性和较低毒性的2-羟基阿拉伯霉素B，以及通过发酵生产2-羟基卡曲霉素A，B和N的方法。

公开(公告)号：US4954438A

公开(公告)日：1990-09-04

申请号：US397061

申请日：1989-08-21

申请人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomio Takeuchi

发明人： Akihiro Yoshimoto ,  Osamu Jodo ,  Yoshio Watanabe ,  Rokuro Okamoto ,  Tomio Takeuchi

IPC分类号： C12P19/56 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P35/00 ,  C07H15/252 ,  C12R1/465

CPC分类号： C07H15/252 ,  Y10S435/886

摘要： This invention relates to a process for preparing an antibiotic D788-7 wherein, after culturing carborubicin-producing bacteria, the obtained culture liquid is extracted in acidic conditions while stirring to be absorbed to synthetic resin, followed by desorption from the resin and elution with acetone and the resulting acetone solution containing carborubicin is converted into an antibiotic D788-7 by photo radiation, for obtaining D788-7 in the purified form from the reaction solution. The production yield for D788-7 is extremely high and its use as an antitumor agent can be made possible.

公开(公告)号：US4316011A

公开(公告)日：1982-02-16

申请号：US164756

申请日：1980-06-30

申请人： Toshikazu Oki ,  Akihiro Yoshimoto ,  Yasue Matsuzawa ,  Taiji Inui ,  Tomio Takeuchi ,  Hamao Umezawa

发明人： Toshikazu Oki ,  Akihiro Yoshimoto ,  Yasue Matsuzawa ,  Taiji Inui ,  Tomio Takeuchi ,  Hamao Umezawa

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/04 ,  C07H15/252 ,  C12P19/56 ,  C12R1/465 ,  C07H15/24 ,  A61K31/71

CPC分类号： C07H15/252 ,  C12P19/56 ,  C12R1/465

摘要： New anthracycline glycoside derivatives of rhodomycin-group, .epsilon.-rhodomycin RDC, .epsilon.-isorhodomycin RDC, .beta.-rhodomycin RDC, .gamma.-rhodomycin RDC, .gamma.-rhodomycin RDRs and .beta.-pyrromycin RDC having potent anticancer activities and lower toxicities and a process for the production thereof by microbiological conversion method are disclosed.

摘要翻译： 罗丹霉素组的新蒽环苷类衍生物，ε-罗红霉素RDC，ε-异亮霉素RDC，β-霉菌素RDC，γ-霉素RDC，γ-霉素RDR和β-吡咯霉素RDC具有很强的抗癌活性和较低的毒性， 公开了通过微生物转化方法的生产。