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公开(公告)号：US08221769B2
公开(公告)日：2012-07-17
申请号：US12589694
申请日：2009-10-26
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K39/385 , A61K39/12
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以导致其中积聚的细胞的泄漏的细胞膜，导致产生对蛋白质和其他细胞产物具有反应性的抗体，并且还允许开发促进增殖的组织，特别是肿瘤，以产生选定的蛋白质等 产品。 提供含有微生物的疫苗。 还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。
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公开(公告)号：US08021662B2
公开(公告)日：2011-09-20
申请号：US11796027
申请日：2007-04-25
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/395 , A61K39/12 , A61K39/275 , C12P21/00 , C12Q1/66 , A61K39/285
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Methods for production of tumor-specific antibodies are provided. The methods employ microorganisms that are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products.
摘要翻译： 提供了生产肿瘤特异性抗体的方法。 与其他组织，细胞和器官相比，这些方法使用设计成在免疫缺陷组织和细胞中积累的微生物，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有较低的毒性。 微生物也被设计或修饰以产生它们积聚的细胞的泄漏的细胞膜，导致生成对蛋白质和其它细胞产物具有反应性的抗体，并且还允许利用增殖组织，特别是肿瘤来产生选定的蛋白质和其它产物 。
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公开(公告)号：US20100008946A1
公开(公告)日：2010-01-14
申请号：US12462074
申请日：2009-07-28
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
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公开(公告)号：US07588771B2
公开(公告)日：2009-09-15
申请号：US11238025
申请日：2005-09-27
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K39/385 , A61K39/12 , A61K39/20
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以产生它们积聚的细胞的泄漏的细胞膜，导致生成对蛋白质和其它细胞产物具有反应性的抗体，并且还允许利用增殖组织，特别是肿瘤来产生选定的蛋白质和其它产物 。 提供含有微生物的疫苗。 还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。
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公开(公告)号：US20120276010A1
公开(公告)日：2012-11-01
申请号：US13507572
申请日：2012-07-10
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和痘苗病毒。 这些病毒被设计成与其他组织，细胞和器官相比，它们在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有较低的毒性。 还提供了病毒和抗癌剂的组合及其用于治疗癌症的用途。
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公开(公告)号：US07662398B2
公开(公告)日：2010-02-16
申请号：US11529662
申请日：2006-09-27
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K39/385 , A61K39/12 , A01N65/00 , A61K39/20
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以产生它们积聚的细胞的泄漏的细胞膜，导致生成对蛋白质和其它细胞产物具有反应性的抗体，并且还允许利用增殖组织，特别是肿瘤来产生选定的蛋白质和其它产物 。 提供含有微生物的疫苗。 还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。
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公开(公告)号：US07588767B2
公开(公告)日：2009-09-15
申请号：US10872156
申请日：2004-06-18
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A01N63/00 , A61K39/12 , A61K39/275 , A61K39/00 , G01N33/574 , A61K39/145
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefore are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Methods for making tumor specific antibodies and also methods of making gene products encoded by the microorganism as well as antibodies reactive therewith are provided.
摘要翻译： 因此提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以产生它们积聚的细胞的泄漏的细胞膜，导致生成对蛋白质和其它细胞产物具有反应性的抗体，并且还允许利用增殖组织，特别是肿瘤来产生选定的蛋白质和其它产物 。 提供了制备肿瘤特异性抗体的方法以及由微生物编码的基因产物以及与其反应的抗体的方法。
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公开(公告)号：US20140294891A1
公开(公告)日：2014-10-02
申请号：US14301813
申请日：2014-06-11
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided
摘要翻译： 提供了治疗方法和痘苗病毒。 这些病毒被设计成与其他组织，细胞和器官相比，它们在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有较低的毒性。 还提供了病毒和抗癌剂的组合及其用于治疗癌症的用途
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公开(公告)号：US08784836B2
公开(公告)日：2014-07-22
申请号：US13507572
申请日：2012-07-10
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A01N63/00 , A61K39/12 , A61K39/275 , A61K39/00 , G01N33/574 , A61K39/145
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and vaccinia virus therefor are provided. The viruses are designed so that they accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. Combinations of the viruses and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和痘苗病毒。 这些病毒被设计成与其他组织，细胞和器官相比，它们在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有较低的毒性。 还提供了病毒和抗癌剂的组合及其用于治疗癌症的用途。
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公开(公告)号：US20110300176A1
公开(公告)日：2011-12-08
申请号：US12148542
申请日：2008-04-17
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61P35/00 , C12N7/01
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以导致其中积聚的细胞的泄漏的细胞膜，导致产生对蛋白质和其他细胞产物具有反应性的抗体，并且还允许开发促进增殖的组织，特别是肿瘤，以产生选定的蛋白质等 产品。 提供含有微生物的疫苗。 还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。
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