公开(公告)号：US11642051B2

公开(公告)日：2023-05-09

申请号：US16777851

申请日：2020-01-30

申请人： Benjamin Mbouombouo ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Kevin Hazen

发明人： Benjamin Mbouombouo ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  G01N33/49 ,  G01J3/10

CPC分类号： A61B5/1455 ,  A61B5/0022 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/14532 ,  A61B5/6824 ,  A61B5/6832 ,  G01J3/10 ,  G01N33/49 ,  A61B5/0004 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/046 ,  G01J2003/102 ,  G01J2003/106

摘要： The invention comprises a method and apparatus for sampling a common tissue volume and/or a common skin layer skin of a person as a part of noninvasive analyte property determination system, comprising the steps of: providing an analyzer, comprising at least three detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including a first and second range of detection zones of differing radial distances from a first illumination zone and second illumination zone, respectively coupled to separate sources; repetitively illuminating the illumination zones of the skin with photons in a range of 1200 to 2500 nm; and detecting portions of light from the sources with the at least three detectors, the detectors positioned on a common line with the sources.

公开(公告)号：US11633130B2

公开(公告)日：2023-04-25

申请号：US16691611

申请日：2019-11-22

申请人： Alodeep Sanyal ,  Benjamin Mbouombouo ,  Roxanne Abul-Haj ,  Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen

发明人： Alodeep Sanyal ,  Benjamin Mbouombouo ,  Roxanne Abul-Haj ,  Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/145 ,  A61B5/00 ,  G01J3/00

摘要： The invention comprises a method and apparatus for noninvasively determining state of a person, comprising the steps of: providing an analyzer comprising a first and second spectrometer unit and a main controller subsystem; replaceably attaching the first spectrometer unit to the person at a first illumination zone; the first spectrometer unit delivering first photons, from first illumination optics, along a first mean z-axis optical path normal to a first x/y-plane tangentially contacting the first illumination zone of the person; replaceably attaching a second spectrometer unit to the person at a second illumination zone; the second spectrometer delivering second photons, from second illumination optics, along a second mean z-axis optical path perpendicular to a second x/y-plane tangentially contacting the second illumination zone of the skin, the first x/y-plane noncoplanar with the second x/y-plane; and the main controller processing detected signals to generate at least one measure of state of the person.

公开(公告)号：US20200337603A1

公开(公告)日：2020-10-29

申请号：US16777855

申请日：2020-01-30

申请人： Kevin Hazen ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Benjamin Mbouombouo

发明人： Kevin Hazen ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Benjamin Mbouombouo

IPC分类号： A61B5/1455 ,  G01N33/49 ,  A61B5/00 ,  A61B5/145

摘要： The invention comprises a method and apparatus for sampling a common tissue volume and/or a common skin layer skin of a person as a part of noninvasively determining an analyte property with an analyzer including: a set of detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including a first and second range of detection zones of differing radial distances from a first illumination zone and second illumination zone, respectively coupled to separate sources, with surface paths between the sources and detectors overlapping a common skin area during use.

公开(公告)号：US20200337612A1

公开(公告)日：2020-10-29

申请号：US16777832

申请日：2020-01-30

申请人： Roxanne Abul-Haj ,  Kevin Hazen ,  Christopher Slawinski ,  Benjamin Mbouombouo ,  Alodeep Sanyal ,  Alan Abul-Haj

发明人： Roxanne Abul-Haj ,  Kevin Hazen ,  Christopher Slawinski ,  Benjamin Mbouombouo ,  Alodeep Sanyal ,  Alan Abul-Haj

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455

摘要： The invention comprises a method and apparatus for sampling optical pathways having a common tissue depth, such as a maximum mean depth of penetration in the dermis, with a common detector of a person for analysis in a noninvasive analyte property determination system, comprising the steps of: probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges, which optionally overlap, and detecting, using a common detector, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection.

公开(公告)号：US20200337611A1

公开(公告)日：2020-10-29

申请号：US16777827

申请日：2020-01-30

申请人： Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen ,  Roxanne Abul-Haj ,  Benjamin Mbouombouo ,  Alodeep Sanyal

发明人： Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen ,  Roxanne Abul-Haj ,  Benjamin Mbouombouo ,  Alodeep Sanyal

IPC分类号： A61B5/145 ,  A61B5/1455 ,  A61B5/00

摘要： The invention comprises a method and apparatus for selecting optical pathways sampling a common tissue layer, such as the dermis, of a person for analysis in a noninvasive analyte property determination systemy, comprising the steps of:probing skin with a range of illumination zone-to-detection zone distances with at least two wavelength ranges, which optionally overlap, and selecting, using a metric, illumination zone-to-detection zone distances having mean optical pathways probing the common tissue layer, such as without the mean optical pathways entering the subcutaneous fat layer of the person. Optionally, the skin tissue layers are modulated and/or treated via tissue displacement before and/or during data collection.

公开(公告)号：US20200337602A1

公开(公告)日：2020-10-29

申请号：US16777851

申请日：2020-01-30

申请人： Benjamin Mbouombouo ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Kevin Hazen

发明人： Benjamin Mbouombouo ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  G01N33/49 ,  A61B5/00 ,  A61B5/145

摘要： The invention comprises a method and apparatus for sampling a common tissue volume and/or a common skin layer skin of a person as a part of noninvasive analyte property determination system, comprising the steps of: providing an analyzer, comprising at least three detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including a first and second range of detection zones of differing radial distances from a first illumination zone and second illumination zone, respectively coupled to separate sources; repetitively illuminating the illumination zones of the skin with photons in a range of 1200 to 2500 nm; and detecting portions of light from the sources with the at least three detectors, the detectors positioned on a common line with the sources.

公开(公告)号：US20200085352A1

公开(公告)日：2020-03-19

申请号：US16691611

申请日：2019-11-22

申请人： Alodeep Sanyal ,  Benjamin Mbouombouo ,  Roxanne Abul-Haj ,  Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen

发明人： Alodeep Sanyal ,  Benjamin Mbouombouo ,  Roxanne Abul-Haj ,  Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen

IPC分类号： A61B5/145 ,  A61B5/1455 ,  A61B5/00

摘要： The invention comprises a method and apparatus for noninvasively determining state of a person, comprising the steps of: providing an analyzer comprising a first and second spectrometer unit and a main controller subsystem; replaceably attaching the first spectrometer unit to the person at a first illumination zone; the first spectrometer unit delivering first photons, from first illumination optics, along a first mean z-axis optical path normal to a first x/y-plane tangentially contacting the first illumination zone of the person; replaceably attaching a second spectrometer unit to the person at a second illumination zone; the second spectrometer delivering second photons, from second illumination optics, along a second mean z-axis optical path perpendicular to a second x/y-plane tangentially contacting the second illumination zone of the skin, the first x/y-plane noncoplanar with the second x/y-plane; and the main controller processing detected signals to generate at least one measure of state of the person.

公开(公告)号：US20200163596A1

公开(公告)日：2020-05-28

申请号：US16691615

申请日：2019-11-22

申请人： Alodeep Sanyal ,  Benjamin Mbouombouo ,  Roxanne Abul-Haj ,  Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen

发明人： Alodeep Sanyal ,  Benjamin Mbouombouo ,  Roxanne Abul-Haj ,  Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen

IPC分类号： A61B5/145 ,  A61B5/00

摘要： The invention comprises a method for noninvasively determining a sample property, comprising controlling photon generation from a source and analyzing signal from a set of detectors; irradiating an illumination zone of skin with the photons; and detecting diffusely reflected photons from the skin, the set of detectors respectively optically coupled to a set of detection zones of the skin positioned along a spiral path between a first and second radial distance from the illumination zone, where a first detection zone of a first detector of the set of detectors extends radially outward from the illumination zone to at least an inward radial distance, from the illumination zone, of a second detection zone of a second detector of the set of detectors, where at least one detection zone of the set of detection zones has a central radial distance from the illumination zone between the first and second radial distances.

公开(公告)号：US11690541B2

公开(公告)日：2023-07-04

申请号：US16777846

申请日：2020-01-30

申请人： Kevin Hazen ,  Benjamin Mbouombouo ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal

发明人： Kevin Hazen ,  Benjamin Mbouombouo ,  Alan Abul-Haj ,  Roxanne Abul-Haj ,  Christopher Slawinski ,  Alodeep Sanyal

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  G01N33/49 ,  G01J3/10

CPC分类号： A61B5/1455 ,  A61B5/0022 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/14532 ,  A61B5/6824 ,  A61B5/6832 ,  G01J3/10 ,  G01N33/49 ,  A61B5/0004 ,  A61B5/7264 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/046 ,  G01J2003/102 ,  G01J2003/106

摘要： The invention comprises a method and apparatus for sampling skin of a person as a part of noninvasive analyte property determination system, comprising the steps of: providing an analyzer, comprising: sources and at least three detectors at least partially embedded in a probe housing, the probe housing comprising a sample side surface, the detectors including: a range of differing radial distances from a first illumination zone; repetitively illuminating an illumination zone of the skin with photons in a range of 1200 to 2500 nm; detecting portions of the first photons with the at least three detectors; and using signals from the at least three detectors and a metric, respectively classifying the skin into a first, second, and third tissue state, the radial distances of the at least three detectors differing from each other by greater than ten percent.

公开(公告)号：US11547329B2

公开(公告)日：2023-01-10

申请号：US16691615

申请日：2019-11-22

申请人： Alodeep Sanyal ,  Benjamin Mbouombouo ,  Roxanne Abul-Haj ,  Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen

发明人： Alodeep Sanyal ,  Benjamin Mbouombouo ,  Roxanne Abul-Haj ,  Alan Abul-Haj ,  Christopher Slawinski ,  Kevin Hazen

IPC分类号： A61B5/1455 ,  A61B5/145 ,  A61B5/00 ,  G01J3/10

摘要： The invention comprises a method for noninvasively determining a sample property, comprising controlling photon generation from a source and analyzing signal from a set of detectors; irradiating an illumination zone of skin with the photons; and detecting diffusely reflected photons from the skin, the set of detectors respectively optically coupled to a set of detection zones of the skin positioned along a spiral path between a first and second radial distance from the illumination zone, where a first detection zone of a first detector of the set of detectors extends radially outward from the illumination zone to at least an inward radial distance, from the illumination zone, of a second detection zone of a second detector of the set of detectors, where at least one detection zone of the set of detection zones has a central radial distance from the illumination zone between the first and second radial distances.