公开(公告)号：US09827759B2

公开(公告)日：2017-11-28

申请号：US15246762

申请日：2016-08-25

申请人： Alan Doyle ,  Travis Softic ,  Kevin Ray

发明人： Alan Doyle ,  Travis Softic ,  Kevin Ray

IPC分类号： B41F7/00 ,  B41C1/10 ,  B41N1/00 ,  B41M1/08

CPC分类号： B41F7/00 ,  B41C1/1033 ,  B41C2201/02 ,  B41C2210/262 ,  B41M1/08 ,  B41N1/003

摘要： The blanket cylinder of a printing press is used to remove oleophobic debris from an imaged dry printing member. Following imaging—e.g., imagewise exposure of the printing member to radiation that ablates the layer below the oleophobic layer, or de-anchors it from the oleophobic layer without ablation—the printing member is brought into rolling contact with the blanket cylinder, and the press is operated “on impression.” This rolling contact may remove not only the oleophobic top layer but ablation debris of the underlying imaging layer as well.

公开(公告)号：US5653978A

公开(公告)日：1997-08-05

申请号：US470141

申请日：1995-06-06

申请人： Benjamin Arthur De Burgh Bradley ,  Alan Doyle ,  Belinda Mary Kumpel

发明人： Benjamin Arthur De Burgh Bradley ,  Alan Doyle ,  Belinda Mary Kumpel

IPC分类号： A61K38/00 ,  C07K16/34 ,  A61K39/395 ,  C12N5/22

CPC分类号： C07K16/34 ,  A61K38/00 ,  C07K2317/77

摘要： The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgG3 proteins; (c) having kappa light chains; (d) being of the allotype G3m(21); (e) binding to D.sup.u cells by an indirect antiglobulin test; (f) binding to D.sup.IV, D.sup.V and D.sup.VII variant antigens; and (g) not binding to D.sup.VI or D.sup.B variant antigens, which may be employed for Rh-typing of red blood cells and passive immunization to prevent hemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibody of cell line ECACC 87091606 deposited at the European Collection of Animal Cell Cultures, Public Health Laboratory Service Center for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4, OJG, England, on Sep. 16, 1987.

摘要翻译： 本发明提供具有以下基本特征的人单克隆抗体：（a）与Rh血型系统的Rh（D）抗原但不与C，c，E或e抗原结合; （b）为IgG3蛋白; （c）具有κ轻链; （d）是同型G3m（21）; （e）通过间接抗球蛋白试验与Du细胞结合; （f）与DIV，DV和DVII变体抗原的结合; 和（g）不与DVI或DB变体抗原结合，其可用于红细胞的Rh分型和被动免疫以预防新生儿的溶血性疾病。 这样的单克隆抗体的例子是保藏在European Collection of Animal Cell Cultures，Public Health Laboratory Service Center for Applied Microbiology and Research，Porton Down，Salisbury，Wiltshire，SP4，OJG，England的细胞系ECACC 87091606的单克隆抗体上， 1987年9月16日。

公开(公告)号：US5496548A

公开(公告)日：1996-03-05

申请号：US45244

申请日：1993-04-13

申请人： Benjamin A. De Burgh ,  Alan Doyle ,  Belinda M. Kumpel

发明人： Benjamin A. De Burgh ,  Alan Doyle ,  Belinda M. Kumpel

IPC分类号： A61K38/00 ,  C07K16/34 ,  A61K39/395 ,  C12N5/22 ,  G01N33/53

CPC分类号： C07K16/34 ,  A61K38/00 ,  C07K2317/77

摘要： The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgG3 proteins; (c) having kappa light chains; (d) being of the allotype G3m(21); (e) binding to D.sup.u cells by an indirect antiglobulin test; (f) binding to D.sup.IV, D.sup.V and D.sup.VII variant antigens; and (g) not binding to D.sup.VI or D.sup.B variant antigens, which may be employed for Rh-typing of red blood cells and passive immunization to prevent hemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibody of cell line ECACC 87091606 deposited at the European Collection of Animal Cell Cultures, Public Health Laboratory Service Center for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4, OJG, England of Sep. 16, 1987.

摘要翻译： 本发明提供具有以下基本特征的人单克隆抗体：（a）与Rh血型系统的Rh（D）抗原但不与C，c，E或e抗原结合; （b）为IgG3蛋白; （c）具有κ轻链; （d）是同型G3m（21）; （e）通过间接抗球蛋白试验与Du细胞结合; （f）与DIV，DV和DVII变体抗原的结合; 和（g）不与DVI或DB变体抗原结合，其可用于红细胞的Rh分型和被动免疫以预防新生儿的溶血性疾病。 这样的单克隆抗体的例子是保藏在European Collection of Animal Cell Cultures，Public Health Laboratory Service Center for Applied Microbiology and Research，Porton Down，Salisbury，Wiltshire，SP4，OJG，England of Sep的细胞系ECACC 87091606的单克隆抗体 1987年。

公开(公告)号：US5665356A

公开(公告)日：1997-09-09

申请号：US477552

申请日：1995-06-07

申请人： Benjamin Arthur De Burgh Bradley ,  Alan Doyle ,  Belinda Mary Kumpel

发明人： Benjamin Arthur De Burgh Bradley ,  Alan Doyle ,  Belinda Mary Kumpel

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P7/00 ,  A61P37/00 ,  C07K16/34 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/00 ,  G01N33/563 ,  G01N33/577 ,  C12N5/12

CPC分类号： C07K16/34 ,  A61K38/00 ,  C07K2317/732 ,  C07K2317/77

摘要： The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgG1 proteins; (c) having kappa light chains; (d) being Glm(3) or Glm(1,17) allotype; (e) binding to D.sup.u cells by an indirect antiglobulin test; (f) binding to D.sup.IV, D.sup.V and D.sup.VII variant antigens; and (g) not binding to D.sup.VI or D.sup.B variant antigens, which may be employed for Rh-typing of red blood cells and passive immunization to prevent hemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibodies of cell lines ECACC 87091605 and 87091604 deposited at the European Collection of Animal Cell Cultures, Public Health Laboratory Service Center for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4, OJG, England on Sep. 16, 1987.

摘要翻译： 本发明提供具有以下基本特征的人单克隆抗体：（a）与Rh血型系统的Rh（D）抗原但不与C，c，E或e抗原结合; （b）为IgG1蛋白; （c）具有κ轻链; （d）为Glm（3）或Glm（1,17）异型; （e）通过间接抗球蛋白试验与Du细胞结合; （f）与DIV，DV和DVII变体抗原的结合; 和（g）不与DVI或DB变体抗原结合，其可用于红细胞的Rh分型和被动免疫以预防新生儿的溶血性疾病。 这样的单克隆抗体的例子是保藏在欧洲动物细胞培养物公共卫生实验室，应用微生物学与研究公共卫生实验室服务中心，威尔特郡，索尔兹伯里，Porton Down的公开的ECACC 87091605和87091604的单克隆抗体，SP4，OJG，England 1987年9月16日。

公开(公告)号：US5487891A

公开(公告)日：1996-01-30

申请号：US57560

申请日：1993-05-06

申请人： Benjamin A. D. B. Bradley ,  Alan Doyle ,  Belinda M. Kumpel

发明人： Benjamin A. D. B. Bradley ,  Alan Doyle ,  Belinda M. Kumpel

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P7/00 ,  A61P37/00 ,  C07K16/34 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/00 ,  G01N33/563 ,  G01N33/577 ,  C12N5/22

CPC分类号： C07K16/34 ,  A61K38/00 ,  C07K2317/732 ,  C07K2317/77

摘要： The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgGl proteins; (c) having kappa light chains; (d) being Glm(3) or Glm(1,17) allotype; (e) binding to D.sup.u cells by an indirect antiglobulin test; (f) binding to D.sup.IV, D.sup.V and D.sup.VII variant antigens; and (g) not binding to D.sup.VI or D.sup.B variant antigens, which may be employed for Rh-typing of red blood cells and passive immunization to prevent hemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibodies of cell lines ECACC 87091605 and 87091604 deposited at the European Collection of Animal Cell Cultures, Public Health Laboratory Service Center for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4, OJG, England on 16th September 1987.

摘要翻译： 本发明提供具有以下基本特征的人单克隆抗体：（a）与Rh血型系统的Rh（D）抗原但不与C，c，E或e抗原结合; （b）为IgG1蛋白; （c）具有κ轻链; （d）为Glm（3）或Glm（1,17）异型; （e）通过间接抗球蛋白试验与Du细胞结合; （f）与DIV，DV和DVII变体抗原的结合; 和（g）不与DVI或DB变体抗原结合，其可用于红细胞的Rh分型和被动免疫以预防新生儿的溶血性疾病。 这样的单克隆抗体的例子是保藏在欧洲动物细胞培养物公共卫生实验室，应用微生物学与研究公共卫生实验室服务中心，威尔特郡，索尔兹伯里，Porton Down的公开的ECACC 87091605和87091604的单克隆抗体，SP4，OJG，England 1987年9月16日。