公开(公告)号：US06768925B2

公开(公告)日：2004-07-27

申请号：US10195455

申请日：2002-07-16

申请人： Alan J. Fenn ,  John Mon ,  Dennis Smith

发明人： Alan J. Fenn ,  John Mon ,  Dennis Smith

IPC分类号： A61F200

CPC分类号： A61N5/02

摘要： A method and apparatus that increases safety when employing externally focused adaptive phased array microwave thermotherapy (hyperthermia) for breast cancer treatment include microwave absorbing pads and metallic shielding to prevent undesired or stray surface tissue heating and to cushion the breast from mechanical pressure during breast compression. The microwave absorbing pads are attached on the top of the microwave waveguide thermotherapy applicators and on top of the breast compression paddles. A metallic-shielding strip mounted across the top portion of the microwave applicator aperture acts to block microwave radiation from illuminating the base of the breast and chest wall area. The patient treatment table utilizes a metallic shield to shield the body from stray microwave radiation. Combined E-field and temperature sensors within a single catheter are used to require only a single minimally invasive skin entry point for E-field focusing and measurement of the tumor temperature. Breast compression is maintained for a period of time following microwave-induced heating to accumulate additional equivalent thermal dose. Treatments incorporating the safety improvements include thermotherapy for early-stage breast carcinomas, locally advanced breast cancer, ductal carcinoma in-situ, and benign breast lesions.

摘要翻译： 使用外部聚焦的自适应相控阵微波热疗法（热疗）用于乳腺癌治疗的方法和装置包括微波吸收垫和金属屏蔽物，以防止不期望的或杂散的表面组织加热并且在乳房压缩期间使乳房缓冲乳房的机械压力。 微波吸收垫连接在微波波导热疗器施加器的顶部并且在乳房压缩桨的顶部。 安装在微波加工器孔的顶部的金属屏蔽条用于阻止微波辐射照射乳房和胸壁区域的基部。 患者治疗台使用金属屏蔽来屏蔽身体免受杂散微波辐射。 单个导管内的组合电场和温度传感器仅用于仅需要单个微创皮肤入口点进行电场聚焦和测量肿瘤温度。 乳房压缩在微波诱导加热后保持一段时间，以累积额外的等效热剂量。 结合安全改善的治疗包括早期乳腺癌的热疗，局部晚期乳腺癌，原位导管癌和良性乳腺病变。

公开(公告)号：US06807446B2

公开(公告)日：2004-10-19

申请号：US10233012

申请日：2002-09-03

申请人： Alan J. Fenn ,  John Mon ,  Dennis Smith

发明人： Alan J. Fenn ,  John Mon ,  Dennis Smith

IPC分类号： A61N502

CPC分类号： A61N1/403

摘要： A monopole phased array thermotherapy applicator radiating radiofrequency energy for inducing a temperature rise in a target within a body includes a plurality of monopole elements each for transmitting electric-field radiation; a metallic waveguide with an RF reflecting ground plane surface with a plurality of circular holes for mounting the monopole elements where the metallic waveguide forms an aperture for receiving a body to be treated; a waveform generator providing a source of electric field coupled to each monopole radiating element through a respective phase and power weighting network; at least one electric field probe positioned on a skin surface of the body for detecting electric field radiation from the plurality of monopole elements; and a controller circuit coupled to the electric field probe received feedback signals to adjust the phase and power delivered to the plurality of monopole elements so that one or more adaptive nulls are formed on the surface of the body and a focus is formed at the target tissue to be treated with thermotherapy.

公开(公告)号：US20120303103A1

公开(公告)日：2012-11-29

申请号：US13523096

申请日：2012-06-14

申请人： John Mon ,  Dennis Smith

发明人： John Mon ,  Dennis Smith

IPC分类号： A61N5/02

CPC分类号： A61B18/1815 ,  A61B18/18

摘要： A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The warmed circulated fluid inflates a balloon to a pressure to compress the tissue to form a natural stent that remains after the catheter and compression balloon are removed.

摘要翻译： 使用热疗治疗身体导管附近的组织的方法和装置，同时防止由于水肿导致的身体导管的障碍，采用温热流体的循环来维持身体导管壁的温度并压缩待治疗的组织以增加 辐照热的有效性。 将包含能量发射源的导管插入身体导管中并定位在待治疗组织的区域中，使得能量发射源将能量辐射到待治疗组织。 加热至超过30℃的流体循环进入导管并通过导管，使其靠近导管的身体导管的温暖壁。 加热的循环流体使气囊膨胀至压力以压缩组​​织以形成在导管和压缩气囊被移除之后保留的天然支架。

公开(公告)号：US07811313B2

公开(公告)日：2010-10-12

申请号：US10879288

申请日：2004-06-30

申请人： John Mon ,  Dennis Smith

发明人： John Mon ,  Dennis Smith

IPC分类号： A61F7/00

CPC分类号： A61B18/1815 ,  A61B18/18

摘要： A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C. being circulated adjacent the bodily conduit to maintain the warmth in its walls and the compression of the tissue to be treated enables a natural stent to be formed that remains after the catheter and compression balloon is removed.

摘要翻译： 使用热疗法处理邻近身体导管的组织的方法和装置，同时防止由于水肿导致的身体导管的障碍，采用温热流体的循环来维持身体导管壁的温度并压缩待治疗的组织以增加 辐照热的有效性。 将包含能量发射源的导管插入身体导管中并定位在待治疗组织的区域中，使得能量发射源将能量辐射到待治疗组织。 加热至超过30℃的流体循环进入导管并通过导管，使其靠近导管的身体导管的温暖壁。 循环的流体使气囊膨胀至压力以压缩待治疗的组织。 超过30℃的温热流体的组合在身体导管附近循环以保持其壁中的温暖并且待处理的组织的压缩使得能够形成在导管和压缩气囊被移除之后保留的天然支架。

公开(公告)号：US08221413B2

公开(公告)日：2012-07-17

申请号：US12849458

申请日：2010-08-03

申请人： John Mon ,  Dennis Smith

发明人： John Mon ,  Dennis Smith

IPC分类号： A61B18/18

CPC分类号： A61B18/1815 ,  A61B18/18

摘要： A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C. being circulated adjacent the bodily conduit to maintain the warmth in its walls and the compression of the tissue to be treated enables a natural stent to be formed that remains after the catheter and compression balloon is removed.

摘要翻译： 使用热疗治疗身体导管附近的组织的方法和装置，同时防止由于水肿导致的身体导管的障碍，采用温热流体的循环来维持身体导管壁的温度并压缩待治疗的组织以增加 辐照热的有效性。 将包含能量发射源的导管插入身体导管中并定位在待治疗组织的区域中，使得能量发射源将能量辐射到待治疗组织。 加热至超过30℃的流体循环进入导管并通过导管，使其靠近导管的身体导管的温暖壁。 循环的流体使气囊膨胀至压力以压缩待治疗的组织。 超过30℃的温热流体的组合在身体导管附近循环以保持其壁中的温暖并且待处理的组织的压缩使得能够形成在导管和压缩气囊被移除之后保留的天然支架。

公开(公告)号：US06958075B2

公开(公告)日：2005-10-25

申请号：US09954194

申请日：2001-09-18

申请人： John Mon ,  Dennis Smith

发明人： John Mon ,  Dennis Smith

IPC分类号： A61F7/08 ,  A61B18/18 ,  A61F7/12 ,  A61M25/00 ,  A61N5/04 ,  A61F7/00

CPC分类号： A61B18/1815 ,  A61B18/18

摘要： A method and apparatus of treating tissue adjacent to a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema employs the circulation of warmed fluid to maintain the temperature of the bodily conduit walls and compresses the tissue to be treated to increase the effectiveness of the irradiated heat. An energy-emitting source containing catheter is inserted in a bodily conduit and is positioned in a region of the tissue to be treated so that the energy-emitting source radiates energy to the tissue to be treated. Fluid warmed to over 30° C. is circulated into and through the catheter to warm walls of the bodily conduit adjacent the catheter. The circulated fluid inflates a balloon to a pressure to compress the tissue to be treated. The combination of warmed fluid over 30° C. being circulated adjacent the bodily conduit to maintain the warmth in its walls and the compression of the tissue to be treated enables a natural stent to be formed that remains after the catheter and compression balloon is removed.

摘要翻译： 使用热疗法处理邻近身体导管的组织的方法和装置，同时防止由于水肿导致的身体导管的障碍，采用温热流体的循环来维持身体导管壁的温度并压缩待治疗的组织以增加 辐照热的有效性。 将包含能量发射源的导管插入身体导管中并定位在待治疗组织的区域中，使得能量发射源将能量辐射到待治疗组织。 加热至超过30℃的流体循环进入导管并通过导管，使其靠近导管的身体导管的温暖壁。 循环的流体使气囊膨胀至压力以压缩待治疗的组织。 超过30℃的温热流体的组合在身体导管附近循环以保持其壁中的温暖并且待处理的组织的压缩使得能够形成在导管和压缩气囊被移除之后保留的天然支架。

公开(公告)号：US08975438B2

公开(公告)日：2015-03-10

申请号：US13541795

申请日：2012-07-05

申请人： Beat Birrer ,  Leo Clarke ,  Walter Deichtmann ,  John Hayes ,  Julius Jeisy ,  Christian Lautz ,  Rainer E. Martin ,  Michael Meade ,  Joaquim Pintao ,  Michelangelo Scalone ,  Juergen Schaefer ,  Dennis Smith ,  Andreas Staempfli ,  Joachim Veits ,  Christian Walch ,  Andrew Walsh ,  Andreas Zogg

发明人： Beat Birrer ,  Leo Clarke ,  Walter Deichtmann ,  John Hayes ,  Julius Jeisy ,  Christian Lautz ,  Rainer E. Martin ,  Michael Meade ,  Joaquim Pintao ,  Michelangelo Scalone ,  Juergen Schaefer ,  Dennis Smith ,  Andreas Staempfli ,  Joachim Veits ,  Christian Walch ,  Andrew Walsh ,  Andreas Zogg

IPC分类号： C07C259/04 ,  C07C319/20 ,  C07C51/06 ,  C07C51/08 ,  C07C319/06 ,  C07C327/30 ,  C07C51/02

CPC分类号： C07C319/20 ,  C07C51/02 ,  C07C51/06 ,  C07C51/08 ,  C07C319/06 ,  C07C327/30 ,  C07C2601/14 ,  C07C323/40 ,  C07C61/08

摘要： A process for the preparation of a compound of formula (I): which is useful as an intermediate in the preparation of pharmaceutically active compounds.

摘要翻译： 制备式（I）化合物的方法：其可用作药物活性化合物的制备中的中间体。

公开(公告)号：US20120143010A1

公开(公告)日：2012-06-07

申请号：US13308127

申请日：2011-11-30

申请人： Anthony P. Deasey ,  Steven J. Kubisen ,  David J. Hicks ,  Dennis Smith

发明人： Anthony P. Deasey ,  Steven J. Kubisen ,  David J. Hicks ,  Dennis Smith

IPC分类号： A61B1/32

CPC分类号： A61F13/36 ,  A61B17/02 ,  A61B17/0218 ,  A61B2017/0212

摘要： A device for human organ packing in a laproscopic surgical procedure, including an expandable barrier configured to be laproscopically implanted into a human abdominal cavity such that a side of the expandable barrier interfaces with organs in the abdominal cavity, thereby forming a barrier between the organs and a region of the abdominal cavity on an opposing side of the barrier relative to the organs, wherein at least a portion of the barrier is configured to be controllably transformed from a first state to a second state, wherein when in the second state the barrier is in a more rigid state relative to the first state.

摘要翻译： 一种用于在腹腔镜外科手术中进行人体器官包装的装置，包括可扩张的屏障，其被构造成腹腔镜植入人腹腔，使得可扩张的屏障的一侧与腹腔中的器官相接触，从而在器官和 在所述屏障的相对于所述器官的相对侧上的腹腔区域，其中所述屏障的至少一部分被配置为可控地从第一状态变换到第二状态，其中当处于所述第二状态时， 处于相对于第一状态的更刚性状态。

公开(公告)号：US20070060711A1

公开(公告)日：2007-03-15

申请号：US11227335

申请日：2005-09-15

申请人： K. Perera ,  Dennis Smith ,  J. Moreland ,  Kevin Wallace

发明人： K. Perera ,  Dennis Smith ,  J. Moreland ,  Kevin Wallace

IPC分类号： C08F136/00

CPC分类号： C08G77/382 ,  B60C1/00 ,  C08C19/25 ,  C08F8/42 ,  C08J11/04 ,  C08J2321/00 ,  Y02P20/143 ,  Y02W30/70 ,  C08F210/12

摘要： The present invention relates to a modified crumb rubber particle having carbon to silicon bonds created by the reaction of the unsaturation in the crumb rubber particle and silicon hydride, with or without the use of a catalyst. Bound silicon content ranges from about 0.1% to 10% by weight. The silicon-modified crumb rubber can be used as is or a reinforcing filler in formulations. Typically the silicon-modified crumb rubber is used in up to 25% by weight of the total rubber present in virgin rubber compositions.

摘要翻译： 本发明涉及通过或不使用催化剂，通过在橡胶颗粒和硅氢化物中的不饱和键的反应产生碳 - 硅键的改性碎屑橡胶颗粒。 结合硅含量为约0.1％至10％重量。 硅改性碎屑橡胶可以原样使用或在制剂中使用增强填料。 通常，硅改性的碎屑橡胶以高达原始橡胶组合物中存在的总橡胶的25重量％使用。

公开(公告)号：US20050268735A1

公开(公告)日：2005-12-08

申请号：US10161031

申请日：2002-06-03

申请人： Dennis Smith ,  Toren Davis

发明人： Dennis Smith ,  Toren Davis

IPC分类号： F16F9/00 ,  F16F15/10 ,  F16F15/16 ,  F16F15/30

CPC分类号： F16F9/006 ,  B64G1/286 ,  F16F15/16 ,  F16F15/30 ,  Y10T74/12 ,  Y10T74/2122 ,  Y10T74/2126

摘要： According to the preferred exemplary embodiments of the present invention, there is provided an apparatus and method for selecting an appropriate viscous fluid for use in control moment gyroscopes, reaction wheels, momentum wheels and the like. By modeling components such as the housing, the rotor, and the viscous fluid using a three-parameter isolator system, the most effective damping action can be achieved for a given application.

摘要翻译： 根据本发明的优选示例性实施例，提供了一种用于选择用于控制力矩陀螺仪，反作用轮，动量轮等中的适当粘性流体的装置和方法。 通过使用三参数隔离器系统对诸如壳体，转子和粘性流体的部件进行建模，对于给定的应用可以实现最有效的阻尼作用。