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6 条记录 (耗时 0.017 秒)

    Collapsible containment wall for imaging
    1.
    发明授权
    Collapsible containment wall for imaging 有权
    可折叠遏制墙成像

    公开(公告)号：US08086295B2

    公开(公告)日：2011-12-27

    申请号：US11846543

    申请日：2007-08-29

    申请人： Alan Love ,  King Li

    发明人： Alan Love ,  King Li

    IPC分类号： A61B5/05 ,  G01V3/00

    CPC分类号： A61B6/00 ,  A61B5/0046 ,  A61B5/055 ,  A61B6/10 ,  A61B2090/0436 ,  G01N24/084 ,  G01R33/288 ,  G01R33/30

    摘要： A retractable containment wall separates an imaging suite into two sections: a “hot” or contaminated section and a “cold” or non-contaminated section. The wall includes a center portion and retractable peripheral portions. Each retractable portion is made up of several panels. Between panels, between a panel and a room wall, and between a panel and the center portion are tongue and groove seals that mate to form seals at seams in the wall when the wall is deployed. Guide pins propagate along a guide track to facilitate transition of the portions between deployed and retracted orientations. The center portion includes a tube that extends into the imaging region of a diagnostic imaging device located in the non-contaminated portion of the imaging suite. The subject is inserted into the tube in preparation for an imaging procedure.

    摘要翻译： 可收缩的容纳墙将成像套件分成两部分：“热”或污染部分和“冷”或非污染部分。 该壁包括中心部分和可缩回的周边部分。 每个伸缩部分由几个面板组成。 在面板之间，面板和房间壁之间以及面板和中心部分之间的是面板和凹槽密封件，当壁部署时，它们与墙壁中的接缝处形成密封。 引导销沿导轨传播，以便部署在展开方向和缩回方向之间的过渡。 中心部分包​​括延伸到位于成像套件的未被污染部分的诊断成像装置的成像区域中的管。 将受试者插入管中以准备成像过程。

    Integrin alpha-v beta-3 antagonists for use in imaging and therapy
    2.
    发明申请
    Integrin alpha-v beta-3 antagonists for use in imaging and therapy 有权
    用于成像和治疗的整合素α-vβ-3拮抗剂

    公开(公告)号：US20060030575A1

    公开(公告)日：2006-02-09

    申请号：US10911988

    申请日：2004-08-04

    申请人： S. Danthi ,  King Li ,  Christopher Burnett

    发明人： S. Danthi ,  King Li ,  Christopher Burnett

    IPC分类号： A61K31/505 ,  C07D239/12

    CPC分类号： C07D239/14

    摘要： Integrin receptor antagonists whose molecular structure includes a tetrahydropyridimidinylaminoethyloxybenzoyl group on a sulfonylamino-β-alanine nucleus exhibit increased binding affinity for the αvβ3 receptor when further substituted on the sulfonyl moiety with an N-amino alkycarbamyl group or a butyloxycarbonylamino alkylcarbamoyl group or similar groups.

    摘要翻译： 在磺酰基氨基-β-丙氨酸核上分子结构包括四氢吡啶基氨基乙氧基苯甲酰基的整联蛋白受体拮抗剂在磺酰基部分用N-氨基烷基氨基甲酰基或丁基氧基羰基氨基烷基氨基甲酰基或类似基团进一步取代时，表现出对α2β3受体的结合亲和力。

    Small Molecules for Imaging Protein-Protein Interactions
    3.
    发明申请
    Small Molecules for Imaging Protein-Protein Interactions 有权
    用于成像蛋白质 - 蛋白质相互作用的小分子

    公开(公告)号：US20080085238A1

    公开(公告)日：2008-04-10

    申请号：US11762579

    申请日：2007-06-13

    申请人： King Li ,  S. Danthi

    发明人： King Li ,  S. Danthi

    IPC分类号： A61K49/00 ,  A61K51/00 ,  A61P43/00 ,  C07C211/00

    CPC分类号： C07C237/40 ,  A61K49/0043 ,  A61K49/0052 ,  G01N2333/4709

    摘要： A tissue is imaged to detect the presence of amyloid deposits or other target proteins prior to their aggregation into plaques, with the assistance of the administration of a labeled bifunctional compound of which one functionality binds to the target protein and the second functionality binds to a chaperone protein that is present in the tissue of interest. The two functionalities have different binding affinities, the target-binding functionality having the greater binding affinity, with the result that the bifunctional compound preferentially remains in the tissue when bound to the chaperone and then the target protein while bifunctional compound that is not bound to the target protein will leave the tissue. The inclusion of the chaperone allows the imaging process to detect the non-aggregated proteins by way of the label and the difference in kinetics of the binding to the chaperone and the target protein permits one to distinguish between binding of the bifunctional molecule to the chaperone only and binding to the chaperone and then to the target protein. Certain intermediates toward the synthesis of these bifunctional compounds are novel by themselves, and labeled bifunctional molecules in general that utilize a lysine linker are also disclosed as a novel class of compounds.

    摘要翻译： 成像组织以在其聚集成斑块之前检测淀粉样蛋白沉积物或其它靶蛋白的存在，借助于施用其中一个功能性与目标蛋白质结合的标记的双功能化合物，并且第二官能团结合于分子伴侣 存在于感兴趣组织中的蛋白质。 这两个功能具有不同的结合亲和力，靶结合功能具有更大的结合亲和力，结果是当与分子伴侣结合时，双功能化合物优先保留在组织中，然后与靶蛋白结合，而不结合到 靶蛋白会离开组织。 分子伴侣的包含允许成像过程通过标记检测非聚集的蛋白质，并且与伴侣和靶蛋白结合的动力学差异允许区分双功能分子与分子伴侣的结合 并结合分子伴侣，然后结合到靶蛋白。 合成这些双功能化合物的某些中间体本身是新的，并且一般使用赖氨酸连接物的标记的双功能分子也被公开为新类化合物。

    Intracellular trapping of radionuclides by enzyme-mediated reduction
    4.
    发明申请
    Intracellular trapping of radionuclides by enzyme-mediated reduction 审中-公开
    通过酶介导的还原对细胞内捕获放射性核素

    公开(公告)号：US20070009437A1

    公开(公告)日：2007-01-11

    申请号：US11390965

    申请日：2006-03-28

    申请人： Fangyu Peng ,  King Li ,  Sunil Pandit

    发明人： Fangyu Peng ,  King Li ,  Sunil Pandit

    IPC分类号： A61K51/00 ,  C12Q1/68

    CPC分类号： C12N9/0067 ,  A61K48/005 ,  A61K51/025

    摘要： Enzyme-mediated intracellular trapping of a radionuclide in a target cell is achieved by transfecting the target cell with a transgenic vector encoding a microbial hydrogenase expressible in the target cell and exposing the transfected target cell with a radionuclide. The transgenically expressed microbial hydrogenase catalyzes the reduction of the radionuclide. The reduced radionuclide becomes trapped intracellularly where its emissions can be detected in radioscintigraphy applications. In addition, emissions from an intracellularly trapped radionuclide can be cytotoxic to the cell and therefore useful in radiotherapy applications. As a reporter, a microbial hydrogenase encoding nucleic acid can be included in a vector along with a transgene, both under the control of the same promoter. The detection of emissions from intracellularly reduced and trapped radionuclide can be used to monitor transgene expression.

    摘要翻译： 通过用编码在靶细胞中可表达的微生物氢化酶的转基因载体转染靶细胞并用放射性核素暴露转染的靶细胞，实现靶细胞中放射性核素的酶介导的细胞内捕获。 转基因表达的微生物氢化酶催化还原放射性核素。 减少的放射性核素在细胞内被捕获，其中可以在放射线印迹应用中检测其排放。 此外，来自细胞内捕获的放射性核素的排放物可能对细胞具有细胞毒性，因此可用于放射治疗应用。 作为报告者，编码微生物氢化酶的核酸可以与转基因一起包含在载体中，两者都在同一启动子的控制下。 检测来自细胞内减少和捕获的放射性核素的排放物可用于监测转基因表达。