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1.发明授权Method of using isotropic, porous-wall polymeric membrane, hollow-fibers for culture of microbes 失效使用各向同性的多孔壁聚合物膜，用于培养微生物的中空纤维的方法
公开(公告)号：US4442206A
公开(公告)日：1984-04-10
申请号：US489609
申请日：1983-05-04
申请人： Alan S. Michaels , Channing R. Robertson , Stanley N. Cohen , Douglas S. Inloes , William J. Smith
发明人： Alan S. Michaels , Channing R. Robertson , Stanley N. Cohen , Douglas S. Inloes , William J. Smith
CPC分类号： B01D63/02 , B01D69/141 , C12M29/10 , C12M29/16 , Y10S435/813
摘要： Hollow fiber reactors for growing microbial cells. Isotropic hollow fibers are supported in a housing inoculated with cells. Nutrient medium passing through the lumen undergoes a pressure drop resulting in radial convective flow: the nutrient medium flows outwardly from the lumen into the surrounding area adjacent the entry port and fluid surrounding the hollow fiber flows into the lumen adjacent the exit port. With the efficient distribution of nutrients and removal of product, high cell densities are achieved providing for high product yields per unit reactor volume.
摘要翻译： 用于生长微生物细胞的中空纤维反应器。 各种各样的中空纤维支撑在接种细胞的外壳中。 通过内腔的营养介质经历压力降，导致径向对流流动：营养介质从内腔向外流入邻近入口的周围区域，围绕中空纤维的流体流入与出口相邻的管腔。 通过营养物质的有效分配和产品的去除，实现高的细胞密度，提供每单位反应器体积的高产物产量。
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公开(公告)号：US4440853A
公开(公告)日：1984-04-03
申请号：US504599
申请日：1983-06-20
CPC分类号： B01D63/02 , B01D69/141 , C12M25/10 , C12M29/16 , B01D2325/022 , Y10S435/813
摘要： Methods for microbiological processing of organic materials for production of valuable products. Asymmetric hollow fibers are employed in a flow reactor, where the hollow fibers have a semipermeable membrane surrounding a lumen, where the semipermeable membrane is supported by a sponge structure. The pores of the sponge structure serve as a housing for microorganisms or cells with high density packing of the microorganisms or cells in the pores. Nutrient medium continuously flowing through the lumen provides nutrients to the microorganisms or cells as well as any substrates to be processed by the microorganisms or cells. The nutrients and substrates diffuse through the semipermeable membrane into the pores, where they are processed, and the metabolic products diffuse into the lumen. The lumen effluent is then processed for the desired products. Optionally, oxygen is provided external to the hollow fiber to enhance the amount of oxygen available to the microorganisms and cells.
摘要翻译： 微生物加工有机材料生产有价值产品的方法。 不对称中空纤维用于流动反应器，其中中空纤维具有围绕管腔的半透膜，其中半透膜由海绵结构支撑。 海绵结构的孔用作微生物或细胞的壳体，其具有微孔或细胞在孔中的高密度填充。 持续流经内腔的营养培养基向微生物或细胞以及由微生物或细胞处理的任何基质提供营养。 营养物质和底物通过半透膜扩散进入毛孔，在那里进行处理，代谢产物扩散到管腔中。 然后将流明流出物加工成所需产品。 任选地，在中空纤维外部提供氧以增强可用于微生物和细胞的氧气的量。
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公开(公告)号：US4946795A
公开(公告)日：1990-08-07
申请号：US395808
申请日：1989-08-18
CPC分类号： B01F13/0059 , B01F13/0818 , B01F15/04 , G01N1/38 , G01N33/04 , Y10T436/25625 , Y10T436/2575
摘要： An apparatus for diluting a sample with a diluent, comprising a fixed volume measuring chamber, a fixed volume receiving chamber and fluid receiving relationship to the measuring chamber, a gas vent in the receiving chamber, a stop flow junction between the measuring chamber and the receiving chamber, a sample application site in fluid donating relationship to the measuring chamber, wherein the vertical height difference between the sample application site and the stop flow junction is insufficient to provide a hydrostatic pressure capable of overcoming backpressure at the stop flow junction when sample is applied to the sample application site, and the diluent application site and fluid donating relationship to the measuring chamber. Sample and diluent are added sequentially to the apparatus of the invention without requiring any intervening operations. Various means are provided for restarting flow, which causes diluent to wash the sample into the receiving chamber, where the two can be mixed.
摘要翻译： 一种用稀释剂稀释样品的装置，包括固定容积测量室，固定容积接收室和与测量室的流体接收关系，接收室中的气体通道，测量室和接收器之间的停止流动接合 室，与测量室的流体供应关系的样品施加部位，其中样品施加部位和止动流动接合点之间的垂直高度差不足以提供当施加样品时能够克服止动流动接合处的背压的静水压力 到样品应用场所，以及稀释剂施用部位和与测量室的流体供给关系。 样品和稀释剂依次添加到本发明的装置中，而不需要任何中间操作。 提供了重新启动流动的各种装置，这使得稀释剂将样品洗涤到接收室中，其中两个可以混合。
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公开(公告)号：US4868129A
公开(公告)日：1989-09-19
申请号：US90026
申请日：1987-08-27
CPC分类号： G01N1/38 , B01F13/0059 , B01F13/0818 , B01F15/04 , B01L3/5027 , G01N33/04 , Y10T436/25625 , Y10T436/2575
摘要： An apparatus for diluting a sample with a diluent, comprising a fixed volume measuring chamber, a fixed volume receiving chamber and fluid receiving relationship to the measuring chamber, a gas vent in the receiving chamber, a stop flow junction between the measuring chamber and the receiving chamber, a sample application site in fluid donating relationship to the measuring chamber, wherein the vertical height difference between the sample application site and the stop flow junction is insufficient to provide a hydrostatic pressure capable of overcoming backpressure at the stop flow junction when sample is applied to the sample application site, and the diluent application site and fluid donating relationship to the measuring chamber. Sample and diluent are added sequentially to the apparatus of the invention without requiring any intervening operations. Various means are provided for restarting flow, which causes diluent to wash the sample into the receiving chamber, where the two can be mixed.
摘要翻译： 一种用稀释剂稀释样品的装置，包括固定容积测量室，固定容积接收室和与测量室的流体接收关系，接收室中的气体通道，测量室和接收器之间的停止流动接合 室，与测量室的流体供应关系的样品施加部位，其中样品施加部位和止动流动接合点之间的垂直高度差不足以提供当施加样品时能够克服止动流动接合处的背压的静水压力 到样品应用场所，以及稀释剂施用部位和与测量室的流体供给关系。 样品和稀释剂依次添加到本发明的装置中，而不需要任何中间操作。 提供了重新启动流动的各种装置，这使得稀释剂将样品洗涤到接收室中，其中两个可以混合。
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公开(公告)号：US06062681A
公开(公告)日：2000-05-16
申请号：US114978
申请日：1998-07-14
申请人： Leslie A. Field , Stefano Schiaffino , Phillip W. Barth , Storrs T. Hoen , Naoto A. Kawamura , David K. Donald , Channing R. Robertson , Jonathan D. Servaites
发明人： Leslie A. Field , Stefano Schiaffino , Phillip W. Barth , Storrs T. Hoen , Naoto A. Kawamura , David K. Donald , Channing R. Robertson , Jonathan D. Servaites
CPC分类号： B41J2/17596 , B41J2/19 , Y10S366/03
摘要： A bubble valve that comprises a liquid delivery channel and a localized heating arrangement. The liquid delivery channel includes an upstream portion and a constriction downstream of the upstream portion. The constriction has a smaller cross-sectional area than the upstream portion. The localized heating arrangement is located in the liquid delivery channel and generates heat to nucleate and enlarge a bubble in the liquid. The constriction is shaped to form a seal with the bubble. The localized heating arrangement additionally generates heat to move the bubble relative to the constriction to control the flow of the liquid. A pressure regulator that comprises a liquid delivery channel connected to a liquid outlet, a sensor located adjacent the liquid outlet, a controller that operates in response to the sensor and a localized heating arrangement. The liquid delivery channel includes an upstream portion, and a constriction located between the upstream portion and the liquid outlet. The constriction has a smaller cross-sectional area than the upstream portion. The localized heating arrangement is located in the liquid delivery channel and generates heat in response to the controller to nucleate and enlarge a bubble in the liquid. The constriction is shaped to form a seal with the bubble. The localized heating arrangement additionally generates heat to move the bubble relative to the constriction to control the flow of the liquid to the liquid outlet.
摘要翻译： 气泡阀，其包括液体输送通道和局部加热装置。 液体输送通道包括上游部分的下游部分和收缩部分。 缩颈具有比上游部分更小的横截面面积。 局部加热装置位于液体输送通道中并产生热量以成核并扩大液体中的气泡。 缩颈被成形为与气泡形成密封。 局部加热装置另外产生热量以相对于收缩部移动气泡以控制液体的流动。 一种压力调节器，包括连接到液体出口的液体输送通道，位于液体出口附近的传感器，响应于传感器操作的控制器和局部加热装置。 液体输送通道包括上游部分和位于上游部分和液体出口之间的收缩部。 缩颈具有比上游部分更小的横截面面积。 局部加热装置位于液体输送通道中，响应于控制器产生热量以成核并扩大液体中的气泡。 缩颈被成形为与气泡形成密封。 局部加热装置另外产生热量以相对于收缩部移动气泡以控制液体流到液体出口的流动。
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6.发明授权Passive pressure regulator for setting the pressure of a liquid to a predetermined pressure differential below a reference pressure 失效被动压力调节器，用于将液体的压力设定在低于参考压力的预定压力差
公开(公告)号：US5969736A
公开(公告)日：1999-10-19
申请号：US116427
申请日：1998-07-14
申请人： Leslie A. Field , Phillip Barth , David J. Waller , George D. Zuras, Jr. , Paul P. Merchant , Storrs Hoen , Channing R. Robertson
发明人： Leslie A. Field , Phillip Barth , David J. Waller , George D. Zuras, Jr. , Paul P. Merchant , Storrs Hoen , Channing R. Robertson
CPC分类号： B41J2/17556 , B41J2/055 , B41J2202/05
摘要： A pressure regulator that sets the pressure of a liquid to a predetermined pressure differential below a reference pressure, such as atmospheric pressure. The pressure regulator comprises a liquid delivery channel and a capillary array. The liquid delivery channel includes a liquid input and a liquid output. The liquid flows through the liquid delivery channel from the liquid input to the liquid output. The capillary array is composed of ones of an elongate capillary. The capillary includes a first end in fluid communication with the liquid delivery channel and a second end in pressure communication with a source of the reference pressure. The liquid flows through the first end into the capillary to form a liquid surface in the capillary. The second end is remote from the first end. The capillary has cross-sectional dimensions in relation to the surface tension of the liquid and the angle of contact between the liquid and the capillary such that the pressure drop across the liquid surface in the capillary is equal to the predetermined pressure differential.
摘要翻译： 一种压力调节器，其将液体的压力设定为低于参考压力（例如大气压）的预定压差。 压力调节器包括液体输送通道和毛细管阵列。 液体输送通道包括液体输入和液体输出。 液体通过液体输送通道从液体输入流到液体输出。 毛细管阵列由细长毛细管组成。 毛细管包括与液体输送通道流体连通的第一端和与参考压力的源压力连通的第二端。 液体通过第一端流入毛细管，以在毛细管中形成液体表面。 第二端远离第一端。 毛细管具有与液体的表面张力和液体和毛细管之间的接触角相关的横截面尺寸，使得毛细管中的液体表面上的压降等于预定的压力差。
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