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1.发明授权Method of using isotropic, porous-wall polymeric membrane, hollow-fibers for culture of microbes 失效使用各向同性的多孔壁聚合物膜，用于培养微生物的中空纤维的方法
公开(公告)号：US4442206A
公开(公告)日：1984-04-10
申请号：US489609
申请日：1983-05-04
申请人： Alan S. Michaels , Channing R. Robertson , Stanley N. Cohen , Douglas S. Inloes , William J. Smith
发明人： Alan S. Michaels , Channing R. Robertson , Stanley N. Cohen , Douglas S. Inloes , William J. Smith
CPC分类号： B01D63/02 , B01D69/141 , C12M29/10 , C12M29/16 , Y10S435/813
摘要： Hollow fiber reactors for growing microbial cells. Isotropic hollow fibers are supported in a housing inoculated with cells. Nutrient medium passing through the lumen undergoes a pressure drop resulting in radial convective flow: the nutrient medium flows outwardly from the lumen into the surrounding area adjacent the entry port and fluid surrounding the hollow fiber flows into the lumen adjacent the exit port. With the efficient distribution of nutrients and removal of product, high cell densities are achieved providing for high product yields per unit reactor volume.
摘要翻译： 用于生长微生物细胞的中空纤维反应器。 各种各样的中空纤维支撑在接种细胞的外壳中。 通过内腔的营养介质经历压力降，导致径向对流流动：营养介质从内腔向外流入邻近入口的周围区域，围绕中空纤维的流体流入与出口相邻的管腔。 通过营养物质的有效分配和产品的去除，实现高的细胞密度，提供每单位反应器体积的高产物产量。
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公开(公告)号：US4440853A
公开(公告)日：1984-04-03
申请号：US504599
申请日：1983-06-20
CPC分类号： B01D63/02 , B01D69/141 , C12M25/10 , C12M29/16 , B01D2325/022 , Y10S435/813
摘要： Methods for microbiological processing of organic materials for production of valuable products. Asymmetric hollow fibers are employed in a flow reactor, where the hollow fibers have a semipermeable membrane surrounding a lumen, where the semipermeable membrane is supported by a sponge structure. The pores of the sponge structure serve as a housing for microorganisms or cells with high density packing of the microorganisms or cells in the pores. Nutrient medium continuously flowing through the lumen provides nutrients to the microorganisms or cells as well as any substrates to be processed by the microorganisms or cells. The nutrients and substrates diffuse through the semipermeable membrane into the pores, where they are processed, and the metabolic products diffuse into the lumen. The lumen effluent is then processed for the desired products. Optionally, oxygen is provided external to the hollow fiber to enhance the amount of oxygen available to the microorganisms and cells.
摘要翻译： 微生物加工有机材料生产有价值产品的方法。 不对称中空纤维用于流动反应器，其中中空纤维具有围绕管腔的半透膜，其中半透膜由海绵结构支撑。 海绵结构的孔用作微生物或细胞的壳体，其具有微孔或细胞在孔中的高密度填充。 持续流经内腔的营养培养基向微生物或细胞以及由微生物或细胞处理的任何基质提供营养。 营养物质和底物通过半透膜扩散进入毛孔，在那里进行处理，代谢产物扩散到管腔中。 然后将流明流出物加工成所需产品。 任选地，在中空纤维外部提供氧以增强可用于微生物和细胞的氧气的量。
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公开(公告)号：US5413791A
公开(公告)日：1995-05-09
申请号：US198128
申请日：1994-02-17
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , A61F13/00 , A61K9/14 , A61K9/50
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The collagen-polymer conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.
摘要翻译： 药学上可接受的非免疫原性组合物通过经由特定类型的化学键共价结合肽肽胶原与药学纯合成的亲水性聚合物形成，以提供胶原/聚合物共轭物。 糖尿病胶原可以是I型，II型或III型，并且可以是纤维状或非纤维状的。 合成亲水性聚合物可以是重均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。 组合物可以包括其它组分，例如液体，药学上可接受的，载体以形成可注射制剂，和/或生物活性蛋白质例如生长因子。 当形成时，本发明的胶原 - 聚合物共轭物通常含有大量的水。 可以将共轭物脱水形成相对固体的物体。 脱水的固体可以被研磨成可以悬浮在诸如油之类的非水性流体中的颗粒，并注入活体以提供软组织增加。 一旦就位，颗粒再水合并扩大五倍以上。
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4.发明授权Bioreactor process for continuous removal of organic toxicants and other oleophilc solutes from an aqueous process stream 失效用于从含水工艺流中连续除去有机毒物和其他油性溶质的生物反应器方法
公开(公告)号：US4988443A
公开(公告)日：1991-01-29
申请号：US547862
申请日：1990-07-03
CPC分类号： C02F3/1231 , B01D17/085 , C02F3/34 , Y02W10/15 , Y10S210/908
摘要： A hollow fiber membrane bioreactor process for continuous selective removal of organic toxicants or other oleophilic solutes present in an aqueous process stream wherein low concentration levels of said toxicant are removed from the aqueous process stream by being extracted and concentrated by the permeably selective hollow fiber membrane and then provided to a microorganism for metabolization into a water soluble metabolite. The water soluble metabolite is prevented from reentering the aqueous process stream and removed from the bioreactor in the aqueous nutrient effluent stream.
摘要翻译： 一种用于连续选择性去除存在于水性工艺流中的有机毒物或其它亲油溶质的中空纤维膜生物反应器方法，其中通过被渗透性选择性中空纤维膜提取和浓缩从所述水性工艺流中除去所述毒物的低浓度水平， 然后提供给微生物代谢成水溶性代谢物。 防止水溶性代谢物重新进入含水工艺流并从含水养分流出物流中的生物反应器中除去。
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5.发明授权Dispenser powered by cross-linked hydrophilic polymer grafted to hydrophilic polymer 失效分配器由交联的亲水聚合物接枝到亲水聚合物上
公开(公告)号：US4367741A
公开(公告)日：1983-01-11
申请号：US218729
申请日：1980-12-22
申请人： Alan S. Michaels
发明人： Alan S. Michaels
CPC分类号： A61K9/0004 , A61L9/042 , A61M31/002
摘要： A dispenser is disclosed comprising a housing formed of a laminate of a cross-linked hydrophilic polymer layer grafted to a noncross-linked hydrophilic layer. The housing surrounds a container made of an elastomeric material and the container has an outlet through the housing to the exterior of the dispenser.
摘要翻译： 公开了一种分配器，其包括由接枝到非交联亲水层的交联的亲水性聚合物层的叠层形成的壳体。 壳体围绕由弹性体材料制成的容器，并且容器具有通过壳体到分配器外部的出口。
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公开(公告)号：US4340054A
公开(公告)日：1982-07-20
申请号：US220789
申请日：1980-12-29
申请人： Alan S. Michaels
发明人： Alan S. Michaels
CPC分类号： A61M5/1483 , A61K9/0004
摘要： An osmotically driven fluid dispenser is disclosed comprising a flexible container having a port for filling and emptying same, a layer of an osmotically effective solute on the container, and a shape retaining microporous housing having a fluid rate controlling material in its micropores. The dispenser can be used for delivering fluids and solid agents, and as a displacement pump.
摘要翻译： 公开了一种渗透驱动的流体分配器，其包括具有用于填充和排空的口的柔性容器，在容器上具有渗透性有效溶质的层，以及在其微孔中具有流体速率控制材料的形状保持微孔壳体。 分配器可用于输送流体和固体剂，以及作为排量泵。
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公开(公告)号：US4182330A
公开(公告)日：1980-01-08
申请号：US818292
申请日：1977-07-25
申请人： Alan S. Michaels
发明人： Alan S. Michaels
CPC分类号： A61K9/1075 , A61K9/0004
摘要： Means for administering an amphipathic medicament by micelle solubilization is disclosed. The micelle consists of a nonionic surfactant medicament adduct. The adduct is coated onto an osmotically effective solute and housed in an osmotic therapeutic system for administering the medicament in a therapeutically effective amount over a prolonged period of time.
摘要翻译： 公开了通过胶束溶解给药两性药物的方法。 胶束由非离子表面活性剂药物加合物组成。 将加合物包被在渗透性有效的溶质上并置于渗透治疗系统中，用于在长时间内以治疗有效量施用药物。
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公开(公告)号：US4036227A
公开(公告)日：1977-07-19
申请号：US536006
申请日：1974-12-23
CPC分类号： A61K9/0004 , A61F6/14 , A61F6/144 , A61F9/0017
摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid, or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
摘要翻译： 公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。 该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。 所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。 在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。 该试剂可溶于流体并且表现出跨越半透性壁抵抗流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，该溶质表现出穿过半透壁的渗透压梯度，抵抗 流体。 在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生 将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度 设备。
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公开(公告)号：US3993069A
公开(公告)日：1976-11-23
申请号：US605690
申请日：1975-08-18
CPC分类号： A61J1/05 , A61M5/152 , B65D83/0061 , Y10S128/12
摘要： An improvement in liquid dispensers, especially those used to infuse liquid drugs into patients from an expansible elastomeric bladder of specific geometry and elastomeric properties, is disclosed. The improvement is in making the bladder from an elastomeric composition whose stress relaxation does not exceed 10%, and whose low frequency hysteresis does not exceed 10%.
摘要翻译： 公开了液体分配器的改进，特别是那些用于将液体药物从具有特定几何形状和弹性体特性的可膨胀弹性体囊注入患者的液体分配器。 改进之处在于使弹性体组合物的应力松弛不超过10％，其低频滞后不超过10％。
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公开(公告)号：US06379556B1
公开(公告)日：2002-04-30
申请号：US09394325
申请日：1999-09-13
IPC分类号： C02F142
摘要： The recovery of iodide from chemical process wastewater is accomplished by loading the wastewater containing iodide onto a strongly basic anion-exchange resin in free-base form; eluting the sorbed iodide from the resin with aqueous strong acid (e.g., hydrochloric acid); loading the iodide-rich cuts onto a weakly basic anion-exchange resin in free-base form; and eluting the sorbed iodide with aqueous base (e.g., sodium hydroxide). The recovered iodide typically has sufficient purity to permit its re-use in the chemical process.
摘要翻译： 从化学处理废水中回收碘化物是通过将含有碘化物的废水以游离碱形式加载到强碱性阴离子交换树脂上来实现的; 用强酸水溶液（如盐酸）从树脂中洗脱吸附的碘化物; 将富含碘化物的切片以游离碱形式加载到弱碱性阴离子交换树脂上; 并用碱水溶液（例如氢氧化钠）洗脱吸附的碘化物。 回收的碘化物通常具有足够的纯度以允许其在化学过程中重复使用。
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