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    Devices and methods for the production of particles
    4.
    发明授权
    Devices and methods for the production of particles 失效
    用于生产颗粒的装置和方法

    公开(公告)号：US07332111B2

    公开(公告)日：2008-02-19

    申请号：US10483194

    申请日：2002-07-10

    申请人： Willy Grothe ,  Daniel Jarmer ,  Corinne Lengsfeld ,  Theodore Randolph

    发明人： Willy Grothe ,  Daniel Jarmer ,  Corinne Lengsfeld ,  Theodore Randolph

    IPC分类号： B29B9/00

    CPC分类号： B01J2/04 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0473 ,  B01F5/0057 ,  B01F2003/0064

    摘要： The present invention provides methods and devices for producing particles with an average diameter less than about 15 μm using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-BD) process. In the methods and nozzles of the invention, at least one jet of supercritical or near-supercritical fluid and at least one jet of solution interact to mix the supercritical or near-supercritical fluid and the solution within a chamber. The solution contains at least one solvent and at least one solute. At least one of the jets is a swirling jet. To form particles, the solvent and supercritical or near-supercritical fluid are then injected into a PCA or a CAN-BD process chamber. The degree of mixing depends in part on the power input into the mixing chamber. Power inputs of about 6.5×109 W/m3 enhance the degree of mixing and allow production of nanoscale particles with the PCA process. The nanoscale particles have a size distribution so that polydispersity is less than about 1.75.

    摘要翻译： 本发明提供了使用压缩流体 - 反溶剂（PCA）沉淀法和用气泡干燥器（CAN-BD）方法进行二氧化碳辅助雾化来生产平均直径小于约15μm的颗粒的方法和装置。 在本发明的方法和喷嘴中，至少一个超临界或近超临界流体射流和至少一个溶液射流相互作用以将超临界或近超临界流体和溶液在腔室内混合。 该溶液含有至少一种溶剂和至少一种溶质。 至少有一架喷气式飞机是旋流式飞机。 为了形成颗粒，然后将溶剂和超临界或近临界流体注入PCA或CAN-BD处理室中。 混合程度部分取决于输入混合室的功率。 大约6.5×10 9 W / m 3的功率输入提高了混合的程度并允许用PCA工艺生产纳米尺寸的颗粒。 纳米级颗粒具有尺寸分布，使得多分散性小于约1.75。

    Devices and methods for the production of particles
    5.
    发明申请
    Devices and methods for the production of particles 失效
    用于生产颗粒的装置和方法

    公开(公告)号：US20050051917A1

    公开(公告)日：2005-03-10

    申请号：US10483194

    申请日：2002-07-10

    申请人： Willy Grothe ,  Daniel Jarmer ,  Corinne Lengsfeld ,  Theodore Randolph

    发明人： Willy Grothe ,  Daniel Jarmer ,  Corinne Lengsfeld ,  Theodore Randolph

    IPC分类号： B01D11/04 ,  B01F5/00 ,  B01J2/04 ,  B29B9/00

    CPC分类号： B01J2/04 ,  B01D11/0403 ,  B01D11/0407 ,  B01D11/0473 ,  B01F5/0057 ,  B01F2003/0064

    摘要： The present invention provides methods and devices for producing particles with an average diameter less than about 15 μm using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-BD) process. In the methods and nozzles of the invention, at least one jet of supercritical or near-supercritical fluid and at least one jet of solution interact to mix the supercritical or near-supercritical fluid and the solution within a chamber. The solution contains at least one solvent and at least one solute. At least one of the jets is a swirling jet. To form particles, the solvent and supercritical or near-supercritical fluid are then injected into a PCA or a CAN-BD process chamber. The degree of mixing depends in part on the power input into the mixing chamber. Power inputs of about 6.5×109 W/m3 enhance the degree of mixing and allow production of nanoscale particles with the PCA process. The nanoscale particles have a size distribution so that polydispersity is less than about 1.75.

    摘要翻译： 本发明提供了使用压缩流体 - 反溶剂（PCA）沉淀法和用气泡干燥器（CAN-BD）方法进行二氧化碳辅助雾化来生产平均直径小于约15μm的颗粒的方法和装置。 在本发明的方法和喷嘴中，至少一个超临界或近超临界流体射流和至少一个溶液射流相互作用以将超临界或近超临界流体和溶液在腔室内混合。 该溶液含有至少一种溶剂和至少一种溶质。 至少有一架喷气式飞机是旋流式飞机。 为了形成颗粒，然后将溶剂和超临界或近临界流体注入PCA或CAN-BD处理室中。 混合程度部分取决于输入混合室的功率。 大约6.5×10 9 W / m 3的功率输入提高了混合的程度，并允许用PCA工艺生产纳米级颗粒。 纳米级颗粒具有尺寸分布，使得多分散性小于约1.75。