公开(公告)号：US20100121231A1

公开(公告)日：2010-05-13

申请号：US12576891

申请日：2009-10-09

申请人： Alan Y. Chow ,  George Y. McLean ,  Vincent Y. Chow ,  Jay Cech ,  Christopher M. Bonner ,  Vladimir Gelfandbein

发明人： Alan Y. Chow ,  George Y. McLean ,  Vincent Y. Chow ,  Jay Cech ,  Christopher M. Bonner ,  Vladimir Gelfandbein

IPC分类号： A61F9/00

CPC分类号： A61N1/36046 ,  A61H5/00 ,  A61N1/0543 ,  A61N2/06 ,  A61N2/12

摘要： Mechanically activated objects or devices for use in treating degenerative retinal diseases are provided. Such devices apply mechanical forces to tissues of an eye to effectuate treatment and are configured for chronic implantation (thereby applying chronic stimulation/irritation) in or on the eye. The devices may be configured for contact with a retina of the eye, preferably positioned in a subretinal space. Various embodiments comprise a moving member configured for chronic contact with at least a portion of the eye, which moving member is activated by an actuator. In some embodiments, the actuator may be distally located relative to the moving member. Alternatively, the moving member may be supported by a body member that, optionally, also supports the actuator.

摘要翻译： 提供用于治疗退行性视网膜疾病的机械活化物体或装置。 这样的装置将机械力施加到眼睛的组织以实现治疗，并且被配置为在眼睛中或眼睛上进行慢性植入（从而施加慢性刺激/刺激）。 所述装置可以被配置为与眼睛的视网膜接触，优选地定位在视网膜下空间中。 各种实施例包括构造成用于与眼睛的至少一部分慢性接触的移动构件，该移动构件由致动器致动。 在一些实施例中，致动器可以相对于移动构件向远侧定位。 或者，移动构件可以由主体构件支撑，其可选地还支撑致动器。

公开(公告)号：US07981062B2

公开(公告)日：2011-07-19

申请号：US12576891

申请日：2009-10-09

申请人： Alan Y. Chow ,  George Y. McLean ,  Vincent Y. Chow ,  Jay Cech ,  Christopher M. Bonner ,  Vladimir Gelfandbein

发明人： Alan Y. Chow ,  George Y. McLean ,  Vincent Y. Chow ,  Jay Cech ,  Christopher M. Bonner ,  Vladimir Gelfandbein

IPC分类号： A61H1/00

CPC分类号： A61N1/36046 ,  A61H5/00 ,  A61N1/0543 ,  A61N2/06 ,  A61N2/12

摘要： Mechanically activated objects or devices for use in treating degenerative retinal diseases are provided. Such devices apply mechanical forces to tissues of an eye to effectuate treatment and are configured for chronic implantation (thereby applying chronic stimulation/irritation) in or on the eye. The devices may be configured for contact with a retina of the eye, preferably positioned in a subretinal space. Various embodiments comprise a moving member configured for chronic contact with at least a portion of the eye, which moving member is activated by an actuator. In some embodiments, the actuator may be distally located relative to the moving member. Alternatively, the moving member may be supported by a body member that, optionally, also supports the actuator.

摘要翻译： 提供用于治疗退行性视网膜疾病的机械活化物体或装置。 这样的装置将机械力施加到眼睛的组织以实现治疗，并且被配置为在眼睛中或眼睛上进行慢性植入（从而施加慢性刺激/刺激）。 所述装置可以被配置为与眼睛的视网膜接触，优选地定位在视网膜下空间中。 各种实施例包括构造成用于与眼睛的至少一部分慢性接触的移动构件，该移动构件由致动器致动。 在一些实施例中，致动器可以相对于移动构件向远侧定位。 或者，移动构件可以由主体构件支撑，其可选地还支撑致动器。

公开(公告)号：US07610098B2

公开(公告)日：2009-10-27

申请号：US11313245

申请日：2005-12-20

申请人： George Y. McLean

发明人： George Y. McLean

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61F2/14 ,  A61F9/007

摘要： A retinal prosthesis that provides power control capabilities through the temporal integration of electrical charge is provided. The retinal prosthesis comprises at least one stimulating component, each stimulating component in turn comprising a photojunction element (e.g., a photodiode) in electrical communication with an electrode. A pulse generation circuit provides a reverse-bias signal and, from time to time, a pulsatile forward-bias signal to the photojunction element. During application of the reverse-bias signal, light incident upon the photojunction element causes electrical charge to be accumulated. Upon application of the pulsatile forward-bias signal, the accumulated electrical charge is injected via the electrode into retinal tissues, thereby stimulating the retina. By appropriately selecting the bias signal parameters, a sufficient amount of charge may be accumulated to ensure reaching stimulation thresholds. In this manner, control over stimulus currents may be improved while still retaining advantageous use of the eye's natural focusing and imaging capabilities.

摘要翻译： 提供了通过电荷的时间整合提供功率控制能力的视网膜假体。 视网膜假体包括至少一个刺激组分，每个刺激组分依次包含与电极电连通的光电耦合元件（例如，光电二极管）。 脉冲发生电路提供反向偏置信号，并且不时向光耦合元件提供脉冲正向偏置信号。 在施加反向偏置信号的过程中，入射到光电结元件上的光使电荷积聚。 在施加脉动正向偏置信号时，通过电极将累积的电荷注入视网膜组织，从而刺激视网膜。 通过适当选择偏置信号参数，可以累积足够量的电荷以确保达到刺激阈值。 以这种方式，可以改善对刺激电流的控制，同时仍然保持眼睛的自然聚焦和成像能力的有利使用。