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公开(公告)号：US08110398B2
公开(公告)日：2012-02-07
申请号：US12843706
申请日：2010-07-26
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
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2.发明授权Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals 有权稳定的细胞系和评估化学品胃肠道吸收的方法公开(公告)号：US08105828B2
公开(公告)日：2012-01-31
申请号：US12843536
申请日：2010-07-26
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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3.发明申请Stable Cell Lines and Methods for Evaluating Gastrointestinal Absorption of Chemicals 有权稳定的细胞系和评估化学品胃肠道吸收的方法公开(公告)号：US20080124734A1
公开(公告)日：2008-05-29
申请号：US11938065
申请日：2007-11-09
申请人： Albert J. Owen , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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4.发明授权Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals 有权稳定的细胞系和评估化学品胃肠道吸收的方法公开(公告)号：US07795019B2
公开(公告)日：2010-09-14
申请号：US11938065
申请日：2007-11-09
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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5.发明申请Stable Cell Lines and Methods for Evaluating Gastrointestinal Absorption of Chemicals 有权稳定的细胞系和评估化学品胃肠道吸收的方法公开(公告)号：US20100311082A1
公开(公告)日：2010-12-09
申请号：US12843706
申请日：2010-07-26
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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公开(公告)号：US20120142008A1
公开(公告)日：2012-06-07
申请号：US13347544
申请日：2012-01-10
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
IPC分类号： C12Q1/02 , C12Q1/68 , G01N33/566 , C12N5/10
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
摘要翻译： 提供了用于干扰表达这种蛋白质的细胞中膜外排转运蛋白表达的核酸和载体。 还提供了包含这种核酸和载体的细胞和细胞系。 还提供了用于筛选动物中用于胃肠道吸收的化学物质和生物分子的方法，以及用于实践这些方法的试剂盒。
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公开(公告)号：US20100317049A1
公开(公告)日：2010-12-16
申请号：US12843536
申请日：2010-07-26
申请人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
发明人： Albert J. Owen, III , Ismael J. Hidalgo , Jibin Li , Wei Zhang
CPC分类号： C12N15/1138 , C12N15/111 , C12N2310/14 , C12N2320/12 , G01N33/502
摘要： Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing such methods are also provided.
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公开(公告)号：US08133192B2
公开(公告)日：2012-03-13
申请号：US12219417
申请日：2008-07-22
申请人： Bingyuan Kang , Jibin Li , Haoheng Luan , Zengxian Wang , Qingyong Chen , Ye Zhu
发明人： Bingyuan Kang , Jibin Li , Haoheng Luan , Zengxian Wang , Qingyong Chen , Ye Zhu
IPC分类号： A61H7/00
CPC分类号： A61H23/0254 , A61H1/005 , A61H9/0078 , A61H2201/0103 , A61H2201/0149 , A61H2201/164 , A61H2201/1678 , A61H2205/10 , A61H2205/106 , A61H2205/12
摘要： The present invention relates to a massage device, and more particularly, to a leg and foot massage device capable of achieving foot swing. The device includes an electrical machinery deceleration element, a wobbler machine element and an air inflatable bag massage element. The electrical machinery deceleration element drives the air inflatable bag massage element through the wobbler machine element, and the electrical machinery realizes the one-off deceleration. Therefore mechanical transmission steps are simplified and transmission noise obviously dropped, wobbler machine element cooperates with air inflatable bags' inflation and deflation, generating many kinds of different massage motions and obtaining a comprehensive massage effect on leg and feet muscles and joints.
摘要翻译： 按摩装置技术领域本发明涉及一种按摩装置，更具体地，涉及能够实现足部摆动的腿部和足部按摩装置。 该装置包括电机减速元件，摇摆机器元件和空气可充气袋按摩元件。 电机减速元件通过摆动机构驱动空气充气袋按摩元件，电机实现一次性减速。 因此机械传动步骤简化，传动噪声明显下降，摆动机构与空气充气袋充气通气配合，产生多种不同的按摩动作，对腿脚肌肉和关节得到全面的按摩效果。
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公开(公告)号：US20100047907A1
公开(公告)日：2010-02-25
申请号：US12544118
申请日：2009-08-19
申请人： Jibin Li , Paula S. Kardos , Samantha Mackenzie Allen , Ying Wang
发明人： Jibin Li , Paula S. Kardos , Samantha Mackenzie Allen , Ying Wang
IPC分类号： C12N5/08
CPC分类号： C12M25/04
摘要： Described herein are tissue culture plates with permeable tissue culture plate inserts therein, which provides the tissue culture plates with apical chamber and a basolateral chambers, wherein cells are deposited on the permeable tissue culture inserts and essentially all of tissue culture medium has been removed from the apical chambers of the tissue culture plates and the basolateral chambers of the tissue culture plates contain a solidifiable form of cell culture medium. Also described are cells that can be deposited and grown on the described tissue culture inserts, methods for transporting a tissue culture plate with a permeable tissue culture plate insert therein on which cells are deposited. Also described is a kit for transporting the tissue culture plates described above, and corresponding methods of use.
摘要翻译： 本文描述的是其中具有可渗透组织培养板插入物的组织培养板，其向组织培养板提供顶端室和基底外侧室，其中细胞沉积在可渗透组织培养插入物上，并且基本上所有的组织培养基已经从 组织培养板的顶端室和组织培养板的基底外侧室含有可固化形式的细胞培养基。 还描述了可以在所述组织培养插入物上沉积和生长的细胞，其中沉积有细胞的可渗透的组织培养板插入物的组织培养板的传送方法。 还描述了用于运输上述组织培养板的试剂盒和相应的使用方法。
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公开(公告)号：US20090036810A1
公开(公告)日：2009-02-05
申请号：US12219417
申请日：2008-07-22
申请人： Bingyuan Kang , Jibin Li , Haoheng Luan , Zengxian Wang , Qingyong Chen , Ye Zhu
发明人： Bingyuan Kang , Jibin Li , Haoheng Luan , Zengxian Wang , Qingyong Chen , Ye Zhu
IPC分类号： A61H7/00
CPC分类号： A61H23/0254 , A61H1/005 , A61H9/0078 , A61H2201/0103 , A61H2201/0149 , A61H2201/164 , A61H2201/1678 , A61H2205/10 , A61H2205/106 , A61H2205/12
摘要： The present invention relates to a massage device, and more particularly, to a leg and foot massage device capable of achieving foot swing. The device includes an electrical machinery deceleration element, a wobbler machine element and an air inflatable bag massage element. The electrical machinery deceleration element drives the air inflatable bag massage element through the wobbler machine element, and the electrical machinery realizes the one-off deceleration. Therefore mechanical transmission steps are simplified and transmission noise obviously dropped, wobbler machine element cooperates with air inflatable bags' inflation and deflation, generating many kinds of different massage motions and obtaining a comprehensive massage effect on leg and feet muscles and joints.
摘要翻译： 按摩装置技术领域本发明涉及一种按摩装置，更具体地，涉及能够实现足部摆动的腿部和足部按摩装置。 该装置包括电机减速元件，摇摆机器元件和空气可充气袋按摩元件。 电机减速元件通过摆动机构驱动空气充气袋按摩元件，电机实现一次性减速。 因此机械传动步骤简化，传动噪声明显下降，摆动机构与空气充气袋充气通气配合，产生多种不同的按摩动作，对腿脚肌肉和关节得到全面的按摩效果。
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