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    Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
    1.
    发明授权
    Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways 有权
    用于检测间变性大细胞淋巴瘤信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US07973134B2

    公开(公告)日：2011-07-05

    申请号：US11503096

    申请日：2006-08-11

    申请人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    发明人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    IPC分类号： C07K16/00 ,  C07K16/18

    CPC分类号： G01N33/6842 ,  C07K16/44

    摘要： The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein Kinases (including Receptor Tyrosine Kinases), Adaptor/Scaffold Proteins, Cellular Metabolism or Miscellaneous Enzymes, Oxidoreductases, Transcription Factors, Cytoskeletal Proteins, Translation Initiation Complexes, RNA Binding Proteins, Proteases, Acetyltransferases, G protein regulators/GTPases, Helicases, Apoptosis/Cell Cycle Regulation proteins, and Hydrolases.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的211个新的磷酸化位点和涉及ALK-NPM易位/融合的间变性大细胞淋巴瘤（ALCL）的途径，并且为磷酸化位点特异性抗体和重同位素标记的肽（AQUA肽）提供了 这些磷酸化位点/蛋白质的选择性检测和定量，以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是以下蛋白质类型发生的位点：蛋白激酶（包括受体酪氨酸激酶），适配器/支架蛋白，细胞代谢或其他酶，氧化还原酶，转录因子，细胞骨架蛋白，翻译起始复合物，RNA结合蛋白， 蛋白酶，乙酰转移酶，G蛋白调节剂/ GTP酶，Helicases，细胞凋亡/细胞周期调节蛋白和水解酶。

    Reagents for the detection of protein phosphorylation in c-Src signaling pathways
    2.
    发明授权
    Reagents for the detection of protein phosphorylation in c-Src signaling pathways 有权
    用于检测c-Src信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US07939636B2

    公开(公告)日：2011-05-10

    申请号：US11503335

    申请日：2006-08-11

    申请人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    发明人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    IPC分类号： G07K16/00 ,  G07K16/18

    CPC分类号： G01N33/5041 ,  C07K16/18 ,  C07K16/3015 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/34 ,  G01N2333/91215

    摘要： The invention discloses 102 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of c-Src kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Actin Binding proteins, Cytoskeletal proteins, G protein/GTPase Activating protein/Guanine Nucleotide Exchange Factor proteins, Helicases, RNA Binding proteins, Transcription/Translation Factor or Initiation Complex proteins, Cellular Metabolism Enzymes, and Vesicle proteins.

    摘要翻译： 本发明公开了在c-Src激酶下游的信号转导蛋白和途径中鉴定的102个新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质 ，以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是以下蛋白质类型的位点：适配器/支架蛋白，肌动蛋白结合蛋白，细胞骨架蛋白，G蛋白/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，Helicases，RNA结合蛋白，转录因子/翻译因子或 起始复合蛋白​​，细胞代谢酶和囊泡蛋白。

    Reagents for the detection of protein phosphorylation in c-Src signaling pathways
    3.
    发明申请
    Reagents for the detection of protein phosphorylation in c-Src signaling pathways 有权
    用于检测c-Src信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20080038752A1

    公开(公告)日：2008-02-14

    申请号：US11503335

    申请日：2006-08-11

    申请人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    发明人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    IPC分类号： G01N33/542 ,  G01N33/53

    CPC分类号： G01N33/5041 ,  C07K16/18 ,  C07K16/3015 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/34 ,  G01N2333/91215

    摘要： The invention discloses 102 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of c-Src kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Actin Binding proteins, Cytoskeletal proteins, G protein/GTPase Activating protein/Guanine Nucleotide Exchange Factor proteins, Helicases, RNA Binding proteins, Transcription/Translation Factor or Initiation Complex proteins, Cellular Metabolism Enzymes, and Vesicle proteins.

    摘要翻译： 本发明公开了在c-Src激酶下游的信号转导蛋白和途径中鉴定的102个新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质 ，以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是以下蛋白质类型的位点：适配器/支架蛋白，肌动蛋白结合蛋白，细胞骨架蛋白，G蛋白/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，Helicases，RNA结合蛋白，转录因子/翻译因子或 起始复合蛋白​​，细胞代谢酶和囊泡蛋白。

    Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
    4.
    发明申请
    Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways 有权
    用于检测间变性大细胞淋巴瘤信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20070072235A1

    公开(公告)日：2007-03-29

    申请号：US11503096

    申请日：2006-08-11

    申请人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    发明人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6842 ,  C07K16/44

    摘要： The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein Kinases (including Receptor Tyrosine Kinases), Adaptor/Scaffold Proteins, Cellular Metabolism or Miscellaneous Enzymes, Oxidoreductases, Transcription Factors, Cytoskeletal Proteins, Translation Initiation Complexes, RNA Binding Proteins, Proteases, Acetyltransferases, G protein regulators/GTPases, Helicases, Apoptosis/Cell Cycle Regulation proteins, and Hydrolases.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的211个新的磷酸化位点和涉及ALK-NPM易位/融合的间变性大细胞淋巴瘤（ALCL）的途径，并且为磷酸化位点特异性抗体和重同位素标记的肽（AQUA肽）提供了 这些磷酸化位点/蛋白质的选择性检测和定量，以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是以下蛋白质类型发生的位点：蛋白激酶（包括受体酪氨酸激酶），适配器/支架蛋白，细胞代谢或其他酶，氧化还原酶，转录因子，细胞骨架蛋白，翻译起始复合物，RNA结合蛋白， 蛋白酶，乙酰转移酶，G蛋白调节剂/ GTP酶，Helicases，细胞凋亡/细胞周期调控蛋白和水解酶。

    Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
    5.
    发明申请
    Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways 有权
    用于检测T细胞受体信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20070059845A1

    公开(公告)日：2007-03-15

    申请号：US11503336

    申请日：2006-08-11

    申请人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    发明人： Albrecht Moritz ,  Kimberly Lee ,  John Rush ,  Roberto Polakiewicz

    IPC分类号： G01N33/543

    CPC分类号： G01N33/6872 ,  C12Q1/25 ,  C12Q1/485 ,  G01N33/6842

    摘要： The invention discloses 95 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of the T-cell receptor, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Adhesion proteins, Calcium-binding proteins, Cell Cycle Regulation or Channel proteins, Chaperones, Cofactor proteins, Cytoskeletal proteins, DNA Binding proteins, G protein or GTPase Activating proteins, Ligases, Lipid Kinases and Binding proteins, Oxidoreductases, Protein Kinases, Protein Phosphatases, Receptor proteins, RNA Binding proteins, Transcription Factor/Initiation Complex proteins, Transcription Coactivator/Corepressor proteins, Translation Initiation Complex proteins, Ubitquitin Conjugating System proteins, and Vesicle proteins.

    摘要翻译： 本发明公开了在T细胞受体下游的信号转导蛋白和途径中鉴定的95个新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/ 蛋白质，以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：肌动蛋白结合蛋白，衔接/支架蛋白，粘附蛋白，钙结合蛋白，细胞周期调节或通道蛋白，伴侣蛋白，辅因子蛋白，细胞骨架蛋白，DNA结合蛋白， G蛋白或GTPase激活蛋白，连接酶，脂质激酶和结合蛋白，氧化还原酶，蛋白激酶，蛋白磷酸酶，受体蛋白，RNA结合蛋白，转录因子/起始复合蛋白​​，转录共激活因子/ Corepressor蛋白，翻译起始复合蛋白​​，Ubitquitin缀合 系统蛋白和囊泡蛋白。