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    Combination Therapies for Treating Metabolic Disorders
    1.
    发明申请
    Combination Therapies for Treating Metabolic Disorders 审中-公开
    治疗代谢紊乱的组合疗法

    公开(公告)号：US20100239552A1

    公开(公告)日：2010-09-23

    申请号：US12724756

    申请日：2010-03-16

    申请人： Eric Mayoux ,  Luc Marti Clauzel ,  Silvia Garcia-Vicente ,  Marta Serrano Munoz ,  Antonio Zorzano Olarte ,  Alec Mian

    发明人： Eric Mayoux ,  Luc Marti Clauzel ,  Silvia Garcia-Vicente ,  Marta Serrano Munoz ,  Antonio Zorzano Olarte ,  Alec Mian

    IPC分类号： A61K31/385 ,  A61K31/05 ,  A61K31/357 ,  A61K31/198 ,  A61K31/185 ,  A61K31/10 ,  A61K31/122 ,  A61K31/09 ,  A61K31/121 ,  A61K31/192 ,  A61K31/60 ,  A61K31/618 ,  A61K31/603 ,  A61K31/167 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P3/04 ,  A61P29/00 ,  A61P39/06

    CPC分类号： A61K31/198 ,  A61K31/00 ,  A61K31/192 ,  A61K31/196 ,  A61K31/385 ,  A61K31/60 ,  A61K45/06 ,  A61K2300/00

    摘要： This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier. The combinations and compositions of this invention are useful as methods for treating metabolic disorders including diabetes, particularly Type I and Type II diabetes, as well as diseases and disorders associated with diabetes, including but not limited to atherosclerosis, cardiovascular disease, inflammatory disorders, nephropathy, neuropathy, retinopathy, β-cell dysfunction, dyslipidemia, LADA, metabolic syndrome, hyperglycemia, insulin resistance, and/or chronic obstructive pulmonary disease in a mammal, particularly a diabetic mammal, and specifically a human patient. This invention is particularly directed to pharmaceutical compositions comprising an lipoic acid, one or more anti-inflammatories selected from the group consisting of diflunisal, diclofenac, dexibuprofen, dexketoprofen, naproxen, and salicylate, and optionally one or more pharmaceutically acceptable carriers. The compositions of this invention are useful as methods for treating metabolic disorders including type II diabetes, insulin resistance, beta-cell dysfunction, and hyperglycemia in a patient, particularly a diabetic patient.

    摘要翻译： 本发明涉及包含抗氧化剂，抗炎剂和任选的至少一种其它用于治疗代谢紊乱的其它抗糖尿病药物的药物组合。 本发明还包括药学上可接受的组合物，其包含抗氧化剂，抗炎剂，任选的至少一种其它抗糖尿病药物和至少一种药学上可接受的载体。 本发明的组合和组合物可用作治疗代谢紊乱的方法，包括糖尿病，特别是I型和II型糖尿病，以及与糖尿病相关的疾病和病症，包括但不限于动脉粥样硬化，心血管疾病，炎症性疾病，肾病 ，特别是糖尿病哺乳动物，特别是人类患者的神经病，视网膜病变，细胞功能障碍，血脂异常，LADA，代谢综合征，高血糖症，胰岛素抵抗和/或慢性阻塞性肺疾病。 本发明特别涉及药物组合物，其包含硫辛酸，一种或多种选自二氟尼柳，双氯芬酸，右布洛芬，右克洛芬，萘普生和水杨酸酯的抗炎剂，以及任选的一种或多种药学上可接受的载体。 本发明的组合物可用作治疗患者，特别是糖尿病患者中的II型糖尿病，胰岛素抵抗，β细胞功能障碍和高血糖症的代谢疾病的方法。