利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

30 条记录 (耗时 0.041 秒)

    Combination Therapies for Treating Metabolic Disorders
    1.
    发明申请
    Combination Therapies for Treating Metabolic Disorders 审中-公开
    治疗代谢紊乱的组合疗法

    公开(公告)号：US20100239552A1

    公开(公告)日：2010-09-23

    申请号：US12724756

    申请日：2010-03-16

    申请人： Eric Mayoux ,  Luc Marti Clauzel ,  Silvia Garcia-Vicente ,  Marta Serrano Munoz ,  Antonio Zorzano Olarte ,  Alec Mian

    发明人： Eric Mayoux ,  Luc Marti Clauzel ,  Silvia Garcia-Vicente ,  Marta Serrano Munoz ,  Antonio Zorzano Olarte ,  Alec Mian

    IPC分类号： A61K31/385 ,  A61K31/05 ,  A61K31/357 ,  A61K31/198 ,  A61K31/185 ,  A61K31/10 ,  A61K31/122 ,  A61K31/09 ,  A61K31/121 ,  A61K31/192 ,  A61K31/60 ,  A61K31/618 ,  A61K31/603 ,  A61K31/167 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P3/04 ,  A61P29/00 ,  A61P39/06

    CPC分类号： A61K31/198 ,  A61K31/00 ,  A61K31/192 ,  A61K31/196 ,  A61K31/385 ,  A61K31/60 ,  A61K45/06 ,  A61K2300/00

    摘要： This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier. The combinations and compositions of this invention are useful as methods for treating metabolic disorders including diabetes, particularly Type I and Type II diabetes, as well as diseases and disorders associated with diabetes, including but not limited to atherosclerosis, cardiovascular disease, inflammatory disorders, nephropathy, neuropathy, retinopathy, β-cell dysfunction, dyslipidemia, LADA, metabolic syndrome, hyperglycemia, insulin resistance, and/or chronic obstructive pulmonary disease in a mammal, particularly a diabetic mammal, and specifically a human patient. This invention is particularly directed to pharmaceutical compositions comprising an lipoic acid, one or more anti-inflammatories selected from the group consisting of diflunisal, diclofenac, dexibuprofen, dexketoprofen, naproxen, and salicylate, and optionally one or more pharmaceutically acceptable carriers. The compositions of this invention are useful as methods for treating metabolic disorders including type II diabetes, insulin resistance, beta-cell dysfunction, and hyperglycemia in a patient, particularly a diabetic patient.

    摘要翻译： 本发明涉及包含抗氧化剂，抗炎剂和任选的至少一种其它用于治疗代谢紊乱的其它抗糖尿病药物的药物组合。 本发明还包括药学上可接受的组合物，其包含抗氧化剂，抗炎剂，任选的至少一种其它抗糖尿病药物和至少一种药学上可接受的载体。 本发明的组合和组合物可用作治疗代谢紊乱的方法，包括糖尿病，特别是I型和II型糖尿病，以及与糖尿病相关的疾病和病症，包括但不限于动脉粥样硬化，心血管疾病，炎症性疾病，肾病 ，特别是糖尿病哺乳动物，特别是人类患者的神经病，视网膜病变，细胞功能障碍，血脂异常，LADA，代谢综合征，高血糖症，胰岛素抵抗和/或慢性阻塞性肺疾病。 本发明特别涉及药物组合物，其包含硫辛酸，一种或多种选自二氟尼柳，双氯芬酸，右布洛芬，右克洛芬，萘普生和水杨酸酯的抗炎剂，以及任选的一种或多种药学上可接受的载体。 本发明的组合物可用作治疗患者，特别是糖尿病患者中的II型糖尿病，胰岛素抵抗，β细胞功能障碍和高血糖症的代谢疾病的方法。

    Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
    7.
    发明授权
    Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders 有权
    硫代碳酸酯作为抗炎和抗氧化化合物，可用于治疗代谢紊乱

    公开(公告)号：US08466197B2

    公开(公告)日：2013-06-18

    申请号：US13235031

    申请日：2011-09-16

    申请人： Julio Cesar Castro Palomino Laria ,  Luc Marti Clauzel ,  Antonio Zorzano Olarte ,  Silvia Garcia Vicente ,  Alec Mian

    发明人： Julio Cesar Castro Palomino Laria ,  Luc Marti Clauzel ,  Antonio Zorzano Olarte ,  Silvia Garcia Vicente ,  Alec Mian

    IPC分类号： A61K31/265 ,  C07C329/06

    CPC分类号： C07C329/06

    摘要： The invention is directed to thiocarbonate compounds of Formula (I)-(III) and methods of treating atherosclerosis, neuropathy, nephropathy, retinopathy, inflammatory disorders, COPD, cardiovascular diseases, metabolic disorders, type I diabetes mellitus, type II diabetes mellitus, LADA, Wolfram Syndrome 1, Wolcott-Rallison syndrome, metabolic syndrome, dyslipidemia, hyperglycemia, or insulin resistance. The compounds of the invention are also useful for protecting pancreatic beta-cells and for reducing free fatty acids, triglycerides, advanced glycated end products, ROS, lipid peroxidation, tissue and plasma TNFalpha and IL6 levels, or for delaying or preventing cardiovascular complications associated with atherosclerosis.

    摘要翻译： 本发明涉及式（I） - （III）的硫代碳酸酯化合物和治疗动脉粥样硬化，神经病，肾病，视网膜病，炎症性疾病，COPD，心血管疾病，代谢紊乱，I型糖尿病，II型糖尿病，LADA ，Wolfram综合征1，Wolcott-Rallison综合征，代谢综合征，血脂异常，高血糖或胰岛素抵抗。 本发明的化合物还可用于保护胰腺β-细胞和用于减少游离脂肪酸，甘油三酯，晚期糖基化终产物，ROS，脂质过氧化，组织和血浆TNFalpha和IL6水平，或用于延迟或预防与 动脉粥样硬化。

    Thiocarbonates as Anti-Inflammatory and Antioxidant Compounds Useful For Treating Metabolic Disorders
    8.
    发明申请
    Thiocarbonates as Anti-Inflammatory and Antioxidant Compounds Useful For Treating Metabolic Disorders 有权
    硫代碳酸酯作为抗炎和抗氧化剂可用于治疗代谢紊乱

    公开(公告)号：US20120149769A1

    公开(公告)日：2012-06-14

    申请号：US13235031

    申请日：2011-09-16

    申请人： Julio Cesar Castro Palomino Laria ,  Luc Marti Clauzel ,  Antonio Zorzano Olarte ,  Silvia Garcia Vicente ,  Alec Mian

    发明人： Julio Cesar Castro Palomino Laria ,  Luc Marti Clauzel ,  Antonio Zorzano Olarte ,  Silvia Garcia Vicente ,  Alec Mian

    IPC分类号： A61K31/265 ,  A61P3/00 ,  A61P37/06 ,  A61P3/06 ,  C07C329/06 ,  A61P3/10

    CPC分类号： C07C329/06

    摘要： The invention is directed to thiocarbonate compounds of Formula (I)-(III) and methods of treating atherosclerosis, neuropathy, nephropathy, retinopathy, inflammatory disorders, COPD, cardiovascular diseases, metabolic disorders, type I diabetes mellitus, type II diabetes mellitus, LADA, Wolfram Syndrome 1, Wolcott-Rallison syndrome, metabolic syndrome, dyslipidemia, hyperglycemia, or insulin resistance. The compounds of the invention are also useful for protecting pancreatic beta-cells and for reducing free fatty acids, triglycerides, advanced glycated end products, ROS, lipid peroxidation, tissue and plasma TNFalpha and IL6 levels, or for delaying or preventing cardiovascular complications associated with atherosclerosis.

    摘要翻译： 本发明涉及式（I） - （III）的硫代碳酸酯化合物和治疗动脉粥样硬化，神经病，肾病，视网膜病，炎症性疾病，COPD，心血管疾病，代谢紊乱，I型糖尿病，II型糖尿病，LADA ，Wolfram综合征1，Wolcott-Rallison综合征，代谢综合征，血脂异常，高血糖或胰岛素抵抗。 本发明的化合物还可用于保护胰腺β-细胞和用于减少游离脂肪酸，甘油三酯，晚期糖基化终产物，ROS，脂质过氧化，组织和血浆TNFalpha和IL6水平，或用于延迟或预防与 动脉粥样硬化。

    Decorative luminous panel assembly and its support
    9.
    发明授权
    Decorative luminous panel assembly and its support 失效
    装饰发光面板组件及其支撑

    公开(公告)号：US07021011B2

    公开(公告)日：2006-04-04

    申请号：US11088043

    申请日：2005-03-23

    申请人： Alec Mian ,  Julie Callahan

    发明人： Alec Mian ,  Julie Callahan

    IPC分类号： E06B7/00

    CPC分类号： G09F19/12 ,  E04B9/04 ,  E04B9/18 ,  E04B9/32 ,  F21S2/00 ,  F21V3/0625 ,  F21V5/00 ,  F21V13/02 ,  F21V17/101 ,  F21V17/104 ,  G09F13/08

    摘要： The decorative luminous panel assembly and its support comprises a panel of translucent synthetic material bearing decorative designs and capable of receiving the illumination from a light source incorporated in the support, said panel carrying a plurality of thread-like elements of transparent synthetic material, fixed by one end to the panel at the rear face thereof, that is to say, on the unseen face, and which are capable of being fixed by the other end on the support, the rear face of the panel making firm contact against a plurality of supporting appendages of the support, which have a very pointed end, so that the contact with the panel occurs on an extraordinarily reduced surface, practically invisible from the exposed side of the translucent panel.

    摘要翻译： 装饰性发光板组件及其支撑件包括具有装饰设计的半透明合成材料的面板，并且能够接收来自结合在支撑件中的光源的照明，所述面板承载多个透明合成材料的线状元件，由 一端在面板后面，也就是说，在看不见的面上，另一端能够固定在支架上，面板的后表面与多个支撑件 支撑件的附件具有非常尖的端部，使得与面板的接触发生在非常简单的表面上，实际上从半透明面板的暴露侧看不见。