利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

23 条记录 (耗时 0.049 秒)

    Antibodies to &agr;v&bgr;3 integrin
    7.
    发明授权
    Antibodies to &agr;v&bgr;3 integrin 失效
    抗体为alphavbeta3整合素

    公开(公告)号：US06369204B1

    公开(公告)日：2002-04-09

    申请号：US09560743

    申请日：2000-04-28

    申请人： Kyung Jin Kim ,  Michael A. Horton ,  Sarah C. Bodary ,  Anan Chuntharapai

    发明人： Kyung Jin Kim ,  Michael A. Horton ,  Sarah C. Bodary ,  Anan Chuntharapai

    IPC分类号： C12P2108

    CPC分类号： C07K16/2848 ,  A61K38/00 ,  Y10S530/867

    摘要： The invention relates to monoclonal antibodies to the &agr;v&bgr;3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on &agr;v&bgr;3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.

    摘要翻译： 本发明涉及已知在破骨细胞表面上大量表达的α受体α整联蛋白受体的单克隆抗体，因此与骨吸收有关。 据信所公开的单克隆抗体识别出在α2β3上的独特表位，并且可用于治疗与过量骨吸收和/或抑制肿瘤细胞生长相关的病症。

    COMPOSITIONS AND METHODS FOR TREATMENT
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT 审中-公开
    组合物和治疗方法

    公开(公告)号：US20080175842A1

    公开(公告)日：2008-07-24

    申请号：US11754196

    申请日：2007-05-25

    申请人： Sarah C. Bodary ,  Karen L. Fisher

    发明人： Sarah C. Bodary ,  Karen L. Fisher

    IPC分类号： A61K39/395 ,  C12N5/06 ,  A61K31/70 ,  A61P43/00

    CPC分类号： C07K14/70596 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2896 ,  C12N2799/026

    摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of an ADAM8 gene that is amplified in the genome of tumor cells. Such gene amplification is associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contributes to tumorigenesis. Accordingly, the ADAM8 protein encoded by the amplified gene is a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and acts as a predictor of the prognosis of tumor treatment.

    摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的ADAM8基因的鉴定。 与相同组织类型的正常细胞相比，这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的ADAM8蛋白是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且作为肿瘤治疗预后的预测因子。