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公开(公告)号：US20080175842A1
公开(公告)日：2008-07-24
申请号：US11754196
申请日：2007-05-25
申请人： Sarah C. Bodary , Karen L. Fisher
发明人： Sarah C. Bodary , Karen L. Fisher
IPC分类号： A61K39/395 , C12N5/06 , A61K31/70 , A61P43/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/505 , C07K16/2896 , C12N2799/026
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of an ADAM8 gene that is amplified in the genome of tumor cells. Such gene amplification is associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contributes to tumorigenesis. Accordingly, the ADAM8 protein encoded by the amplified gene is a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and acts as a predictor of the prognosis of tumor treatment.
摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的ADAM8基因的鉴定。 与相同组织类型的正常细胞相比，这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的ADAM8蛋白是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且作为肿瘤治疗预后的预测因子。
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公开(公告)号：US07226596B2
公开(公告)日：2007-06-05
申请号：US10226844
申请日：2002-08-22
申请人： Sarah C. Bodary , Karen L. Fisher
发明人： Sarah C. Bodary , Karen L. Fisher
IPC分类号： A61K39/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/505 , C07K16/2896 , C12N2799/026
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of an ADAM8 gene that is amplified in the genome of tumor cells. Such gene amplification is associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contributes to tumorigenesis. Accordingly, the ADAM8 protein encoded by the amplified gene is a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and acts as a predictor of the prognosis of tumor treatment.
摘要翻译： 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的ADAM8基因的鉴定。 与相同组织类型的正常细胞相比，这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生。 因此，由扩增的基因编码的ADAM8蛋白是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且作为肿瘤治疗预后的预测因子。
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3.发明申请公开(公告)号：US20110142841A1
公开(公告)日：2011-06-16
申请号：US12589398
申请日：2009-10-22
申请人： Alexander Abbas , Sarah C. Bodary , Hilary Clark , Jill R. Schoenfeld , P. Mickey Williams , William I. Wood , Thomas D. Wu
发明人： Alexander Abbas , Sarah C. Bodary , Hilary Clark , Jill R. Schoenfeld , P. Mickey Williams , William I. Wood , Thomas D. Wu
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , C07K14/00 , C07K16/00 , G01N33/53 , A61K39/00 , A61P37/06
CPC分类号： C07K14/435 , A61K38/00
摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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4.发明申请公开(公告)号：US20090181024A1
公开(公告)日：2009-07-16
申请号：US11537270
申请日：2006-09-29
申请人： Daryl T. Baldwin , Sarah C. Bodary , Andrew C. Chan , Hilary Clark , Janet K. Jackman , William I. Wood
发明人： Daryl T. Baldwin , Sarah C. Bodary , Andrew C. Chan , Hilary Clark , Janet K. Jackman , William I. Wood
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , C07K14/00 , C07K19/00 , C07K16/18 , A61K38/16 , G01N33/536 , C12Q1/68 , C12Q1/02 , A61P37/02
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C12N2799/026 , C12Q1/6883 , C12Q2600/158 , G01N2500/10 , G01N2800/065 , G01N2800/205 , G01N2800/24
摘要： The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.
摘要翻译： 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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公开(公告)号：US06369204B1
公开(公告)日：2002-04-09
申请号：US09560743
申请日：2000-04-28
IPC分类号： C12P2108
CPC分类号： C07K16/2848 , A61K38/00 , Y10S530/867
摘要： The invention relates to monoclonal antibodies to the &agr;v&bgr;3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on &agr;v&bgr;3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.
摘要翻译： 本发明涉及已知在破骨细胞表面上大量表达的α受体α整联蛋白受体的单克隆抗体，因此与骨吸收有关。 据信所公开的单克隆抗体识别出在α2β3上的独特表位，并且可用于治疗与过量骨吸收和/或抑制肿瘤细胞生长相关的病症。
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公开(公告)号：US5837486A
公开(公告)日：1998-11-17
申请号：US445443
申请日：1995-05-19
IPC分类号： C12N15/09 , A61K38/00 , A61P43/00 , C07K14/00 , C07K14/705 , C07K16/00 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/00 , C12P21/02 , C12R1/91
CPC分类号： C07K16/00 , C07K14/705 , C07K14/70553 , C07K14/70557 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/33
摘要： Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.
摘要翻译： 提供了用于在重组宿主细胞中制备离散编码的异源多聚体多肽受体的生物活性可溶性变体的方法。 这些变体通过跨膜修饰的异源多聚体受体的重组转化体的分泌合成。 优选的受体是细胞外基质，细胞表面或血浆蛋白结合受体，例如GPIIb-IIIa。
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公开(公告)号：US5726037A
公开(公告)日：1998-03-10
申请号：US444792
申请日：1995-05-19
IPC分类号： C12N15/09 , A61K38/00 , A61P43/00 , C07K14/00 , C07K14/705 , C07K16/00 , C07K19/00 , C12N5/10 , C12N15/12 , C12P21/00 , C12P21/02 , C12R1/91
CPC分类号： C07K16/00 , C07K14/705 , C07K14/70553 , C07K14/70557 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/33
摘要： Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.
摘要翻译： 提供了用于在重组宿主细胞中制备离散编码的异源多聚体多肽受体的生物活性可溶性变体的方法。 这些变体通过跨膜修饰的异源多聚体受体的重组转化体的分泌合成。 优选的受体是细胞外基质，细胞表面或血浆蛋白结合受体，例如GPIIb-IIIa。
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8.发明授权Benzofurane derivatives, their preparation process, their use as medicaments and the pharmaceutical compositions containing them 失效苯并呋喃衍生物，其制备方法，它们作为药物的用途以及含有它们的药物组合物公开(公告)号：US06586442B2
公开(公告)日：2003-07-01
申请号：US10180253
申请日：2002-06-26
申请人： Denis Carniato , Jean-Francois Gourvest , Jochen Knolle , Anurschirwan Peyman , Sarah C. Bodary , Thomas R. Gadek
发明人： Denis Carniato , Jean-Francois Gourvest , Jochen Knolle , Anurschirwan Peyman , Sarah C. Bodary , Thomas R. Gadek
IPC分类号： A61K31505
CPC分类号： C07D405/12
摘要： A compound of the formula wherein the substituents are as defined in the specification and its pharmaceutically acceptable salts and it prodrug useful for treating osteoporosis.
摘要翻译： 取代基中的取代基的化合物如说明书及其药学上可接受的盐所定义，并且其用于治疗骨质疏松症的前药。
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9.发明授权Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them 有权三环化合物，其制备方法和该方法的中间体，它们作为药物的用途和含有它们的药物组合物公开(公告)号：US06459001B1
公开(公告)日：2002-10-01
申请号：US09769018
申请日：2001-01-25
申请人： Serge Bernard , Denis Carniato , Jean-Francois Gourvest , Jean-Georges Teutsch , Jochen Knolle , Hans-Ulrich Stilz , Volkmar Wehner , Sarah C. Bodary , Thomas R. Gadek , Robert S. McDowell , Robert M. Pitti
发明人： Serge Bernard , Denis Carniato , Jean-Francois Gourvest , Jean-Georges Teutsch , Jochen Knolle , Hans-Ulrich Stilz , Volkmar Wehner , Sarah C. Bodary , Thomas R. Gadek , Robert S. McDowell , Robert M. Pitti
IPC分类号： C07C25182
CPC分类号： C07D239/18 , C07C45/516 , C07C45/63 , C07C45/673 , C07C45/71 , C07C49/747 , C07C49/755 , C07C281/12 , C07C281/18 , C07C337/08 , C07C2603/30 , C07D233/52 , C07C49/753
摘要： The subject of the invention is the products of formula (I): in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well as the addition salts with acids and bases and the esters, their preparation process and the intermediates of this process, their use as medicines and the pharmaceutical compositions containing them.
摘要翻译： 本发明的主题是式（I）的产物：其中R1，R2，R3，R4，R5和G如说明书中所定义，虚线代表任选的第二键，以及与 酸和碱和酯，它们的制备方法和该方法的中间体，它们作为药物的用途和含有它们的药物组合物。
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公开(公告)号：US5652109A
公开(公告)日：1997-07-29
申请号：US432542
申请日：1995-05-02
IPC分类号： G01N33/53 , A61K38/00 , A61K47/48 , C07K14/705 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , A61K39/395 , C12N5/00
CPC分类号： C07K16/2848 , A61K38/00 , Y10S530/867
摘要： The invention relates to monoclonal antibodies to the .alpha.v.beta.3 integrin receptor known to be expressed in large amounts on the surface of osteoclasts and accordingly, associated with bone resorption. The disclosed monoclonal antibodies are believed to recognize unique epitopes on .alpha.v.beta.3 and are useful in the treatment of conditions associated with excessive bone resorption and/or in the inhibition of tumor cell growth.
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