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公开(公告)号：US5698003A
公开(公告)日：1997-12-16
申请号：US575025
申请日：1995-12-19
CPC分类号： C05G3/08 , C05C9/00 , Y10S71/902
摘要： Improved solvent systems for the formulation of N-alkyl thiophosphoric triamide urease inhibitors. These formulations enable the preparation of stable concentrated solutions of N-alkyl thiophosphoric triamides for storage, transportation, and eventual impregnation onto solid urea containing fertilizers and incorporation into liquid urea containing fertilizer compositions. These formulations are comprised primarily of a solvent selected from the group consisting of glycols and glycol derivatives. Optionally, in addition to the glycol base solvent, the formulations can contain a co-solvent selected from the group consisting of liquid amides, 2-pyrrolidone and N-alkyl 2-pyrrolidones, and/or a nonionic surfactant selected from the group consisting of alkylaryl polyether alcohols. The presence of the co-solvent and/or surfactant has been found to impart desirable properties to the formulations under certain conditions. N-alkyl thiophosphoric triamides have been known for some time to be effective inhibitors of the activity of urease enzymes, however, commercial use has been inhibited by the lack of an acceptable carrier. They are often thermally and hydrolytically unstable and difficult to handle. The use of the solvent systems offers many advantages including: (1) improved stability of the active ingredient urease inhibitor; (2) excellent solubility characteristics; (3) extremely low flammability and toxicity of the solvents; (4) excellent cold temperature storage and handling characteristics with the addition of the liquid amide co-solvent; and (5) good adsorption characteristics onto solid urea containing fertilizers and excellent miscibility with liquid urea containing fertilizer formulations.
摘要翻译： 改进的用于制备N-烷基硫代磷酸三酰胺脲酶抑制剂的溶剂体系。 这些制剂使得能够制备N-烷基硫代磷酸三酰胺的稳定浓缩溶液，用于储存，运输和最终浸渍到固体含尿素肥料上并掺入含有液体尿素的肥料组合物中。 这些制剂主要由选自二醇和二醇衍生物的溶剂组成。 任选地，除了二醇基溶剂之外，制剂可以含有选自液体酰胺，2-吡咯烷酮和N-烷基2-吡咯烷酮的共溶剂，和/或选自以下的非离子表面活性剂： 烷基芳基聚醚醇。 发现共溶剂和/或表面活性剂的存在在某些条件下赋予制剂所需的性质。 N-烷基硫代磷酸三酰胺已知已有一段时间是有效的尿素酶活性抑制剂，然而商业用途已被缺乏可接受的载体所抑制。 它们通常是热和水解不稳定的并且难以处理。 使用溶剂系统具有许多优点，包括：（1）提高活性成分脲酶抑制剂的稳定性; （2）优异的溶解度特性; （3）溶剂的易燃性和毒性极低; （4）通过加入液体酰胺共溶剂，具有优异的低温储存和处理特性; 和（5）对固体含尿素肥料的吸附性能优异，与含有液体尿素的肥料配方具有优异的混溶性。
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2.发明授权Method of preparing mixtures of active ingredients and excipients using liquid carbon dioxide 失效使用液体二氧化碳制备活性成分和成分的混合物的方法
公开(公告)号：US5169433A
公开(公告)日：1992-12-08
申请号：US553630
申请日：1990-07-18
CPC分类号： B01F3/22 , B01F1/0005 , B01F3/2246
摘要： Environmentally-acceptable intimate mixtures of active ingredients and excipients which meet economic performance levels are prepared without use of harmful solvents by solubilizing and mixing the components in liquid carbon dioxide maintained under pressure and then slowly reducing the pressure to convert the carbon dioxide to the gaseous phase and venting the gaseous carbon dioxide.
摘要翻译： 通过在保持在压力下的液态二氧化碳中溶解和混合组分，然后缓慢降低压力以将二氧化碳转化为气相，通过在不使用有害溶剂的情况下制备满足经济性能水平的活性成分和赋形剂的环境可接受的密实混合物 并排出气态二氧化碳。
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公开(公告)号：US5504014A
公开(公告)日：1996-04-02
申请号：US90632
申请日：1993-07-12
CPC分类号： G01N33/5308 , Y10T436/13
摘要： The cleanliness of water-rinsed surfaces originally carrying hazardous compositions is determined by using a surface active agent as a marker in said material prior to placing the composition into contact with the surface.
摘要翻译： 最初携带危险组合物的水冲洗表面的清洁度是在将组合物与表面接触之前，通过使用表面活性剂作为所述材料中的标记来确定的。
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公开(公告)号：US5843203A
公开(公告)日：1998-12-01
申请号：US620937
申请日：1996-03-22
CPC分类号： A01N25/12 , A01M1/20 , Y10S71/904
摘要： An improved agricultural carrier and a method of making the carrier is disclosed. The granular carrier is adapted for carrying a low-melting chemical, specifically pesticides. An aromatic solvent is used to dissolve the low-melting chemical, before combining it with the carrier. The granular carrier unexpectedly exceeds its liquid holding capacity for the low-melting chemical.
摘要翻译： 公开了一种改进的农业载体和制造载体的方法。 粒状载体适用于携带低熔点化学品，特别是农药。 在将其与载体组合之前，使用芳族溶剂来溶解低熔点化学品。 颗粒载体意外超过其低熔点化学品的液体保持能力。
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5.发明授权Formulations and methods for administration of pharmacologically or biologically active compounds 失效用于施用药理学或生物活性化合物的制剂和方法公开(公告)号：US06780885B1
公开(公告)日：2004-08-24
申请号：US09483084
申请日：2000-01-14
IPC分类号： A61K3140
CPC分类号： A61K31/7048 , A01N25/02 , A01N43/90 , A61K9/0017 , A61K31/35 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/498 , A61K31/505 , A61K31/506 , A61K31/65 , A61K31/7056 , A61K47/10 , A61K47/22 , A61K47/26 , A01N25/30 , A01N25/04 , A01N2300/00
摘要： The present invention provides non-aqueous compositions which comprise a pharmacologically or biologically active compound, an emulsifier, a polyol, and benzyl alcohol. The compositions are useful for administering the pharmacologically or biologically active compounds which they contain to animals, plants, or ground surfaces. In preferred embodiments, the pharmacologically or biologically active compounds may be water-insoluble or water-labile. The compositions of the present invention allow these compounds to be solubilized and conveniently transported to a site of application in a non-aqueous form, and then diluted in an aqueous solution. In a particularly preferred embodiment, the compound is ivermectin and is administered in the drinking water of poultry. The compositions of the present invention may also contain multiple pharmacologically or biologically active compounds which are administered simultaneously. The present invention also provides methods of administering the compounds. In the most preferred embodiment, the compounds may be administered in the drinking water of animals to be treated with the pharmacologically or biologically active compound. In other embodiments, the compositions may be topically applied to the animals or plants to be treated, or sprayed onto plants, animals, or a ground surface to be treated with the active compounds.
摘要翻译： 本发明提供了包含药理学或生物活性化合物，乳化剂，多元醇和苄醇的非水组合物。 所述组合物可用于给予动物，植物或地面所含有的药理学或生物活性化合物。 在优选的实施方案中，药理学或生物活性化合物可以是水不溶性的或水不稳定的。 本发明的组合物允许这些化合物溶解并方便地以非水形式运送到施用部位，然后在水溶液中稀释。 在特别优选的实施方案中，化合物是伊维菌素，并且在家禽的饮用水中施用。 本发明的组合物还可以含有同时施用的多种药理学或生物活性化合物。 本发明还提供了施用化合物的方法。 在最优选的实施方案中，化合物可以在待用药理学或生物活性化合物处理的动物的饮用水中施用。 在其它实施方案中，可将组合物局部施用于待处理的动物或植物，或喷洒到待用活性化合物处理的植物，动物或研磨表面上。
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6.发明授权Storage stable pesticide compositions comprising azadirachtin and epoxide 失效包含印苦楝子素和环氧化物的储存稳定的农药组合物
公开(公告)号：US5352697A
公开(公告)日：1994-10-04
申请号：US920800
申请日：1992-07-28
CPC分类号： A01N43/90 , A01N25/22 , A01N65/00 , A01N65/26 , Y10S424/08
摘要： Storage-stable pesticide compositions comprising azadirachtin or an azadirachtin derivative as the active ingredient and an epoxide as the stabilizing agent.
摘要翻译： 包含印苦楝子素或印苦楝子素衍生物作为活性成分的储存稳定的农药组合物和作为稳定剂的环氧化物。
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公开(公告)号：US4183763A
公开(公告)日：1980-01-15
申请号：US864822
申请日：1977-12-27
CPC分类号： A01N25/12 , B01J20/045 , C01F11/46 , C04B18/021 , C01P2004/50 , C01P2004/61 , C01P2006/10 , C01P2006/19 , C01P2006/82
摘要： Calcium sulfate hemihydrate is processed into agglomerates such as granules and/or macrogranules by addition of an aqueous binder to a fluidized charge of calcium sulfate hemihydrate particles. The hemihydrate particles are agglomerated to a predetermined size range and hydrated to calcium sulfate dihydrate. The produced agglomerates have a bulk density of less than about 55 pounds per cubic foot, a surface hardness providing less than about 40 percent attrition, and a liquid holding capacity of at least about 10 percent.
摘要翻译： 将硫酸钙半水合物通过将水性粘合剂加入流化床的硫酸钙半水合物颗粒中而加工成颗粒和/或大颗粒的附聚物。 将半水合物颗粒凝聚至预定尺寸范围并水化成硫酸钙二水合物。 生产的附聚物的堆积密度小于约55磅/立方英尺，表面硬度提供小于约40％的磨耗，并且液体保持能力至少为约10％。
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