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公开(公告)号：US06440096B1
公开(公告)日：2002-08-27
申请号：US09616771
申请日：2000-07-14
IPC分类号： A61N130
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150984 , A61B5/15142 , A61B17/205 , A61M2037/0023 , A61M2037/003 , A61M2037/0038
摘要： A device for monitoring, sampling or delivering a substance though the skin of a patient includes a support and a microdevice having at least one skin penetrating member. The support has a substantially flat bottom surface with the skin penetrating member extending beyond the bottom surface. An outlet port extends through the support to the bottom surface at a location between the skin penetrating member and the outer edge of the support for drawing a vacuum to enhance penetration of the skin. The device is produced by positioning the microdevice in a recess formed in the support and applying a bonding agent to wick into a gap formed between the microdevice and the wall of the recess.
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2.发明授权Device for withdrawing or administering a substance and method of manufacturing a device 有权用于取出或管理物质的装置和制造装置的方法公开(公告)号：US06607513B1
公开(公告)日：2003-08-19
申请号：US09590062
申请日：2000-06-08
IPC分类号： A61M500
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , B33Y80/00
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
摘要翻译： 一种装置包括用于通过患者皮肤递送或取出物质的多个皮肤穿透装置。 该装置具有形成有顶端和底端以及轴向延伸穿过支撑件的多个通道的支撑件。 多个皮肤穿透构件定位在通道中，其顶端从支撑件的底端延伸。 联接构件附接到支撑件以与流体供应件联接并将流体引导到皮肤穿透构件。 皮肤穿透构件具有约100微米至约2000微米的长度，并且为约30至50度。
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公开(公告)号：US20160207253A9
公开(公告)日：2016-07-21
申请号：US13442933
申请日：2012-04-10
CPC分类号： A61B5/150282 , A61M5/3298 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , A61M2207/00 , B29C65/08 , B29L2031/7544 , Y10T29/49826 , Y10T156/10
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
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4.发明授权公开(公告)号：US08172815B2
公开(公告)日：2012-05-08
申请号：US10443822
申请日：2003-05-23
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/003 , B33Y80/00
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
摘要翻译： 一种装置包括用于通过患者皮肤递送或取出物质的多个皮肤穿透装置。 该装置具有形成有顶端和底端以及轴向延伸穿过支撑件的多个通道的支撑件。 多个皮肤穿透构件定位在通道中，其顶端从支撑件的底端延伸。 联接构件附接到支撑件以与流体供应件联接并将流体引导到皮肤穿透构件。 皮肤穿透构件具有约100微米至约2000微米的长度，并且为约30至50度。
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5.发明授权公开(公告)号：US07083592B2
公开(公告)日：2006-08-01
申请号：US10951217
申请日：2004-09-27
申请人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
发明人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
IPC分类号： A61B17/20
CPC分类号： A61M5/425 , A61M5/14244 , A61M5/3007 , A61M5/46 , A61M37/0015
摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.
摘要翻译： 提供了一种用于通过至少一层皮肤递送或取出流体的装置。 一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。 底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。 底面还包括设置在第二表面区域上的至少一个凸起突起。 突起具有从第一表面的高度大于第一距离。 在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。 真皮进入构件从突起延伸至少1mm。 机构以约6m / s至约18m / s的计算速度驱动装置抵靠皮肤。
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6.发明授权公开(公告)号：US06808506B2
公开(公告)日：2004-10-26
申请号：US10357502
申请日：2003-02-04
申请人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
发明人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
IPC分类号： A61B1720
CPC分类号： A61M5/425 , A61M5/14244 , A61M5/3007 , A61M5/46 , A61M37/0015
摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.
摘要翻译： 提供了一种用于通过至少一层皮肤递送或取出流体的装置。 一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。 底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。 底面还包括设置在第二表面区域上的至少一个凸起突起。 突起具有从第一表面的高度大于第一距离。 在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。 真皮进入构件从突起延伸至少1mm。 机构以约6m / s至约18m / s的计算速度驱动装置抵靠皮肤。
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公开(公告)号：US09717451B2
公开(公告)日：2017-08-01
申请号：US13442933
申请日：2012-04-10
CPC分类号： A61B5/150282 , A61M5/3298 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , A61M2207/00 , B29C65/08 , B29L2031/7544 , Y10T29/49826 , Y10T156/10
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
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8.发明申请Device for Withdrawing or Administering a Substance and Method of Manufacturing a Device 有权取出或管理物质的装置和制造装置的方法公开(公告)号：US20130263997A1
公开(公告)日：2013-10-10
申请号：US13442933
申请日：2012-04-10
CPC分类号： A61B5/150282 , A61M5/3298 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , A61M2207/00 , B29C65/08 , B29L2031/7544 , Y10T29/49826 , Y10T156/10
摘要： A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
摘要翻译： 一种装置包括用于通过患者皮肤递送或取出物质的多个皮肤穿透装置。 该装置具有形成有顶端和底端以及轴向延伸穿过支撑件的多个通道的支撑件。 多个皮肤穿透构件定位在通道中，其顶端从支撑件的底端延伸。 联接构件附接到支撑件以与流体供应件联接并将流体引导到皮肤穿透构件。 皮肤穿透构件具有约100微米至约2000微米的长度，并且为约30至50度。
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9.发明申请Device and method for delivering or withdrawing a substance through the skin 审中-公开通过皮肤递送或取出物质的装置和方法公开(公告)号：US20100292648A1
公开(公告)日：2010-11-18
申请号：US12845373
申请日：2010-07-28
申请人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
发明人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
IPC分类号： A61M5/00
CPC分类号： A61M5/425 , A61M5/14244 , A61M5/3007 , A61M5/46 , A61M37/0015
摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.
摘要翻译： 提供了一种用于通过至少一层皮肤递送或取出流体的装置。 一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。 底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。 底面还包括设置在第二表面区域上的至少一个凸起突起。 突起具有从第一表面的高度大于第一距离。 在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。
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10.发明申请Device and method for delivering or withdrawing a substance through the skin 审中-公开通过皮肤递送或取出物质的装置和方法公开(公告)号：US20090112181A1
公开(公告)日：2009-04-30
申请号：US12341589
申请日：2008-12-22
申请人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
发明人： Alexander G. Lastovich , James K. Fentress , Julia Griggs , Ronald J. Pettis , Diane Sutter , Frank E. Martin , M. Ishaq Haider
IPC分类号： A61M5/32
CPC分类号： A61M5/425 , A61M5/14244 , A61M5/3007 , A61M5/46 , A61M37/0015
摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.
摘要翻译： 提供了一种用于通过至少一层皮肤递送或取出流体的装置。 一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。 底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。 底面还包括设置在第二表面区域上的至少一个凸起突起。 突起具有从第一表面的高度大于第一距离。 在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。
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