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公开(公告)号：US20160311877A1
公开(公告)日：2016-10-27
申请号：US15105298
申请日：2014-12-18
申请人： Alexander WATTERS , Donald INGBER , Mark CARTWRIGHT , Michael SUPER , Martin ROTTMAN , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Alexander WATTERS , Donald INGBER , Mark CARTWRIGHT , Michael SUPER , Martin ROTTMAN , Evangelina MURRAY , Brendon DUSEL
IPC分类号： C07K14/47 , A61K47/42 , G01N33/569
摘要： Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
摘要翻译： 本文描述了工程化的微生物靶向分子，微生物靶向制品，包含其的试剂盒及其用途。 这样的微生物靶向分子，微生物靶向制品或包含其的试剂盒可以结合或捕获其微生物或微生物物质，因此可以用于各种应用中，例如诊断或治疗由微生物引起的感染 主题或任何环境表面。
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公开(公告)号：US20200283506A1
公开(公告)日：2020-09-10
申请号：US16879015
申请日：2020-05-20
IPC分类号： C07K14/78 , G01N33/569 , C07K14/00 , C07K14/47 , C07K19/00
摘要： Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
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3.发明申请公开(公告)号：US20190145980A1
公开(公告)日：2019-05-16
申请号：US16092288
申请日：2017-04-10
IPC分类号： G01N33/574 , A61K39/00 , A61K47/64
摘要： The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.
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公开(公告)号：US20190389935A1
公开(公告)日：2019-12-26
申请号：US16553635
申请日：2019-08-28
IPC分类号： C07K14/78 , G01N33/569
摘要： Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
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公开(公告)号：US20180371058A1
公开(公告)日：2018-12-27
申请号：US15750788
申请日：2016-08-04
IPC分类号： C07K14/78 , G01N33/569
CPC分类号： C07K14/78 , A61K38/00 , C07K14/00 , C07K14/4726 , C07K19/00 , C07K2319/30 , G01N33/569 , G01N2333/78 , G01N2400/00
摘要： Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
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公开(公告)号：US20220281955A1
公开(公告)日：2022-09-08
申请号：US17552662
申请日：2021-12-16
IPC分类号： C07K14/78 , G01N33/569 , C07K14/00 , C07K14/47 , C07K19/00
摘要： Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e g, enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
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