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    MODIFICATION OF SURFACES FOR FLUID AND SOLID REPELLENCY
    5.
    发明申请
    MODIFICATION OF SURFACES FOR FLUID AND SOLID REPELLENCY 审中-公开
    流体和固体废物表面改性

    公开(公告)号：US20160144079A1

    公开(公告)日：2016-05-26

    申请号：US14904399

    申请日：2014-07-10

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： Donald INGBER ,  Daniel C. LESLIE ,  Michael SUPER ,  Alexander L. WATTERS ,  Anna WATERHOUSE

    IPC: A61L31/08

    CPC classification number: A61L31/08 ,  A61L27/34 ,  A61L29/08 ,  A61L29/085 ,  A61L31/14 ,  A61L2400/10 ,  A61L2420/02 ,  B05D5/08 ,  B05D5/086 ,  C09D5/16

    Abstract: Articles, methods of making, and uses for modifying surfaces for liquid repellency are disclosed. The liquid repellant surfaces comprise a surface comprising an anchoring layer. The anchoring layer, which forms an immobilized molecular anchoring layer on the surface, has anchoring molecules, where each anchoring molecule has a head group that is covalently linked to the surface and a functional tail group. The anchoring molecules are crosslinked to each other to form a crosslinked network. The functional tail group has an affinity for a lubricating liquid, which is applied to the treated surface to form a lubricating layer. The anchoring layer and replenishable lubricating liquid are held together by non-covalent attractive forces. Together, these layers form an ultra-repellant slippery surface that repels certain immiscible liquids and prevents adsorption, coagulation, and surface fouling by components contained within.

    Abstract translation: 公开了制品的制造方法和用于改性表面的疏液性的用途。 排液表面包括包含锚定层的表面。 在表面上形成固定化分子锚定层的锚定层具有锚定分子，其中每个锚定分子具有与表面共价连接的头基和功能尾组。 锚定分子彼此交联以形成交联网络。 功能尾组对润滑液具有亲和性，润滑液被施加到被处理表面以形成润滑层。 锚定层和补充润滑液通过非共价吸引力保持在一起。 一起，这些层形成一个超疏水滑表面，排斥某些不混溶的液体，并防止其中所含组分的吸附，凝结和表面结垢。

    MICROBE-BINDING MOLECULES AND USES THEREOF
    8.
    发明申请
    MICROBE-BINDING MOLECULES AND USES THEREOF 审中-公开

    公开(公告)号：US20200283506A1

    公开(公告)日：2020-09-10

    申请号：US16879015

    申请日：2020-05-20

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： Alexander WATTERS ,  Brendon Dusel ,  Michael SUPER ,  Mark CARTWRIGHT ,  Donald E. INGBER

    IPC: C07K14/78 ,  G01N33/569 ,  C07K14/00 ,  C07K14/47 ,  C07K19/00

    Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.

    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF
    9.
    发明申请
    ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF 审中-公开

    公开(公告)号：US20200239552A1

    公开(公告)日：2020-07-30

    申请号：US16683630

    申请日：2019-11-14

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： Donald E. INGBER ,  Michael SUPER ,  Jeffrey Charles WAY ,  Mark J. CARTWRIGHT ,  Julia B. BERTHET ,  Dinah R. SUPER ,  Martin ROTTMAN ,  Alexander L. WATTERS

    IPC: C07K16/12 ,  A61K47/68 ,  G01N33/543 ,  G01N33/569 ,  C07K14/42

    Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

    ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT
    10.
    发明申请
    ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT 审中-公开

    公开(公告)号：US20200095300A1

    公开(公告)日：2020-03-26

    申请号：US16702724

    申请日：2019-12-04

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： Michael SUPER ,  Jeffrey Charles WAY ,  Donald E. INGBER

    IPC: C07K14/47 ,  G01N33/569 ,  C07K16/44 ,  C07K17/00

    Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

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