公开(公告)号：US07378424B2

公开(公告)日：2008-05-27

申请号：US10786400

申请日：2004-02-24

申请人： Alexander William Oxford ,  David Jack

发明人： Alexander William Oxford ,  David Jack

IPC分类号： A61K31/513 ,  A61K31/517 ,  C07D487/14 ,  C07D239/70

CPC分类号： C07D471/04

摘要： The invention provides compounds or salts thereof of the general formula (I): wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; X represents OCH2 or a group CR3R4; wherein each of R3 or R4 independently represents a hydrogen atom or a C1-3 alkyl group; R5 represents a hydrogen atom or a C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl group; R6 represents a hydrogen atom or a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, amino, C1-6 alkylamino, di(C1-6) alkylamino or C2-7 acylamino group; each of R7 and R8 independently represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkylthio, C1-6 alkoxy, C3-6 cycloalkyl; and R9 represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkylthio, C1-6 alkoxy or C3-6 cycloalkyl group. The compounds or salts thereof are useful for treatment of respiratory disorders such as asthma. Compounds of the invention have a longer duration of action than the known compound trequinsin (9,10-dimethoxy-3 methyl-2-mesitylimino-2, 3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one).

公开(公告)号：US06794391B2

公开(公告)日：2004-09-21

申请号：US09964260

申请日：2001-09-26

申请人： Alexander William Oxford ,  David Jack

发明人： Alexander William Oxford ,  David Jack

IPC分类号： A61K31505

CPC分类号： C07D471/04

摘要： The invention provides compounds or salts thereof of the general formula (I): wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; X represents OCH2 or a group CR3R4; wherein each of R3 or R4 independently represents a hydrogen atom or a C1-3 alkyl group; R5 represents a hydrogen atom or a C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl group; R6 represents a hydrogen atom or a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, amino, C1-6 alkylamino, di(C1-6) alkylamino or C2-7 acylamino group; each of R7 and R8 independently represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkylthio, C1-6 alkoxy, C3-6 cycloalkyl; and R9 represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkylthio, C1-6 alkoxy or C3-6 cycloalkyl group. The compounds or salts thereof are useful for treatment of respiratory disorders such as asthma. Compounds of the invention have a longer duration of action than the known compound trequinsin (9,10-dimethoxy-3 methyl-2-mesitylimino-2,3,6,7-tetrahydro-4-H-pyrimido[6,1-a]isoquinolin-4-one).

摘要翻译： 本发明提供了通式（I）的化合物或其盐：其中R 1和R 2各自独立地表示C 1-6烷基或C 2-7酰基; X表示OCH 2或基团CR 3 R 4; 其中R 3或R 4各自独立地表示氢原子或C 1-3烷基; R 5表示氢原子或C 1-3烷基，C 2-3烯基或C 2-3炔基; R 6表示氢原子或C 1-6烷基，C 2-6烯基，C 2-6炔基，氨基，C 1-6烷基氨基，二（C 1-6）烷基氨基或C 2-7酰氨基; R 7和R 8中的每一个独立地表示氢或卤素原子或羟基，三氟甲基，C 1-6烷基，C 2-6烯基，C 2-6炔基，C 2-7酰基，C 1-6烷硫基，C 1 -6烷氧基，C3-6环烷基; 并且R 9表示氢或卤素原子或羟基，三氟甲基，C 1-6烷基，C 2-6烯基，C 2-6炔基，C 2-7酰基，C 1-6烷硫基，C 1-6烷氧基或C 3-6 环烷基。 其化合物或其盐可用于治疗呼吸系统疾病如哮喘。 本发明化合物的作用时间长于已知的化合物叶绿素（9,10-二甲氧基-3甲基-2-新三甲基-2,3,6,7-四氢-4H-嘧啶并[6,1-a ]异喹啉-4-酮）。

公开(公告)号：US20080206163A1

公开(公告)日：2008-08-28

申请号：US12150232

申请日：2008-04-24

申请人： Alexander William Oxford ,  David Jack

发明人： Alexander William Oxford ,  David Jack

IPC分类号： A61K9/12 ,  C07D471/04 ,  A61K31/519

CPC分类号： C07D471/04

摘要： Compounds of general formula (I) wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; R5 represents a hydrogen atom or a C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl group; R6 represents a hydrogen atom or a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, amino, C1-6 alkylamino, di(C1-6) alkylamino or C2-7 acylamino group; each of R7 and R8 independently represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkythio, C1-6 alkoxy, C3-6 cycloalkyl; and R9 represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkythio, C1-6 alkoxy or C3-6 cycloalkyl group; X represents OCH2 or a group CR3R4, wherein each of R3 and R4 independently represents a hydrogen atom or a C1-3 alkyl group; each of R10 and R11 independently represents a hydrogen atom, a C1-3 alkyl, C3-6 cycloalkyl or phenyl group; y represents an oxygen atom or a group CHNO2, NCN, NH or NNO2, n is an integer from 2 to 4; or a salt thereof; are useful for treatment of respiratory disorders such as asthma. Compounds of the invention have a longer duration of action than the known compound trequinsin (9,10-dimethoxy-3-methyl-2-mesitylimino-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one) and do not have trequinsin's very bitter taste.

公开(公告)号：US07105663B2

公开(公告)日：2006-09-12

申请号：US10786650

申请日：2004-02-24

申请人： Alexander William Oxford ,  David Jack

发明人： Alexander William Oxford ,  David Jack

IPC分类号： C07D239/00 ,  C07D487/00 ,  C07D471/00 ,  C07D498/00 ,  C07D453/00 ,  C07D455/00

CPC分类号： C07D471/04

摘要： Compounds of general formula (I) wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; R5 represents a hydrogen atom or a C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl group; R6 represents a hydrogen atom or a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, amino, C1-6 alkylamino, di(C1-6)alkylamino or C2-7 acylamino group, each of R7 and R8 independently represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkythio, C1-6 alkoxy, C3-6 cycloalkyl; and R9 represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-7 acyl, C1-6 alkythio, C1-6 alkoxy or C3-6 cycloalkyl group; X represents OCH2 or a group CR3R4, wherein each of R3 and R4 independently represents a hydrogen atom or a C1-3 alkyl group; each of R10 and R11 independently represents a hydrogen atom, a C1-3 alkyl, C3-6 cycloalkyl or phenyl group; y represents an oxygen atom or a group CHNO2, NCN, NH or NNO2, n is an integer from 2 to 4; or a salt thereof; are useful for treatment of respiratory disorders such as asthma. Compounds of the invention have a longer duration of action than the known compound trequinsin (9,10-dimethoxy-3-methyl-2-mesitylimino-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]-isoquinolin-4-one) and do not have trequinsin's very bitter taste.

公开(公告)号：US20120302533A1

公开(公告)日：2012-11-29

申请号：US13568754

申请日：2012-08-07

申请人： Alexander William Oxford ,  David Jack

发明人： Alexander William Oxford ,  David Jack

IPC分类号： A61K31/519 ,  A61P11/08 ,  A61P29/00 ,  A61K31/56

CPC分类号： C07D471/04

摘要： The present invention relates to derivatives of pyrimido[6,1-a]isoquinolin-4-one and their application as inhibitors of phosphodiesterase (PDE) isoenzymes. More particularly the invention relates to derivatives of pyrimido[6,1-a]isoquinolin-4-one and their use in medicine for example as bronchodilators with anti-inflammatory properties.

摘要翻译： 本发明涉及嘧啶并[6,1-a]异喹啉-4-酮的衍生物及其作为磷酸二酯酶（PDE）同功酶抑制剂的应用。 更具体地，本发明涉及嘧啶并[6,1-a]异喹啉-4-酮的衍生物及其在医学中的用途，例如具有抗炎性质的支气管扩张剂。

公开(公告)号：US08242127B2

公开(公告)日：2012-08-14

申请号：US12150232

申请日：2008-04-24

申请人： Alexander William Oxford ,  David Jack

发明人： Alexander William Oxford ,  David Jack

IPC分类号： A01N43/54 ,  A61K31/505

CPC分类号： C07D471/04

摘要： The present invention relates to derivatives of pyrimido[6,1-a]isoquinolin-4-one and their application as inhibitors of phosphodiesterase (PDE) isoenzymes. More particularly the invention relates to derivatives of pyrimido[6,1-a]isoquinolin-4-one and their use in medicine for example as bronchodilators with anti-inflammatory properties.

摘要翻译： 本发明涉及嘧啶并[6,1-a]异喹啉-4-酮的衍生物及其作为磷酸二酯酶（PDE）同功酶抑制剂的应用。 更具体地，本发明涉及嘧啶并[6,1-a]异喹啉-4-酮的衍生物及其在医学中的用途，例如具有抗炎性质的支气管扩张剂。

公开(公告)号：US07944862B2

公开(公告)日：2011-05-17

申请号：US11557725

申请日：2006-11-08

申请人： Nathan Taylor ,  David Jack ,  Mario Sammut ,  Marwan A. Jabri ,  Brody Kenrick

发明人： Nathan Taylor ,  David Jack ,  Mario Sammut ,  Marwan A. Jabri ,  Brody Kenrick

IPC分类号： H04L12/16

CPC分类号： H04L29/06027 ,  H04L65/1009 ,  H04L65/103 ,  H04L65/104 ,  H04L65/1069

摘要： In one aspect, a method of establishing a reduced setup time session through a gateway is provided which includes: receiving a first capability message transmitted from the first terminal to the gateway; receiving a second capability message transmitted from the second terminal to the gateway; transmitting first and second capability response messages from the terminal to the first and second terminals, respectively; receiving a media stream transmitted from the second terminal to the gateway; processing the media stream, including identifying a temporal feature in the media stream that enables a decoder to establish a decoder refresh point; receiving an acknowledgment message transmitted from the first terminal to the gateway; and, thereafter transmitting the processed media from the gateway to the first terminal.

摘要翻译： 一方面，提供了一种通过网关建立简化建立时间会话的方法，包括：接收从第一终端发送到网关的第一能力消息; 接收从所述第二终端发送到所述网关的第二能力消息; 从终端分别向第一和第二终端发送第一和第二能力响应消息; 接收从所述第二终端发送到所述网关的媒体流; 处理媒体流，包括识别媒体流中的时间特征，使得解码器能够建立解码器刷新点; 接收从所述第一终端发送到所述网关的确认消息; 然后将处理过的媒体从网关发送到第一终端。

公开(公告)号：US20100268836A1

公开(公告)日：2010-10-21

申请号：US12661468

申请日：2010-03-16

申请人： Marwan Jabri ,  David Jack ,  Wei Zhou ,  Brody Kenrick ,  Kshitij Gupta

发明人： Marwan Jabri ,  David Jack ,  Wei Zhou ,  Brody Kenrick ,  Kshitij Gupta

IPC分类号： G06F15/16

CPC分类号： H04L47/38 ,  H04L65/605 ,  H04W28/06

摘要： A method of transmitting media to a client by an infrastructure device in a packet-switched network includes receiving a media stream at the infrastructure device. The method also includes determining an adaptation strategy according to at least one of one or more pieces of network information associated with the packet-switched network, one or more pieces of client information associated with the client, or one or more policies. The method further includes adapting the media stream according to the adaptation strategy to produce an output media stream.

摘要翻译： 通过分组交换网络中的基础设施设备向客户端发送媒体的方法包括在基础设施设备处接收媒体流。 该方法还包括根据与分组交换网络相关联的一个或多个网络信息，与客户端相关联的一个或多个客户信息或一个或多个策略来确定适配策略。 该方法还包括根据自适应策略来适配媒体流以产生输出媒体流。

公开(公告)号：US20080059647A1

公开(公告)日：2008-03-06

申请号：US11825309

申请日：2007-07-03

申请人： Marwan Jabri ,  David Jack ,  David Myers

发明人： Marwan Jabri ,  David Jack ,  David Myers

IPC分类号： G06F15/173

CPC分类号： H04N21/64707 ,  H04L29/06 ,  H04L29/06027 ,  H04L29/12009 ,  H04L61/00 ,  H04L65/605 ,  H04L65/607 ,  H04L67/2823 ,  H04L69/329

摘要： A system (and methods) for transferring multimedia information from a source location to a destination location through one or more networks, which may be different. The system has a source output which provides a first stream of information in a first format. The system also has a destination input which receives a second stream of information in a second format. A proxy transcoder server (“PTS”) is coupled between the source output and the destination input. The PTS has a transcoding module transcoding data. The PTS also has a capability module identifying a first capability of the source output and a second capability of the destination input, and selecting a transcoding process based upon the first capability and the second capability.

摘要翻译： 一种用于通过可能不同的一个或多个网络将多媒体信息从源位置传送到目的地位置的系统（和方法）。 该系统具有以第一格式提供第一信息流的源输出。 系统还具有以第二格式接收第二信息流的目的地输入。 代理代码转换器服务器（“PTS”）耦合在源输出和目标输入之间。 PTS具有代码转换模块代码转换数据。 PTS还具有识别源输出的第一能力和目的地输入的第二能力的能力模块，以及基于第一能力和第二能力选择代码转换过程。

公开(公告)号：US20070266161A1

公开(公告)日：2007-11-15

申请号：US11548670

申请日：2006-10-11

申请人： Brody Kenrick ,  Marwan Jabri ,  Robert Jongbloed ,  David Jack ,  Albert Wong

发明人： Brody Kenrick ,  Marwan Jabri ,  Robert Jongbloed ,  David Jack ,  Albert Wong

IPC分类号： G06F15/16

CPC分类号： H04L65/1069 ,  H04L65/1009 ,  H04M7/0072

摘要： A method of reducing a call set-up time between a pair of H.324-like terminals coupled to one or more telecommunication networks includes providing a first capability identifier in at least one of a non-standard or generic field of a first TCS message, transmitting the first capability identifier from the first H.324-like terminal to the second H.324-like terminal, and receiving, at the first H.324-like terminal, a second capability identifier in at least one of a non-standard or generic field of a second TCS message transmitted from the second H.324-like terminal. The method also includes determining, at the first H.324-like terminal, a mode of operation by utilizing an inference algorithm based upon at least the first capability identifier and the second capability identifier. The method further includes transmitting media from the first H.324-like terminal to the second H.324-like terminal in accordance with the determined mode of operation.

摘要翻译： 一种减少耦合到一个或多个电信网络的一对H.324类终端之间的呼叫建立时间的方法包括：在第一TCS消息的非标准或通用字段中的至少一个中提供第一能力标识符 将第一能力标识符从第一H.324类终端发送到第二H.324类终端，并且在第一H.324类终端处接收第一能力标识符中的至少一个， 从第二H.324类终端发送的第二TCS消息的标准或通用字段。 该方法还包括基于至少第一能力标识符和第二能力标识符，利用推理算法在第一H.324类终端处确定操作模式。 该方法还包括根据确定的操作模式将介质从第一H.324类终端发送到第二H.324类终端。