公开(公告)号：US08097594B2

公开(公告)日：2012-01-17

申请号：US12379539

申请日：2009-02-24

申请人： Milind Dattatraya Sindkhedkar ,  Vijaya Narayan Desai ,  Rajesh Maganlal Loriya ,  Mahesh Vithalbhai Patel ,  Bharat Kalidas Trivedi ,  Rajesh Onkardas Bora ,  Santosh Devidas Diwakar ,  Ganesh Rajaram Jadhav ,  Shivaji Sampatrao Pawar

发明人： Milind Dattatraya Sindkhedkar ,  Vijaya Narayan Desai ,  Rajesh Maganlal Loriya ,  Mahesh Vithalbhai Patel ,  Bharat Kalidas Trivedi ,  Rajesh Onkardas Bora ,  Santosh Devidas Diwakar ,  Ganesh Rajaram Jadhav ,  Shivaji Sampatrao Pawar

IPC分类号： A61K31/70 ,  C07H17/08

CPC分类号： C07D493/04

摘要： The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel semi-synthetic 11,12-γ lactone macrolides and ketolides having antimicrobial activity, processes for making compounds as well as pharmaceutical compositions containing said compounds as active ingredients and methods of treating microbial infections with the compounds.

摘要翻译： 本发明提供具有抗微生物活性的化合物，其用于预防和治疗由微生物感染引起的疾病。 因此，本发明涉及具有抗微生物活性的新型半合成11,12-γ内酯大环内酯和酮内酯，以及制备化合物的方法以及含有所述化合物作为活性成分的药物组合物以及用该化合物治疗微生物感染的方法。

公开(公告)号：US20130245000A1

公开(公告)日：2013-09-19

申请号：US13989611

申请日：2011-11-24

申请人： Rajesh Thotapally ,  Onkar Gangaram Kachi ,  Atish Harishchandra Rodge ,  Ashok Bhau Pathak ,  Bhavana Shrirang Kardile ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

发明人： Rajesh Thotapally ,  Onkar Gangaram Kachi ,  Atish Harishchandra Rodge ,  Ashok Bhau Pathak ,  Bhavana Shrirang Kardile ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D471/04 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/155 ,  A61K31/454 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D401/12

CPC分类号： C07D471/04 ,  A61K31/155 ,  A61K31/437 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D491/08

摘要： The present invention relates to compounds of Formula (I) that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of GPR119 receptor activity. The invention also relates to the process for preparation of the compounds, pharmaceutical compositions thereof. The invention further relates to methods of treating, preventing and/or managing diseases, disorders syndromes or conditions associated with the modulation of GPR119 receptor by using either alone or in combinations of Formula (I).

摘要翻译： 本发明涉及可用于治疗，预防和/或控制与调节GPR119受体活性相关的疾病，病症，综合征或病症的式（I）化合物。 本发明还涉及制备化合物的方法及其药物组合物。 本发明还涉及通过单独使用或以式（I）的组合来治疗，预防和/或治疗与调节GPR119受体相关的疾病，病症综合征或病症的方法。

公开(公告)号：US08729269B2

公开(公告)日：2014-05-20

申请号：US12705258

申请日：2010-02-12

申请人： Prasad Keshav Deshpande ,  Milind Dattatraya Sindkhedkar ,  Mahesh Shriram Phansalkar ,  Ravindra Dattatraya Yeole ,  Shrikant Vinayak Gupte ,  Yati Chugh ,  Nitin Shetty ,  Sachin Subhash Bhagwat ,  Milind Chintaman Shukla ,  Noel John De Souza ,  Mahesh Vithalbhai Patel

发明人： Prasad Keshav Deshpande ,  Milind Dattatraya Sindkhedkar ,  Mahesh Shriram Phansalkar ,  Ravindra Dattatraya Yeole ,  Shrikant Vinayak Gupte ,  Yati Chugh ,  Nitin Shetty ,  Sachin Subhash Bhagwat ,  Milind Chintaman Shukla ,  Noel John De Souza ,  Mahesh Vithalbhai Patel

IPC分类号： C07D411/06 ,  A61K31/454

CPC分类号： C07D491/10 ,  C07D413/10 ,  C07D413/14 ,  C07D495/10 ,  C07D497/10 ,  C07D513/10

摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

摘要翻译： 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。

公开(公告)号：US07687627B2

公开(公告)日：2010-03-30

申请号：US10935708

申请日：2004-09-07

申请人： Prasad Keshav Deshpande ,  Milind Dattatraya Sindkhedkar ,  Mahesh Shriram Phansalkar ,  Ravindra Dattatraya Yeole ,  Shrikant Vinayak Gupte ,  Yati Chugh ,  Nitin Shetty ,  Sachin Subhash Bhagwat ,  Milind Chintaman Shukla ,  Noel John De Souza ,  Mahesh Vithalbhai Patel

发明人： Prasad Keshav Deshpande ,  Milind Dattatraya Sindkhedkar ,  Mahesh Shriram Phansalkar ,  Ravindra Dattatraya Yeole ,  Shrikant Vinayak Gupte ,  Yati Chugh ,  Nitin Shetty ,  Sachin Subhash Bhagwat ,  Milind Chintaman Shukla ,  Noel John De Souza ,  Mahesh Vithalbhai Patel

IPC分类号： C07D491/113 ,  A61K31/438

CPC分类号： C07D491/10 ,  C07D413/10 ,  C07D413/14 ,  C07D495/10 ,  C07D497/10 ,  C07D513/10

摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

摘要翻译： 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。

公开(公告)号：US09000175B2

公开(公告)日：2015-04-07

申请号：US13989611

申请日：2011-11-24

申请人： Rajesh Thotapally ,  Onkar Gangaram Kachi ,  Atish Harishchandra Rodge ,  Ashok Bhau Pathak ,  Bhavana Shrirang Kardile ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

发明人： Rajesh Thotapally ,  Onkar Gangaram Kachi ,  Atish Harishchandra Rodge ,  Ashok Bhau Pathak ,  Bhavana Shrirang Kardile ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D471/04 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/454 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/155 ,  C07D413/14 ,  C07D417/14 ,  C07D491/08 ,  A61K45/06

CPC分类号： C07D471/04 ,  A61K31/155 ,  A61K31/437 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D491/08

摘要： The present invention relates to compounds of Formula (I) that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of GPR119 receptor activity. The invention also relates to the process for preparation of the compounds, pharmaceutical compositions thereof. The invention further relates to methods of treating, preventing and/or managing diseases, disorders syndromes or conditions associated with the modulation of GPR119 receptor by using either alone or in combinations of Formula (I).

摘要翻译： 本发明涉及可用于治疗，预防和/或控制与调节GPR119受体活性相关的疾病，病症，综合征或病症的式（I）化合物。 本发明还涉及制备化合物的方法及其药物组合物。 本发明还涉及通过单独使用或以式（I）的组合来治疗，预防和/或治疗与调节GPR119受体相关的疾病，病症综合征或病症的方法。

公开(公告)号：US08217058B2

公开(公告)日：2012-07-10

申请号：US12225744

申请日：2007-05-08

申请人： Mahesh Vithalbhai Patel ,  Mahesh Phansalkar ,  Vijaykumar Jagdishwar Patil ,  Milind Dattatraya Sindkhedkar ,  Prasad Keshav Deshpande

发明人： Mahesh Vithalbhai Patel ,  Mahesh Phansalkar ,  Vijaykumar Jagdishwar Patil ,  Milind Dattatraya Sindkhedkar ,  Prasad Keshav Deshpande

IPC分类号： A61K31/445 ,  C07D413/10

CPC分类号： C07D413/10 ,  A23K20/137

摘要： The present invention relates to certain substituted piperidino phenyloxazolidinones. Specifically, the invention relates to geminally disubstituted piperidino phenyloxazolidinones having antimicrobial activity with improved pharmacokinetic profile. The invention also relates to processes for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating or preventing microbial infections using the compounds of the present invention.

摘要翻译： 本发明涉及某些取代的哌啶子基苯基恶唑烷酮。 具体地，本发明涉及具有改善的药代动力学特征的具有抗微生物活性的双重取代的哌啶子基苯基恶唑烷酮。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物以及使用本发明化合物治疗或预防微生物感染的方法。

公开(公告)号：US20100144735A1

公开(公告)日：2010-06-10

申请号：US12705258

申请日：2010-02-12

申请人： Prasad Keshav Deshpande ,  Milind Dattatraya Sindkhedkar ,  Mahesh Shriram Phansalkar ,  Ravindra Dattatraya Yeole ,  Shrikant Vinayak Gupte ,  Yati Chugil ,  Nitin Shetty ,  Sachin Subhash Bhagwat ,  Milind Chintaman Shukla ,  Noel John De Souza ,  Mahesh Vithalbhai Patel

发明人： Prasad Keshav Deshpande ,  Milind Dattatraya Sindkhedkar ,  Mahesh Shriram Phansalkar ,  Ravindra Dattatraya Yeole ,  Shrikant Vinayak Gupte ,  Yati Chugil ,  Nitin Shetty ,  Sachin Subhash Bhagwat ,  Milind Chintaman Shukla ,  Noel John De Souza ,  Mahesh Vithalbhai Patel

IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/438 ,  A61K31/4545 ,  A61K31/454 ,  C07D498/10 ,  C07D495/10 ,  C07D491/113 ,  C07D413/10 ,  A61P31/04 ,  C07D491/107 ,  C07D413/14 ,  C07D513/10

CPC分类号： C07D491/10 ,  C07D413/10 ,  C07D413/14 ,  C07D495/10 ,  C07D497/10 ,  C07D513/10

摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

摘要翻译： 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。 因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。

公开(公告)号：US20100056581A1

公开(公告)日：2010-03-04

申请号：US12225744

申请日：2007-05-08

申请人： Mahesh Vithalbhai Patel ,  Mahesh Phansalkar ,  Vijaykumar Jagdishwar Patil ,  Milind Dattatraya Sindkhedkar ,  Prasad Keshav Deshpande

发明人： Mahesh Vithalbhai Patel ,  Mahesh Phansalkar ,  Vijaykumar Jagdishwar Patil ,  Milind Dattatraya Sindkhedkar ,  Prasad Keshav Deshpande

IPC分类号： A61K31/437 ,  C07D413/10 ,  A61P31/00 ,  A61P31/04

CPC分类号： C07D413/10 ,  A23K20/137

摘要： The present invention relates to certain substituted piperidino phenyloxazolidinones. Specifically, the invention relates to geminally disubstituted piperidino phenyloxazolidinones having antimicrobial activity with improved pharmacokinetic profile. The invention also relates to processes for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods for treating or preventing microbial infections using the compounds of the present invention.

摘要翻译： 本发明涉及某些取代的哌啶子基苯基恶唑烷酮。 具体地，本发明涉及具有改善的药代动力学特征的具有抗微生物活性的双重取代的哌啶子基苯基恶唑烷酮。 本发明还涉及制备本发明化合物的方法，含有本发明化合物的药物组合物以及使用本发明化合物治疗或预防微生物感染的方法。

公开(公告)号：US20090247478A1

公开(公告)日：2009-10-01

申请号：US12379539

申请日：2009-02-24

申请人： Milind Dattatraya Sindkhedkar ,  Vijaya Narayan Desai ,  Rajesh Maganlal Loriya ,  Mahesh Vithalbhai Patel ,  Bharat Kalidas Trivedi ,  Rajesh Onkardas Bora ,  Santosh Devidas Diwakar ,  Ganesh Rajaram Jadhav ,  Shivaji Sampatrao Pawar

发明人： Milind Dattatraya Sindkhedkar ,  Vijaya Narayan Desai ,  Rajesh Maganlal Loriya ,  Mahesh Vithalbhai Patel ,  Bharat Kalidas Trivedi ,  Rajesh Onkardas Bora ,  Santosh Devidas Diwakar ,  Ganesh Rajaram Jadhav ,  Shivaji Sampatrao Pawar

IPC分类号： A61K31/7048 ,  C07H17/08

CPC分类号： C07D493/04

摘要： The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel semi-synthetic 11,12-γ lactone macrolides and ketolides having antimicrobial activity, processes for making compounds as well as pharmaceutical compositions containing said compounds as active ingredients and methods of treating microbial infections with the compounds.

摘要翻译： 本发明提供具有抗微生物活性的化合物，其用于预防和治疗由微生物感染引起的疾病。 因此，本发明涉及具有抗微生物活性的新型半合成的11,12-γ-内酯大环内酯和酮内酯，以及制备化合物的方法以及含有所述化合物作为活性成分的药物组合物以及用该化合物治疗微生物感染的方法。