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公开(公告)号：US20100249860A1
公开(公告)日：2010-09-30
申请号：US12720246
申请日：2010-03-09
申请人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
发明人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
CPC分类号： A61N1/3625 , A61N1/3627 , A61N1/37247 , A61N1/3925 , A61N1/3968 , A61N1/3993
摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.
摘要翻译： 外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。 将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。 经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。
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公开(公告)号：US08340761B2
公开(公告)日：2012-12-25
申请号：US12793206
申请日：2010-06-03
申请人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
发明人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
CPC分类号： A61N1/368 , A61B17/3207 , A61B2017/00557 , A61B2017/00893 , A61N1/056 , A61N1/36578 , A61N2001/0585
摘要： Methods and devices for treating a blockage in the coronary arterial system are provided. Some blockages in the coronary arterial system restrict the blood flow to a portion of the heart, causing ischemia or infarction. Such blockages may be treated by displacing, removing and/or breaking up the blockage, which allows blood to reperfuse into the infarcted portion of the heart. Before, during, and/or after the reperfusion, cardioprotective pacing is provided to the heart. The devices have multiple electrodes in order to provide multiple locations at which the cardioprotective pacing may be delivered. The devices are adapted to deliver cardioprotective pacing to the heart via the electrode that results in a relatively high level of dyssynchrony of the heart.
摘要翻译： 提供了治疗冠状动脉系统阻塞的方法和装置。 冠状动脉系统中的一些阻塞物将血流限制到心脏的一部分，导致局部缺血或梗死。 可以通过移位，去除和/或破坏堵塞来治疗这种阻塞，其允许血液再灌注到心脏的梗塞部分。 在再灌注之前，期间和/或之后，向心脏提供心脏保护起搏。 这些装置具有多个电极，以便提供可以输送心脏保护起搏的多个位置。 该装置适于通过电极向心脏输送心脏保护性起搏，导致心脏相对较高水平的不同步。
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3.发明申请MYOCARDIAL INFARCTION TREATMENT SYSTEM WITH ELECTRONIC REPOSITIONING 有权具有电子记录功能的MYOCARDIAL INFARCTION治疗系统公开(公告)号：US20110040344A1
公开(公告)日：2011-02-17
申请号：US12793206
申请日：2010-06-03
申请人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
发明人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
CPC分类号： A61N1/368 , A61B17/3207 , A61B2017/00557 , A61B2017/00893 , A61N1/056 , A61N1/36578 , A61N2001/0585
摘要： Methods and devices for treating a blockage in the coronary arterial system are provided. Some blockages in the coronary arterial system restrict the blood flow to a portion of the heart, causing ischemia or infarction. Such blockages may be treated by displacing, removing and/or breaking up the blockage, which allows blood to reperfuse into the infarcted portion of the heart. Before, during, and/or after the reperfusion, cardioprotective pacing is provided to the heart. The devices have multiple electrodes in order to provide multiple locations at which the cardioprotective pacing may be delivered. The devices are adapted to deliver cardioprotective pacing to the heart via the electrode that results in a relatively high level of dyssynchrony of the heart.
摘要翻译： 提供了治疗冠状动脉系统阻塞的方法和装置。 冠状动脉系统中的一些阻塞物将血流限制到心脏的一部分，导致局部缺血或梗死。 可以通过移位，去除和/或破坏堵塞来治疗这种阻塞，其允许血液再灌注到心脏的梗死部分。 在再灌注之前，期间和/或之后，向心脏提供心脏保护起搏。 这些装置具有多个电极，以便提供可以输送心脏保护起搏的多个位置。 该装置适于通过电极向心脏输送心脏保护性起搏，导致心脏相对较高水平的不同步。
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公开(公告)号：US08170661B2
公开(公告)日：2012-05-01
申请号：US12496408
申请日：2009-07-01
IPC分类号： A61N1/00
CPC分类号： A61N1/362 , A61M25/10 , A61M25/10181 , A61M25/10185 , A61M25/1025 , A61M2025/105 , A61N1/056 , A61N1/375 , A61N2001/0585
摘要： Systems and methods for temporarily pacing a patient's heart are provided. One system includes a vascular treatment system having a vascular access system and a therapy system. The therapy system includes an indeflator and an elongate medical device and the elongate medical device has an inflatable member and an electrode. The indeflator is adapted to provide pressurized fluid to the inflatable member and electrical signals to the electrode, with its operation manually or automatically controlled. Devices for electrically and fluidly coupling the indeflator and the elongate medical device are also provided.
摘要翻译： 提供了临时起搏患者心脏的系统和方法。 一个系统包括具有血管通路系统和治疗系统的血管治疗系统。 该治疗系统包括一个独立器和一个细长的医疗装置，细长的医疗装置具有一个可充气构件和一个电极。 适应器适于将加压流体提供给可膨胀构件，并且电信号到电极，其操作手动或自动控制。 还提供了用于电气和流体耦合不平衡装置和细长医疗装置的装置。
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公开(公告)号：US20100004706A1
公开(公告)日：2010-01-07
申请号：US12496408
申请日：2009-07-01
CPC分类号： A61N1/362 , A61M25/10 , A61M25/10181 , A61M25/10185 , A61M25/1025 , A61M2025/105 , A61N1/056 , A61N1/375 , A61N2001/0585
摘要： Systems and methods for temporarily pacing a patient's heart are provided. One system includes a vascular treatment system having a vascular access system and a therapy system. The therapy system includes an indeflator and an elongate medical device and the elongate medical device has an inflatable member and an electrode. The indeflator is adapted to provide pressurized fluid to the inflatable member and electrical signals to the electrode, with its operation manually or automatically controlled. Devices for electrically and fluidly coupling the indeflator and the elongate medical device are also provided.
摘要翻译： 提供了临时起搏患者心脏的系统和方法。 一个系统包括具有血管通路系统和治疗系统的血管治疗系统。 该治疗系统包括一个独立器和一个细长的医疗装置，细长的医疗装置具有一个可充气构件和一个电极。 适应器适于将加压流体提供给可膨胀构件，并且电信号到电极，其操作手动或自动控制。 还提供了用于电气和流体耦合不平衡装置和细长医疗装置的装置。
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公开(公告)号：US20100056858A1
公开(公告)日：2010-03-04
申请号：US12547316
申请日：2009-08-25
申请人： Eric A. Mokelke , Allan C. Shuros
发明人： Eric A. Mokelke , Allan C. Shuros
CPC分类号： A61B17/0218 , A61B17/3207 , A61B2017/0243 , A61B2017/22001 , A61B2017/308 , A61B2090/3784 , A61N1/056 , A61N1/08 , A61N1/3625 , G16H40/63
摘要： Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with cardiac catheterization or surgery. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more devices used in the cardiac catheterization or surgery. The pacemaker controls the delivery of the pacing pulses by executing a cardioprotective pacing protocol. In one embodiment, the one or more pacing electrodes are incorporated onto an intravascular ultrasound (IVUS) catheter. In another embodiment, the one or more pacing electrodes are incorporated onto one or more cardiac surgical instruments such as a heart stabilizer and a sternal retractor.
摘要翻译： 应用心脏保护起搏来预防和/或减少与心脏导管插入术或手术相关的心脏损伤。 起搏脉冲从起搏器产生并通过一个或多个起搏电极输送，该起搏电极并入到用于心脏导管插入术或手术中的一个或多个装置上。 起搏器通过执行心脏保护起搏协议来控制起搏脉冲的输送。 在一个实施例中，将一个或多个起搏电极并入到血管内超声（IVUS）导管中。 在另一个实施例中，将一个或多个起搏电极并入一个或多个心脏外科器械，例如心脏稳定器和胸骨牵开器。
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公开(公告)号：US20090299420A1
公开(公告)日：2009-12-03
申请号：US12474448
申请日：2009-05-29
CPC分类号： A61N1/06 , A61B18/02 , A61B2017/22002 , A61B2018/0022 , A61B2018/0212 , A61B2018/0243 , A61F2/958 , A61N1/362
摘要： A method and apparatus are described for delivering myocardial pacing and cryotherapy in conjunction with a coronary revascularization procedure using one catheter/stent system. In one embodiment, a balloon-stent delivery platform incorporates pacing electrode(s) on or near the distal tip for myocardial pacing.
摘要翻译： 描述了一种用于使用一个导管/支架系统与冠状动脉血运重建术一起递送心肌起搏和冷冻治疗的方法和装置。 在一个实施例中，球囊支架递送平台包括用于心肌起搏的远侧末端上或附近的起搏电极。
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公开(公告)号：US08412326B2
公开(公告)日：2013-04-02
申请号：US12709867
申请日：2010-02-22
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译： 起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。 监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。 在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。 在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。 在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。
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公开(公告)号：US20110106197A1
公开(公告)日：2011-05-05
申请号：US12709867
申请日：2010-02-22
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译： 起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。 监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。 在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。 在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。 在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。
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公开(公告)号：US08219192B2
公开(公告)日：2012-07-10
申请号：US12496504
申请日：2009-07-01
申请人： Allan C. Shuros , Eric A. Mokelke
发明人： Allan C. Shuros , Eric A. Mokelke
IPC分类号： A61N1/00
CPC分类号： A61N1/36014 , A61N1/046 , A61N1/3625 , A61N1/39
摘要： A transcutaneous cardiac stimulation system delivers pacing pulses according to a cardioprotective pacing protocol. The pacing pulses are delivered through body-surface electrodes attached onto a patient. The cardioprotective pacing protocol specifies pacing parameters selected to augment cardiac stress on the patient's myocardium to a level effecting cardioprotection against ischemic and reperfusion injuries.
摘要翻译： 经皮心脏刺激系统根据心脏保护起搏方案提供起搏脉冲。 起搏脉冲通过附着在患者身上的体表电极传递。 心脏保护起搏方案规定了选择的起搏参数，以增加患者心肌的心脏应激，达到对缺血再灌注损伤的心脏保护作用。
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