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    Preparation of atorvastatin
    3.
    发明授权
    Preparation of atorvastatin 失效
    阿托伐他汀的制备

    公开(公告)号：US07193090B2

    公开(公告)日：2007-03-20

    申请号：US10800741

    申请日：2004-03-16

    申请人： Bhaskar Reddy Guntoori ,  Daqing Che ,  Fan Wang ,  Yajun Zhao ,  K. S. Keshava Murthy ,  Stephen E. Horne

    发明人： Bhaskar Reddy Guntoori ,  Daqing Che ,  Fan Wang ,  Yajun Zhao ,  K. S. Keshava Murthy ,  Stephen E. Horne

    IPC分类号： C07D207/00

    CPC分类号： C07D207/416 ,  C07D207/34

    摘要： A process for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester comprising: (a) reduction of 5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-oxo-1-pentanoic acid, (R)-2-hydroxy-1,2,2-triphenylethyl ester; (b) hydrolysis of (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (R)-2-hydroxy-1,2,2-triphenylethyl ester using an alkali base in a solvent to form the acid; (c) alkylation of the acid forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester.

    摘要翻译： 制备（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -5 - 羟基-3-氧代-1-庚酸叔丁酯包括：（a）还原5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基 ）羰基] -1H-吡咯-1-基] -3-氧代-1-戊酸，（R）-2-羟基-1,2,2-三苯乙基酯; （b）（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] 3-羟基-1-戊酸，（R）-2-羟基-1,2,2-三苯基乙基酯，使用碱在溶剂中形成酸; （c）酸形成（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基 吡啶-3-基] -5-羟基-3-氧代-1-庚酸叔丁酯。

    METHOD AND APPARATUS FOR NOTIFICATION OF EMITTED ENERGY
    7.
    发明申请
    METHOD AND APPARATUS FOR NOTIFICATION OF EMITTED ENERGY 有权
    用于通知发射能量的方法和装置

    公开(公告)号：US20120224559A1

    公开(公告)日：2012-09-06

    申请号：US13469512

    申请日：2012-05-11

    申请人： Xiaotao Ren ,  Lei Wan ,  Zhiyu Yan ,  Yajun Zhao ,  Xiaoan Fan

    发明人： Xiaotao Ren ,  Lei Wan ,  Zhiyu Yan ,  Yajun Zhao ,  Xiaoan Fan

    IPC分类号： H04W72/04 ,  H04W52/04

    CPC分类号： H04W52/04 ,  H04W52/143 ,  H04W52/283

    摘要： The present invention discloses a method and an apparatus for notification of emitted energy. The method includes: performing an emitted energy decrease on resource elements in a current cell that have a same time-frequency location as part or all of resource elements where a reference signal of a neighboring cell is located; obtaining an emitted energy parameter of an energy non-decreased resource element (NRE) in the current cell according to a decreased amount of emitted energy of an emitted energy decreased resource element (DRE); and notifying the emitted energy parameter of the NRE to a user equipment (UE). According to embodiments of the present invention, the waste of emitted energy may be avoided, the emitted energy of part of REs is increased, and further, the signal to interference plus noise ratio (SINR) and throughput of service data may be increased.

    摘要翻译： 本发明公开了一种通知发射能量的方法和装置。 该方法包括：对当前小区中的资源元素执行发射的能量减少，其具有与相邻小区的参考信号所在的资源元素的部分或全部相同的时间 - 频率位置; 根据发射能量减少的资源元素（DRE）的发射能量的减少量，获得当前小区中能量非减少资源元素（NRE）的发射能量参数; 并向用户设备（UE）通知NRE发射的能量参数。 根据本发明的实施例，可以避免发射能量的浪费，部分RE的发射能量增加，此外，信号干扰加噪声比（SINR）和服务数据吞吐量可能会增加。

    Method and Apparatus for Performing Channel Measurement for Cell
    8.
    发明申请
    Method and Apparatus for Performing Channel Measurement for Cell 有权
    用于执行信元通道测量的方法和装置

    公开(公告)号：US20120190356A1

    公开(公告)日：2012-07-26

    申请号：US13434561

    申请日：2012-03-29

    申请人： Yajun Zhao ,  Qing Li ,  Xiaoan Fan ,  Lei Wan

    发明人： Yajun Zhao ,  Qing Li ,  Xiaoan Fan ,  Lei Wan

    IPC分类号： H04W24/10

    CPC分类号： H04W24/10 ,  H04L5/0007 ,  H04L5/0035 ,  H04L5/0048 ,  H04L5/0057 ,  H04L5/0094 ,  H04L25/0204 ,  H04L25/0226

    摘要： Embodiments of the present invention provide a method and an apparatus for performing channel measurement for a cell. The method includes: sending information about a location of a to-be-measured reference signal to a user equipment, where the location of the to-be-measured reference signal is a part of a location occupied by a reference signal of the cell; and receiving a channel measurement report of the cell. The channel measurement report is sent by the user equipment and is obtained after the user equipment performs channel measurement for the cell according to the information about the location of the to-be-measured reference signal.

    摘要翻译： 本发明的实施例提供了一种用于对小区执行信道测量的方法和装置。 该方法包括：向用户设备发送关于被测量参考信号的位置的信息，其中待测量的参考信号的位置是由小区的参考信号占据的位置的一部分; 以及接收小区的信道测量报告。 信道测量报告由用户设备发送，并且在用户设备根据关于被测量参考信号的位置的信息对小区进行信道测量之后获得。

    METHOD, NETWORK DEVICE AND SYSTEM FOR DETERMINING RESOURCE MAPPING IN COORDINATED MULTI-POINT TRANSMISSION
    9.
    发明申请
    METHOD, NETWORK DEVICE AND SYSTEM FOR DETERMINING RESOURCE MAPPING IN COORDINATED MULTI-POINT TRANSMISSION 有权
    方法，网络设备和用于确定协调多点传输资源映射的系统

    公开(公告)号：US20110235603A1

    公开(公告)日：2011-09-29

    申请号：US13112736

    申请日：2011-05-20

    申请人： Xingqing Cheng ,  Lei Wan ,  Mingyu Zhou ,  Yajun Zhao ,  Xiaotao Ren

    发明人： Xingqing Cheng ,  Lei Wan ,  Mingyu Zhou ,  Yajun Zhao ,  Xiaotao Ren

    IPC分类号： H04W72/04

    CPC分类号： H04L5/0053 ,  H04L5/0032 ,  H04L5/0035

    摘要： A method, a network device, and a system for determining resource mapping in CoMP transmission are disclosed. The method includes: the cooperative cells that perform CoMP transmission for a UE negotiate a mapping rule used by the cooperative cells when the status of the CoMP transmission of the UE changes, where the mapping rule includes the number of and position of OFDM symbols allocated to a PDCCH domain and/or a data channel domain; and the negotiated mapping rule is notified to the UE. In this embodiment, before the downlink signals are transmitted, the mapping rule used by each cooperative cell for CoMP transmission is negotiated between the cooperative cells, and therefore, the UE can accurately receive the signal sent by multiple cooperative cells and the performance of CoMP transmission in the system is improved.

    摘要翻译： 公开了一种在CoMP传输中确定资源映射的方法，网络设备和系统。 该方法包括：当UE的CoMP传输的状态改变时，执行CoMP传输的协作小区协调协作小区使用的映射规则，其中映射规则包括分配给 PDCCH域和/或数据信道域; 并且协商的映射规则被通知给UE。 在本实施例中，在发送下行链路信号之前，协作小区之间协商由协作小区进行CoMP传输所使用的映射规则，因此UE可以准确地接收由多个协作小区发送的信号和执行CoMP传输 在系统上有所改善。

    Process for the preparation of atorvastatin and intermediates
    10.
    发明授权
    Process for the preparation of atorvastatin and intermediates 失效
    制备阿托伐他汀和中间体的方法

    公开(公告)号：US07812179B2

    公开(公告)日：2010-10-12

    申请号：US12222690

    申请日：2008-08-14

    申请人： Fan Wang ,  Daqing Che ,  Bhaskar Reddy Guntoori ,  Yajun Zhao ,  Aaron C. Kinsman ,  Jody Faught ,  Alan Chow

    发明人： Fan Wang ,  Daqing Che ,  Bhaskar Reddy Guntoori ,  Yajun Zhao ,  Aaron C. Kinsman ,  Jody Faught ,  Alan Chow

    IPC分类号： C07D207/333

    CPC分类号： C07D207/34

    摘要： A process is provided for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 comprising: (a) reacting the aldehyde 1 with the enolate form of (S)-2-hydroxy-1,2,2-triphenylethyl acetate substituent in a chelating co-solvent; (b) hydrolysis of (R,S)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (S)-2-hydroxy-1,2,2-triphenylethyl ester (2a and 2b) using a base, preferably an alkali metal base, preferably in a solvent to form the carboxylic acid 7; (c) treating the acid 7 with a chiral base to form a salt and purifying the salt to obtain enantiomerically enriched (R)-7 chiral base salt; (d) alkylation of the (R)-7 chiral base salt or the free base derived from (R)-7, forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 and atorvastatin calcium 6, wherein R is a C1 to C6 alkyl, C6 to C9 aryl or C7 to C10 aralkyl.

    摘要翻译： 提供了制备（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -5-羟基-3-氧代-1-庚酸，R-取代的酯9，其包含：（a）使醛1与烯醇化形式的（S）-2-羟基-1,2,2-三苯基乙基乙酸酯取代基 在螯合助溶剂中; （b）（R，S）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基 ] -3-羟基-1-戊酸，（S）-2-羟基-1,2,2-三苯基乙酯（2a和2b），使用碱，优选碱金属碱，优选在溶剂中形成羧酸 酸7; （c）用手性碱处理酸7以形成盐并纯化该盐以获得对映体富集的（R）-7手性碱盐; （d）（R）-7手性碱盐或衍生自（R）-7的游离碱的烷基化，形成（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基） 3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -5-羟基-3-氧代-1-庚酸，R-取代的酯9和阿托伐他汀钙6，其中R是C1 C6烷基，C6〜C9芳基或C7〜C10芳烷基。