公开(公告)号：US09382272B2

公开(公告)日：2016-07-05

申请号：US13145999

申请日：2010-01-22

申请人： Kiran Kumar Kothakonda ,  Fan Wang ,  Bhaskar Reddy Guntoori ,  Minh T. N. Nguyen ,  Alfredo Paul Ceccarelli ,  Yajun Zhao ,  Uma Kotipalli ,  Sammy Chris Duncan ,  Kaarina K. Milnes ,  Kevin Wade Kells ,  Laura Kaye Montemayor

发明人： Kiran Kumar Kothakonda ,  Fan Wang ,  Bhaskar Reddy Guntoori ,  Minh T. N. Nguyen ,  Alfredo Paul Ceccarelli ,  Yajun Zhao ,  Uma Kotipalli ,  Sammy Chris Duncan ,  Kaarina K. Milnes ,  Kevin Wade Kells ,  Laura Kaye Montemayor

IPC分类号： C07D323/04 ,  C07D311/00 ,  C07D315/00 ,  C07D307/93 ,  C07C61/06 ,  C07C69/74 ,  C07F7/18 ,  C07C69/734 ,  C07C69/738 ,  C07C405/00 ,  C07D307/935

CPC分类号： C07F7/1892 ,  C07C69/734 ,  C07C69/738 ,  C07C405/00 ,  C07C2601/08 ,  C07D307/935

摘要： There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds. (I)

摘要翻译： 提供了用于制备卢比克石及其中间体的方法。 还提供了化合物，包括用于制备柳替罗石的中间体以及包含卢比石和其它化合物的组合物，包括用于制备柳普罗石和其它化合物的中间体。 （一世）

公开(公告)号：US08842616B2

公开(公告)日：2014-09-23

申请号：US13112736

申请日：2011-05-20

申请人： Xingqing Cheng ,  Lei Wan ,  Mingyu Zhou ,  Yajun Zhao ,  Xiaotao Ren

发明人： Xingqing Cheng ,  Lei Wan ,  Mingyu Zhou ,  Yajun Zhao ,  Xiaotao Ren

IPC分类号： H04W4/00 ,  H04L5/00

CPC分类号： H04L5/0053 ,  H04L5/0032 ,  H04L5/0035

摘要： A method, a network device, and a system for determining resource mapping in CoMP transmission are disclosed. The method includes: the cooperative cells that perform CoMP transmission for a UE negotiate a mapping rule used by the cooperative cells when the status of the CoMP transmission of the UE changes, where the mapping rule includes the number of and position of OFDM symbols allocated to a PDCCH domain and/or a data channel domain; and the negotiated mapping rule is notified to the UE. In this embodiment, before the downlink signals are transmitted, the mapping rule used by each cooperative cell for CoMP transmission is negotiated between the cooperative cells, and therefore, the UE can accurately receive the signal sent by multiple cooperative cells and the performance of CoMP transmission in the system is improved.

摘要翻译： 公开了一种在CoMP传输中确定资源映射的方法，网络设备和系统。 该方法包括：当UE的CoMP传输的状态改变时，执行CoMP传输的协作小区协调协作小区使用的映射规则，其中映射规则包括分配给 PDCCH域和/或数据信道域; 并且协商的映射规则被通知给UE。 在本实施例中，在发送下行链路信号之前，协作小区之间协商由协作小区进行CoMP传输所使用的映射规则，因此UE可以准确地接收由多个协作小区发送的信号和执行CoMP传输 在系统上有所改善。

公开(公告)号：US07834195B2

公开(公告)日：2010-11-16

申请号：US11808942

申请日：2007-06-14

申请人： K. S. Keshava Murthy ,  Yajun Zhao ,  Allan W. Rey ,  Daqing Che ,  David A. Stradiotto ,  Uma Kotipalli

发明人： K. S. Keshava Murthy ,  Yajun Zhao ,  Allan W. Rey ,  Daqing Che ,  David A. Stradiotto ,  Uma Kotipalli

IPC分类号： C07D207/00

CPC分类号： C07D207/34

摘要： Atorvastatin calcium propylene glycol solvates and processes to prepare these novel solvates which are particularly useful and suitable for pharmaceutical applications.

摘要翻译： 阿托伐他汀钙丙二醇溶剂化物并制备这些新的溶剂化物，这些新的溶剂合物特别有用并适用于药物应用。

公开(公告)号：US07429613B2

公开(公告)日：2008-09-30

申请号：US11487500

申请日：2006-07-17

申请人： Fan Wang ,  Daqing Che ,  Bhaskar Reddy Guntoori ,  Yajun Zhao ,  Aaron C. Kinsman ,  Jody Faught ,  Alan Chow

发明人： Fan Wang ,  Daqing Che ,  Bhaskar Reddy Guntoori ,  Yajun Zhao ,  Aaron C. Kinsman ,  Jody Faught ,  Alan Chow

IPC分类号： A61K31/4025 ,  C07D207/327

CPC分类号： C07D207/34

摘要： A process is provided for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 comprising: (a) reacting the aldehyde 1 with the enolate form of (S)-2-hydroxy-1,2,2-triphenylethyl acetate substituent in a chelating co-solvent; (b) hydrolysis of (R,S)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (S)-2-hydroxy-1,2,2-triphenylethyl ester (2a and 2b) using a base, preferably an alkali metal base, preferably in a solvent to form the carboxylic acid 7; (c) treating the acid 7 with a chiral base to form a salt and purifying the salt to obtain enantiomerically enriched (R)-7 chiral base salt; (d) alkylation of the (R)-7 chiral base salt or the free base derived from (R)-7, forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 and atorvastatin calcium 6, wherein R is a C1 to C6 alkyl, C6 to C9 aryl or C7 to C10 aralkyl.

摘要翻译： 提供了制备（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -5-羟基-3-氧代-1-庚酸，R-取代的酯9，其包含：（a）使醛1与烯醇化形式的（S）-2-羟基-1,2,2-三苯基乙基乙酸酯取代基 在螯合助溶剂中; （b）（R，S）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基 ] -3-羟基-1-戊酸，（S）-2-羟基-1,2,2-三苯基乙酯（2a和2b），使用碱，优选碱金属碱，优选在溶剂中形成羧酸 酸7; （c）用手性碱处理酸7以形成盐并纯化该盐以获得对映体富集的（R）-7手性碱盐; （d）（R）-7手性碱盐或衍生自（R）-7的游离碱的烷基化，形成（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基） 3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -5-羟基-3-氧代-1-庚酸，R-取代的酯9和阿托伐他汀钙6，其中R是C1 C6烷基，C6〜C9芳基或C7〜C10芳烷基。

公开(公告)号：US07193090B2

公开(公告)日：2007-03-20

申请号：US10800741

申请日：2004-03-16

申请人： Bhaskar Reddy Guntoori ,  Daqing Che ,  Fan Wang ,  Yajun Zhao ,  K. S. Keshava Murthy ,  Stephen E. Horne

发明人： Bhaskar Reddy Guntoori ,  Daqing Che ,  Fan Wang ,  Yajun Zhao ,  K. S. Keshava Murthy ,  Stephen E. Horne

IPC分类号： C07D207/00

CPC分类号： C07D207/416 ,  C07D207/34

摘要： A process for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester comprising: (a) reduction of 5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-oxo-1-pentanoic acid, (R)-2-hydroxy-1,2,2-triphenylethyl ester; (b) hydrolysis of (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (R)-2-hydroxy-1,2,2-triphenylethyl ester using an alkali base in a solvent to form the acid; (c) alkylation of the acid forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, tert-butylester.

摘要翻译： 制备（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -5 - 羟基-3-氧代-1-庚酸叔丁酯包括：（a）还原5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基 ）羰基] -1H-吡咯-1-基] -3-氧代-1-戊酸，（R）-2-羟基-1,2,2-三苯乙基酯; （b）（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] 3-羟基-1-戊酸，（R）-2-羟基-1,2,2-三苯基乙基酯，使用碱在溶剂中形成酸; （c）酸形成（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基 吡啶-3-基] -5-羟基-3-氧代-1-庚酸叔丁酯。

公开(公告)号：US20060252816A1

公开(公告)日：2006-11-09

申请号：US11487500

申请日：2006-07-17

申请人： Fan Wang ,  Daqing Che ,  Bhaskar Guntoori ,  Yajun Zhao ,  Aaron Kinsman ,  Jody Faught ,  Alan Chow

发明人： Fan Wang ,  Daqing Che ,  Bhaskar Guntoori ,  Yajun Zhao ,  Aaron Kinsman ,  Jody Faught ,  Alan Chow

IPC分类号： A61K31/401

CPC分类号： C07D207/34

摘要： A process is provided for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 comprising: (a) reacting the aldehyde 1 with the enolate form of (S)-2-hydroxy-1,2,2-triphenylethyl acetate substituent in a chelating co-solvent; (b) hydrolysis of (R,S)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-1-pentanoic acid, (S)-2-hydroxy-1,2,2-triphenylethyl ester (2a and 2b) using a base, preferably an alkali metal base, preferably in a solvent to form the carboxylic acid 7; (c) treating the acid 7 with a chiral base to form a salt and purifying the salt to obtain enantiomerically enriched (R)-7 chiral base salt; (d) alkylation of the (R)-7 chiral base salt or the free base derived from (R)-7, forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-1-heptanoic acid, R-substituted ester 9 and atorvastatin calcium 6, wherein R is a C1 to C6 alkyl, C6 to C9 aryl or C7 to C10 aralkyl.

公开(公告)号：US08879484B2

公开(公告)日：2014-11-04

申请号：US13340337

申请日：2011-12-29

申请人： Lei Wan ,  Qiang Li ,  Yajun Zhao ,  Xingqing Cheng

发明人： Lei Wan ,  Qiang Li ,  Yajun Zhao ,  Xingqing Cheng

IPC分类号： H04W4/00 ,  H04J11/00 ,  H04L5/00 ,  H04B7/02

CPC分类号： H04L5/0048 ,  H04B7/024 ,  H04J11/0056 ,  H04L5/0035

摘要： Embodiments of the present invention disclose a method, an apparatus, and a system for processing a reference signal. The present invention relates to the field of radio communications technologies, and solves a technical problem that it is impossible to meet a requirement for measurement of downlink channels of multiple cells in a coordinated multipoint transmission/reception (CoMP) scenario in the prior art. According to the embodiments of the present invention, a reference signal is sent in a specified pilot position to a target user equipment (UE) where data puncturing is performed, in positions corresponding to the specified pilot position, with respect to data symbols simultaneously sent by an evolved NodeB (eNB) to which another cell in a CoMP set of the UE belongs, and the specified pilot position is orthogonally separated from a reference signal pilot position of the another cell in the CoMP set.

摘要翻译： 本发明的实施例公开了一种用于处理参考信号的方法，装置和系统。 本发明涉及无线电通信技术领域，并且解决了现有技术中协调多点发送/接收（CoMP）场景中不可能满足测量多个小区的下行链路信道的要求的技术问题。 根据本发明的实施例，在与指定的导频位置对应的位置中，相对于同时发送的数据符号，将指定导频位置的参考信号发送到执行数据删截的目标用户设备（UE） UE的CoMP集合中的另一小区所属的演进节点B（eNB），并且指定的导频位置与CoMP集合中的另一小区的参考信号导频位置正交地分离。

公开(公告)号：US08761067B2

公开(公告)日：2014-06-24

申请号：US13469512

申请日：2012-05-11

申请人： Xiaotao Ren ,  Lei Wan ,  Zhiyu Yan ,  Yajun Zhao ,  Xiaoan Fan

发明人： Xiaotao Ren ,  Lei Wan ,  Zhiyu Yan ,  Yajun Zhao ,  Xiaoan Fan

IPC分类号： G08C17/00

CPC分类号： H04W52/04 ,  H04W52/143 ,  H04W52/283

摘要： The present invention discloses a method and an apparatus for notification of emitted energy. The method includes: performing an emitted energy decrease on resource elements in a current cell that have a same time-frequency location as part or all of resource elements where a reference signal of a neighboring cell is located; obtaining an emitted energy parameter of an energy non-decreased resource element (NRE) in the current cell according to a decreased amount of emitted energy of an emitted energy decreased resource element (DRE); and notifying the emitted energy parameter of the NRE to a user equipment (UE). According to embodiments of the present invention, the waste of emitted energy may be avoided, the emitted energy of part of REs is increased, and further, the signal to interference plus noise ratio (SINR) and throughput of service data may be increased.

摘要翻译： 本发明公开了一种通知发射能量的方法和装置。 该方法包括：对当前小区中的资源元素执行发射的能量减少，其具有与相邻小区的参考信号所在的资源元素的部分或全部相同的时间 - 频率位置; 根据发射能量减少的资源元素（DRE）的发射能量的减少量，获得当前小区中能量非减少资源元素（NRE）的发射能量参数; 并向用户设备（UE）通知NRE发射的能量参数。 根据本发明的实施例，可以避免发射能量的浪费，部分RE的发射能量增加，此外，信号干扰加噪声比（SINR）和服务数据吞吐量可能会增加。

公开(公告)号：US08588762B2

公开(公告)日：2013-11-19

申请号：US13434561

申请日：2012-03-29

申请人： Yajun Zhao ,  Qiang Li ,  Xiaoan Fan ,  Lei Wan

发明人： Yajun Zhao ,  Qiang Li ,  Xiaoan Fan ,  Lei Wan

IPC分类号： H04W4/00

CPC分类号： H04W24/10 ,  H04L5/0007 ,  H04L5/0035 ,  H04L5/0048 ,  H04L5/0057 ,  H04L5/0094 ,  H04L25/0204 ,  H04L25/0226

摘要： Embodiments of the present invention provide a method and an apparatus for performing channel measurement for a cell. The method includes: sending information about a location of a to-be-measured reference signal to a user equipment, where the location of the to-be-measured reference signal is a part of a location occupied by a reference signal of the cell; and receiving a channel measurement report of the cell. The channel measurement report is sent by the user equipment and is obtained after the user equipment performs channel measurement for the cell according to the information about the location of the to-be-measured reference signal.

摘要翻译： 本发明的实施例提供了一种用于对小区执行信道测量的方法和装置。 该方法包括：向用户设备发送关于被测量参考信号的位置的信息，其中待测量的参考信号的位置是由小区的参考信号占据的位置的一部分; 以及接收小区的信道测量报告。 信道测量报告由用户设备发送，并且在用户设备根据关于被测量参考信号的位置的信息对小区进行信道测量之后获得。

公开(公告)号：US08260211B2

公开(公告)日：2012-09-04

申请号：US13106054

申请日：2011-05-12

申请人： Lei Wan ,  Xingqing Cheng ,  Mingyu Zhou ,  Yajun Zhao

发明人： Lei Wan ,  Xingqing Cheng ,  Mingyu Zhou ,  Yajun Zhao

IPC分类号： H04Q7/20

CPC分类号： H04W72/044 ,  H04J11/0023 ,  H04L5/0007 ,  H04L5/0035 ,  H04L5/0048 ,  H04L25/0204 ,  H04L25/0224 ,  H04W72/0433

摘要： A method, an apparatus and a system for estimating channels are disclosed. A method for estimating channels includes: receiving downlink signals inclusive of reference signals from two or more Access Points (APs), where the relative frequency shift between reference signals sent by different APs is zero; and performing channel estimation according to the reference signals. Another method for estimating channels includes: receiving downlink signals inclusive of reference signals from two or more APs, where for a first AP and a second AP among the two or more APs, a specific time-frequency lattice in the downlink signals sent by the first AP includes no data signal, and the specific time-frequency lattice corresponds to a time-frequency lattice utilized by the second AP to send a reference signal; and performing channel estimation according to the reference signals. The technical solution disclosed herein eliminates the interference between the reference signal and the data signal, enables the UE to estimate the channel value between the UE and the cooperative APs accurately, and improves the UE performance.

摘要翻译： 公开了一种用于估计信道的方法，装置和系统。 用于估计信道的方法包括：从两个或多个接入点（AP）接收包括参考信号的下行链路信号，其中由不同AP发送的参考信号之间的相对频移为零; 并根据参考信号进行信道估计。 用于估计信道的另一方法包括：从两个或多个AP接收包括参考信号的下行链路信号，其中对于两个或更多个AP中的第一AP和第二AP，下行链路信号中的特定时间 - 频率格点由第一 AP不包括数据信号，并且特定时间频率格对应于由第二AP利用来发送参考信号的时间 - 频率格点; 并根据参考信号进行信道估计。 本文公开的技术方案消除了参考信号与数据信号之间的干扰，使UE能够准确地估计UE与协作AP之间的信道值，提高UE的性能。