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1.发明申请HIGHLY SOLUBLE PYRIMIDO-DIONE-QUINOLINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER 有权高可溶性吡啶二酮 - 喹啉化合物及其在治疗癌症中的应用公开(公告)号：US20100056549A1
公开(公告)日：2010-03-04
申请号：US12304980
申请日：2007-06-13
申请人： Allan Weissman , Yili Yang
发明人： Allan Weissman , Yili Yang
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70
摘要： The present invention features pyrimido-dione-quinoline compounds having improved solubility, pharmaceutical compositions of substituted pyrimido-dione-quinoline compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more pyrimido-dione-quinoline compounds of the invention.
摘要翻译： 本发明具有改进的溶解度的嘧啶二酮 - 喹啉化合物，取代的嘧啶二酮 - 喹啉化合物的药物组合物和治疗癌症患者的方法，所述方法包括向患者施用一种或多种嘧啶二酮 - 喹啉化合物 的本发明。
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公开(公告)号：US20060211718A1
公开(公告)日：2006-09-21
申请号：US10545547
申请日：2004-02-12
申请人： Allan Weissman , Karen Vousden , Jane Jensen , Yili Yang , Shengyun Fang , Douglas Woods , John Kenten , Ilia Davydov , Yassamin Safiran , Pankaj Oberoi
发明人： Allan Weissman , Karen Vousden , Jane Jensen , Yili Yang , Shengyun Fang , Douglas Woods , John Kenten , Ilia Davydov , Yassamin Safiran , Pankaj Oberoi
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention.
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3.发明申请Ube2g2 Binding Domain in The Ubiquitin Ligase Gp78 And Methods Of Use Thereof 有权Ube2g2结合域在泛素连接酶Gp78及其使用方法公开(公告)号：US20080090249A1
公开(公告)日：2008-04-17
申请号：US11597453
申请日：2005-04-27
申请人： Allan Weissman , Jennifer Mariano , Bo Chen , Yien Tsai
发明人： Allan Weissman , Jennifer Mariano , Bo Chen , Yien Tsai
CPC分类号： C12N9/93
摘要： The present invention features isolated nucleic acid molecules, designated G2BD nucleic acid molecules, which encode the binding site from the gp78 ubiquitin ligase that binds to the Ube2G2 ubiquitin conjugating enzyme. The invention further provides isolated G2BD proteins and fusion proteins. Still further provided are diagnostic and therapeutic methods, as well as screening assays utilizing compositions of the invention.
摘要翻译： 本发明的特征在于分离的核酸分子，命名为G2BD核酸分子，其编码结合于Ube2G2泛素缀合酶的gp78泛素连接酶的结合位点。 本发明还提供了分离的G2BD蛋白和融合蛋白。 还提供了诊断和治疗方法，以及利用本发明组合物的筛选测定。
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4.发明授权Ube2G2 binding domain in the ubiquitin ligase gp78 and methods of use thereof 有权Uub2g2结合域在泛素连接酶gp78及其使用方法公开(公告)号：US08420776B2
公开(公告)日：2013-04-16
申请号：US11597453
申请日：2005-04-27
申请人： Allan Weissman , Jennifer Mariano , Bo Chen , Yien Che Tsai
发明人： Allan Weissman , Jennifer Mariano , Bo Chen , Yien Che Tsai
IPC分类号： C07K14/435 , C12P21/02
CPC分类号： C12N9/93
摘要： The present invention features isolated nucleic acid molecules, designated G2BD nucleic acid molecules, which encode the binding site from the gp78 ubiquitin ligase that binds to the Ube2G2 ubiquitin conjugating enzyme. The invention further provides isolated G2BD proteins and fusion proteins. Still further provided are diagnostic and therapeutic methods, as well as screening assays utilizing compositions of the invention.
摘要翻译： 本发明的特征在于分离的核酸分子，命名为G2BD核酸分子，其编码结合于Ube2G2泛素缀合酶的gp78泛素连接酶的结合位点。 本发明还提供了分离的G2BD蛋白和融合蛋白。 还提供了诊断和治疗方法，以及利用本发明组合物的筛选测定。
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