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    4-aminoquinazoline EGFR Inhibitors
    7.
    发明授权
    4-aminoquinazoline EGFR Inhibitors 失效
    4-氨基喹唑啉EGFR抑制剂

    公开(公告)号：US5760041A

    公开(公告)日：1998-06-02

    申请号：US785910

    申请日：1997-01-21

    申请人： Allan Wissner ,  Bernard D. Johnson ,  Middleton B. Floyd, Jr. ,  Douglas B. Kitchen

    发明人： Allan Wissner ,  Bernard D. Johnson ,  Middleton B. Floyd, Jr. ,  Douglas B. Kitchen

    IPC分类号： A61K31/505 ,  A61K31/517 ,  A61P35/00 ,  A61P43/00 ,  C07D239/94

    CPC分类号： C07D239/94

    摘要： This invention provides a compound having the formula ##STR1## wherein: X is phenyl which is optionally substituted; R and R.sub.1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl; R.sub.2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl; Y is a radical selected from the group consisting of ##STR2## R.sub.3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n=2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R.sub.3 of Y may be the same or different which are useful as antineoplastic agents.

    摘要翻译： 本发明提供了具有下式的化合物：其中：X是任选取代的苯基; R和R 1各自独立地为氢，卤素，烷基，烷氧基，羟基或三氟甲基; R2是氢，烷基，烷氧基，羟基，三氟甲基; Y是选自由下列组成的组的基团：R 3独立地是氢，烷基，羧基，烷氧羰基，苯基或烷基烷基; n = 2-4; 或其药学上可接受的盐，条件是Y的每个R 3可以相同或不同，其可用作抗肿瘤剂。

    1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
    10.
    发明授权
    1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives 失效
    1-羟甲基-11-脱氧-15-羟基 - 前列腺-1-醇衍生物

    公开(公告)号：US4288629A

    公开(公告)日：1981-09-08

    申请号：US137042

    申请日：1980-04-03

    申请人： Allan Wissner ,  Middleton B. Floyd, Jr.

    发明人： Allan Wissner ,  Middleton B. Floyd, Jr.

    IPC分类号： C07C405/00 ,  C07D317/16 ,  C07D317/34 ,  C07C35/06 ,  C07C49/597 ,  C07C49/798

    CPC分类号： C07C405/0025 ,  C07C405/0016 ,  C07D317/16 ,  C07D317/34

    摘要： Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation inhibitors and bronchodilators.

    摘要翻译： 公开前列腺素类似物，其具有以基团-CH（OR'）OR“终止的α-链，其中R'和R”相同或不同，并且是氢，C 1至C 4烷酰基或任选取代的苯甲酰基，取代基 选自C1至C4烷基，C1至C4烷氧基，卤素和三氟甲基。 这些化合物可用作降压药，胃分泌和血小板聚集抑制剂和支气管扩张剂。